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Book Chapter: Extracellular matrix and its role in spermatogenesis

TitleExtracellular matrix and its role in spermatogenesis
Authors
Issue Date2008
PublisherSpringer Science+Business Media, Landes Bioscience
Citation
Extracellular matrix and its role in spermatogenesis. In Cheng, CY (Ed.), Molecular Mechanisms in Spermatogenesis, p. 74-91. New York: Springer Science+Business Media ; Austin, Tex.: Landes Bioscience, 2008 How to Cite?
AbstractIn adult mammalian testes, such as rats, Sertoli and germ cells at different stages of their development in the seminiferous epithelium are in close contact with the basement membrane, a modified form of extracellular matrix (ECM). In essence, Sertoli and germ cells in particular spermatogonia are “resting” on the basement membrane at different stages of the seminiferous epithelial cycle, relying on its structural and hormonal supports. Thus, it is not entirely unexpected that ECM plays a significant role in regulating spermatogenesis, particularly spermatogonia and Sertoli cells, and the blood-testis barrier (BTB) constituted by Sertoli cells since these cells are in physical contact with the basement membrane. Additionally, the basement membrane is also in close contact with the underlying collagen network and the myoid cell layers, which together with the lymphatic network, constitute the tunica propria. The seminiferous epithelium and the tunica propria, in turn, constitute the seminiferous tubule, which is the functional unit that produces spermatozoa via its interaction with Leydig cells in the interstitium. In short, the basement membrane and the underlying collagen network that create the acellular zone of the tunica propria may even facilitate cross-talk between the seminiferous epithelium, the myoid cells and cells in the interstitium. Recent studies in the field have illustrated the crucial role of ECM in supporting Sertoli and germ cell function in the seminiferous epithelium, including the BTB dynamics. In this chapter, we summarize some of the latest findings in the field regarding the functional role of ECM in spermatogenesis using the adult rat testis as a model. We also high light specific areas of research that deserve attention for investigators in the field.
Persistent Identifierhttp://hdl.handle.net/10722/190882
ISBN
Series/Report no.Advances in experimental medicine and biology; v. 636

 

DC FieldValueLanguage
dc.contributor.authorSiu, KYen_US
dc.contributor.authorCheng, CYen_US
dc.date.accessioned2013-09-17T15:53:24Z-
dc.date.available2013-09-17T15:53:24Z-
dc.date.issued2008en_US
dc.identifier.citationExtracellular matrix and its role in spermatogenesis. In Cheng, CY (Ed.), Molecular Mechanisms in Spermatogenesis, p. 74-91. New York: Springer Science+Business Media ; Austin, Tex.: Landes Bioscience, 2008en_US
dc.identifier.isbn9780387799902-
dc.identifier.urihttp://hdl.handle.net/10722/190882-
dc.description.abstractIn adult mammalian testes, such as rats, Sertoli and germ cells at different stages of their development in the seminiferous epithelium are in close contact with the basement membrane, a modified form of extracellular matrix (ECM). In essence, Sertoli and germ cells in particular spermatogonia are “resting” on the basement membrane at different stages of the seminiferous epithelial cycle, relying on its structural and hormonal supports. Thus, it is not entirely unexpected that ECM plays a significant role in regulating spermatogenesis, particularly spermatogonia and Sertoli cells, and the blood-testis barrier (BTB) constituted by Sertoli cells since these cells are in physical contact with the basement membrane. Additionally, the basement membrane is also in close contact with the underlying collagen network and the myoid cell layers, which together with the lymphatic network, constitute the tunica propria. The seminiferous epithelium and the tunica propria, in turn, constitute the seminiferous tubule, which is the functional unit that produces spermatozoa via its interaction with Leydig cells in the interstitium. In short, the basement membrane and the underlying collagen network that create the acellular zone of the tunica propria may even facilitate cross-talk between the seminiferous epithelium, the myoid cells and cells in the interstitium. Recent studies in the field have illustrated the crucial role of ECM in supporting Sertoli and germ cell function in the seminiferous epithelium, including the BTB dynamics. In this chapter, we summarize some of the latest findings in the field regarding the functional role of ECM in spermatogenesis using the adult rat testis as a model. We also high light specific areas of research that deserve attention for investigators in the field.-
dc.languageengen_US
dc.publisherSpringer Science+Business Media, Landes Bioscience-
dc.relation.ispartofMolecular Mechanisms in Spermatogenesis-
dc.relation.ispartofseriesAdvances in experimental medicine and biology; v. 636-
dc.titleExtracellular matrix and its role in spermatogenesisen_US
dc.typeBook_Chapteren_US
dc.identifier.emailSiu, KY: mkysiu@hkucc.hku.hken_US
dc.identifier.authoritySiu, KY=rp00275en_US
dc.identifier.doi10.1007/978-0-387-09597-4_5-
dc.identifier.hkuros222300en_US
dc.identifier.hkuros132888-
dc.identifier.spage74-
dc.identifier.epage91-
dc.publisher.placeNew York, Austin, Tex.-

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