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Conference Paper: Propofol post-conditioning confers ischemic cardioprotection via HO-1/STAT3 signaling: role of peroxynitrite

TitlePropofol post-conditioning confers ischemic cardioprotection via HO-1/STAT3 signaling: role of peroxynitrite
Authors
KeywordsBiology
Issue Date2013
PublisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/
Citation
The 2013 Annual Meeting of Experimental Biology (EB 2013), Boston, MA., 28 March-1 April 2013. In The FASEB Journal, 2013, v. 27 meeting abstracts, no. lb619 How to Cite?
AbstractPropofol, an aesthetic with antioxidant and peroxynitrite (ONOO–) scavenging property, when given during reperfusion attenuates myocardial ischemia/reperfusion (MI/R) injury. Heme oxygenase-1 (HO-1) and STAT3 are key proteins in postconditioning (PC) cardioprotection. We explored if Propofol PC (PPC) confers cardioprotection by scavenging ONOO– and activating the HO-1/STAT3 pathway. Rats were subjected to 30 min coronary artery occlusion and 120 min reperfusion in vivo. Rats (n=7/group) were respectively treated with Propofol (2mg/kg), IPC, ONOO– generator SIN-1(1.5 mg/kg), ONOO– scavenger FeTPPS (10 mg/kg) during MI/R. Also, primarily cultured cardiomyocytes were subjected to hypoxia/re-oxygenation in the absence or presence of SIN-1 or FeTPPS. PPC conferred similar cardioprotection to IPC in reducing postischemic myocardial infarction compared to control. FeTPPS enhanced PPC cardioprotection while SIN-1 abolished PPC cardioprotection. HO-1 and p-STAT3 protein expression was increased in PPC group compared to control and it was associated with decreased ONOO– production and increased antioxidant capacity. PPC also attenuated post-hypoxic lactate dehydrogenase in vitro. However, HO-1/STAT3 gene knockdown abolished protective effect of PPC. In conclusion, PPC confers cardioprotection by scavenging ONOO– and activating the HO-1/STAT3 pathway.
Persistent Identifierhttp://hdl.handle.net/10722/190357
ISSN
2015 Impact Factor: 5.299
2015 SCImago Journal Rankings: 2.775

 

DC FieldValueLanguage
dc.contributor.authorMao, Xen_US
dc.contributor.authorLi, Hen_US
dc.contributor.authorIrwin, Men_US
dc.contributor.authorWong, Gen_US
dc.contributor.authorXia, Zen_US
dc.date.accessioned2013-09-17T15:20:19Z-
dc.date.available2013-09-17T15:20:19Z-
dc.date.issued2013en_US
dc.identifier.citationThe 2013 Annual Meeting of Experimental Biology (EB 2013), Boston, MA., 28 March-1 April 2013. In The FASEB Journal, 2013, v. 27 meeting abstracts, no. lb619en_US
dc.identifier.issn0892-6638-
dc.identifier.urihttp://hdl.handle.net/10722/190357-
dc.description.abstractPropofol, an aesthetic with antioxidant and peroxynitrite (ONOO–) scavenging property, when given during reperfusion attenuates myocardial ischemia/reperfusion (MI/R) injury. Heme oxygenase-1 (HO-1) and STAT3 are key proteins in postconditioning (PC) cardioprotection. We explored if Propofol PC (PPC) confers cardioprotection by scavenging ONOO– and activating the HO-1/STAT3 pathway. Rats were subjected to 30 min coronary artery occlusion and 120 min reperfusion in vivo. Rats (n=7/group) were respectively treated with Propofol (2mg/kg), IPC, ONOO– generator SIN-1(1.5 mg/kg), ONOO– scavenger FeTPPS (10 mg/kg) during MI/R. Also, primarily cultured cardiomyocytes were subjected to hypoxia/re-oxygenation in the absence or presence of SIN-1 or FeTPPS. PPC conferred similar cardioprotection to IPC in reducing postischemic myocardial infarction compared to control. FeTPPS enhanced PPC cardioprotection while SIN-1 abolished PPC cardioprotection. HO-1 and p-STAT3 protein expression was increased in PPC group compared to control and it was associated with decreased ONOO– production and increased antioxidant capacity. PPC also attenuated post-hypoxic lactate dehydrogenase in vitro. However, HO-1/STAT3 gene knockdown abolished protective effect of PPC. In conclusion, PPC confers cardioprotection by scavenging ONOO– and activating the HO-1/STAT3 pathway.-
dc.languageengen_US
dc.publisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/-
dc.relation.ispartofThe FASEB Journalen_US
dc.subjectBiology-
dc.titlePropofol post-conditioning confers ischemic cardioprotection via HO-1/STAT3 signaling: role of peroxynitriteen_US
dc.typeConference_Paperen_US
dc.identifier.emailIrwin, M: mgirwin@hku.hken_US
dc.identifier.emailWong, G: gordon@hku.hken_US
dc.identifier.emailXia, Z: zyxia@hkucc.hku.hken_US
dc.identifier.authorityIrwin, M=rp00390en_US
dc.identifier.authorityWong, G=rp00523en_US
dc.identifier.authorityXia, Z=rp00532en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros221912en_US
dc.identifier.volume27en_US
dc.identifier.issuemeeting abstracts-
dc.publisher.placeUnited States-

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