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Conference Paper: Association between vascular risk factors and incident significant cognitive impairment in Chinese older people in Hong Kong in a six-year study

TitleAssociation between vascular risk factors and incident significant cognitive impairment in Chinese older people in Hong Kong in a six-year study
Authors
Issue Date2012
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://easap.asia/index.htm
Citation
The 3rd Joint International Conference of the Hong Kong College of Psychiatrists and the Royal College of Psychiatrists (UK), Hong Kong, China, 8–10 December 2012. In East Asian Archives of Psychiatry, 2012, v. 22 suppl. 4, p. 44, abstract no. F2.2.3 How to Cite?
AbstractObjective: This study aimed to examine the association between vascular risk factors, namely hypertension, diabetes mellitus and hypercholesterolemia, and incident significant cognitive impairment in community-dwelling Chinese older people in Hong Kong. Methods: Community-dwelling Chinese older people aged 65 years and above who attended Nam Shan Elderly Health Centre in 2005 with no history of dementia or stroke constituted the baseline sample. Retrospective data retrieval for the presence of vascular risk factors at baseline was conducted. Annual clinical assessment on cognition was offered in the 6-year study period. Significant cognitive impairment was defined by presence of dementia in accordance with DSM-IV-TR, scoring below the cut-off point on the Cantonese version of the Mini-Mental State Examination, and / or a global Clinical Dementia Rating score of 1-3. Results: A total of 1925 subjects were recruited into our study; 161 (8.4%) subjects developed significant cognitive impairment in the 6-year study period. Subjects with incident significant cognitive impairment was older (75 vs. 73 years; Mann-Whitney U test, p < 0.001) with lower education attainment (30.4% vs. 23.9% of illiteracy; χ2 test, p = 0.06). However, there was no statistically significant difference in the point prevalence of pre-existing hypertension (χ2 test, p = 0.68), diabetes mellitus (χ2 test, p = 0.21), and hypercholesterolemia (χ2 test, p = 0.31) between subjects who developed significant cognitive impairment and those who remained cognitively stable. Interestingly, baseline pulse pressure, but not systolic or diastolic blood pressure, was found to be higher among subjects with incident significant cognitive impairment (70 mm Hg vs. 66 mm Hg; Mann-Whitney U test, p = 0.03). Conclusions: This study did not have evidence to show that hypertension, diabetes mellitus, and hypercholesterolemia were associated with incident significant cognitive impairment in the Chinese older people in Hong Kong. Further studies are needed to examine the role of pulse pressure in contributing to cognitive decline in late life.
Persistent Identifierhttp://hdl.handle.net/10722/190123
ISSN
2015 SCImago Journal Rankings: 0.331

 

DC FieldValueLanguage
dc.contributor.authorLee, ATCen_US
dc.contributor.authorChan, WCen_US
dc.contributor.authorChiu, HFKen_US
dc.contributor.authorRichards, Men_US
dc.contributor.authorNg, SPSen_US
dc.contributor.authorHui, LYFen_US
dc.contributor.authorChan, WMen_US
dc.contributor.authorLam, LCWen_US
dc.date.accessioned2013-09-17T15:11:07Z-
dc.date.available2013-09-17T15:11:07Z-
dc.date.issued2012en_US
dc.identifier.citationThe 3rd Joint International Conference of the Hong Kong College of Psychiatrists and the Royal College of Psychiatrists (UK), Hong Kong, China, 8–10 December 2012. In East Asian Archives of Psychiatry, 2012, v. 22 suppl. 4, p. 44, abstract no. F2.2.3en_US
dc.identifier.issn2078-9947-
dc.identifier.urihttp://hdl.handle.net/10722/190123-
dc.description.abstractObjective: This study aimed to examine the association between vascular risk factors, namely hypertension, diabetes mellitus and hypercholesterolemia, and incident significant cognitive impairment in community-dwelling Chinese older people in Hong Kong. Methods: Community-dwelling Chinese older people aged 65 years and above who attended Nam Shan Elderly Health Centre in 2005 with no history of dementia or stroke constituted the baseline sample. Retrospective data retrieval for the presence of vascular risk factors at baseline was conducted. Annual clinical assessment on cognition was offered in the 6-year study period. Significant cognitive impairment was defined by presence of dementia in accordance with DSM-IV-TR, scoring below the cut-off point on the Cantonese version of the Mini-Mental State Examination, and / or a global Clinical Dementia Rating score of 1-3. Results: A total of 1925 subjects were recruited into our study; 161 (8.4%) subjects developed significant cognitive impairment in the 6-year study period. Subjects with incident significant cognitive impairment was older (75 vs. 73 years; Mann-Whitney U test, p < 0.001) with lower education attainment (30.4% vs. 23.9% of illiteracy; χ2 test, p = 0.06). However, there was no statistically significant difference in the point prevalence of pre-existing hypertension (χ2 test, p = 0.68), diabetes mellitus (χ2 test, p = 0.21), and hypercholesterolemia (χ2 test, p = 0.31) between subjects who developed significant cognitive impairment and those who remained cognitively stable. Interestingly, baseline pulse pressure, but not systolic or diastolic blood pressure, was found to be higher among subjects with incident significant cognitive impairment (70 mm Hg vs. 66 mm Hg; Mann-Whitney U test, p = 0.03). Conclusions: This study did not have evidence to show that hypertension, diabetes mellitus, and hypercholesterolemia were associated with incident significant cognitive impairment in the Chinese older people in Hong Kong. Further studies are needed to examine the role of pulse pressure in contributing to cognitive decline in late life.-
dc.languageengen_US
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://easap.asia/index.htm-
dc.relation.ispartofEast Asian Archives of Psychiatryen_US
dc.rightsEast Asian Archives of Psychiatry. Copyright © Hong Kong Academy of Medicine Press.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleAssociation between vascular risk factors and incident significant cognitive impairment in Chinese older people in Hong Kong in a six-year studyen_US
dc.typeConference_Paperen_US
dc.identifier.emailChan, WC: waicchan@hku.hken_US
dc.identifier.authorityChan, WC=rp01687en_US
dc.description.naturepublished_or_final_version-
dc.identifier.hkuros225230en_US
dc.identifier.volume22-
dc.identifier.issuesuppl. 4-
dc.identifier.spage44, abstract no. F2.2.3-
dc.identifier.epage44, abstract no. F2.2.3-
dc.publisher.placeHong Kong-

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