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Conference Paper: Rising epidemic of HIV-1 infections among general populations in Fujian, China

TitleRising epidemic of HIV-1 infections among general populations in Fujian, China
Authors
Issue Date2012
PublisherGlobal HIV Vaccine Enterprise.
Citation
The 2012 International Meeting of AIDS Vaccine, Boston, MA., 9-12 September 2012. In AIDS Vaccine 2012 Abstracts Book, 2012, p. 164, abstract P05.01 How to Cite?
AbstractBACKGROUND: Monitoring HIV transmission and viral diversity has significant impacts on guiding effective vaccine development. Until now, few large-scale studies have investigated HIV infections among the general populations of China. METHODS: 915,830 and 2,152,658 blood samples from various groups were collected in 2006-2007 and 2008-2009, respectively, in Fujian, a low prevalent region in China. Comprehensive HIV-1 epidemiology and molecular epidemiology studies were conducted. RESULTS: Our data revealed a significant rise of the overall prevalence of infections within a short time period, from 0.064% in 2006-2007 to 0.074% in 2008-2009 (p=0.003), which resulted in the double numbers of infections from 528 in 2006-2007 to 1129 in 2008-2009. Critically, the prevalence rate among general populations such as voluntary blood donors, recipients of blood transfusion and people during pre-surgery screening had significantly increased in recent years (p<0.001). Besides CRF01_AE as the dominant circulating subtype (61/86, 70.9%), 25 non-CRF01_AE strains were found contributing to increased HIV-1 genetic diversity including C/CRF07_BC/CRF08_BC (5.8%), B/B’ (15.1%) and unique recombinant forms (8.1%). More than 30% (26/81) of subjects were found to contain various drug resistant mutations. CONCLUSION: The rising epidemic in recent years in Fujian is likely due to the increased prevalence of HIV-1 infections among general populations and multiple viral subtypes circulating. Our findings will be useful for helping to enhance the current surveillance system and to generate strategic prevention programs targeting general populations in China. Moreover, these results also have implications for AIDS vaccine research.
DescriptionPosters - Topic 5: HIV Transmission and Viral Diversity: abstract P05.01
Persistent Identifierhttp://hdl.handle.net/10722/190074

 

DC FieldValueLanguage
dc.contributor.authorWang, Hen_US
dc.contributor.authorYao, Xen_US
dc.contributor.authorYan, Pen_US
dc.contributor.authorChen, Zen_US
dc.date.accessioned2013-09-17T15:07:18Z-
dc.date.available2013-09-17T15:07:18Z-
dc.date.issued2012en_US
dc.identifier.citationThe 2012 International Meeting of AIDS Vaccine, Boston, MA., 9-12 September 2012. In AIDS Vaccine 2012 Abstracts Book, 2012, p. 164, abstract P05.01en_US
dc.identifier.urihttp://hdl.handle.net/10722/190074-
dc.descriptionPosters - Topic 5: HIV Transmission and Viral Diversity: abstract P05.01-
dc.description.abstractBACKGROUND: Monitoring HIV transmission and viral diversity has significant impacts on guiding effective vaccine development. Until now, few large-scale studies have investigated HIV infections among the general populations of China. METHODS: 915,830 and 2,152,658 blood samples from various groups were collected in 2006-2007 and 2008-2009, respectively, in Fujian, a low prevalent region in China. Comprehensive HIV-1 epidemiology and molecular epidemiology studies were conducted. RESULTS: Our data revealed a significant rise of the overall prevalence of infections within a short time period, from 0.064% in 2006-2007 to 0.074% in 2008-2009 (p=0.003), which resulted in the double numbers of infections from 528 in 2006-2007 to 1129 in 2008-2009. Critically, the prevalence rate among general populations such as voluntary blood donors, recipients of blood transfusion and people during pre-surgery screening had significantly increased in recent years (p<0.001). Besides CRF01_AE as the dominant circulating subtype (61/86, 70.9%), 25 non-CRF01_AE strains were found contributing to increased HIV-1 genetic diversity including C/CRF07_BC/CRF08_BC (5.8%), B/B’ (15.1%) and unique recombinant forms (8.1%). More than 30% (26/81) of subjects were found to contain various drug resistant mutations. CONCLUSION: The rising epidemic in recent years in Fujian is likely due to the increased prevalence of HIV-1 infections among general populations and multiple viral subtypes circulating. Our findings will be useful for helping to enhance the current surveillance system and to generate strategic prevention programs targeting general populations in China. Moreover, these results also have implications for AIDS vaccine research.-
dc.languageengen_US
dc.publisherGlobal HIV Vaccine Enterprise.-
dc.relation.ispartofInternational Meeting of AIDS Vaccine 2012en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleRising epidemic of HIV-1 infections among general populations in Fujian, Chinaen_US
dc.typeConference_Paperen_US
dc.identifier.emailChen, Z: zchenai@hku.hken_US
dc.identifier.authorityChen, Z=rp00243en_US
dc.description.naturepostprint-
dc.identifier.hkuros222312en_US
dc.identifier.spage164, abstract P05.01-
dc.identifier.epage164, abstract P05.01-

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