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Conference Paper: In vivo MR spectroscopy of bilateral hippocampi in HIV-seropositive or neurosyphilis patients at 3T

TitleIn vivo MR spectroscopy of bilateral hippocampi in HIV-seropositive or neurosyphilis patients at 3T
Authors
KeywordsHuman immunodeficiency virus
1H MRS
Neurosyphilis
Issue Date2013
PublisherAmerican Society of Neuroradiology (ASNR).
Citation
The 51st Annual Meeting of the American Society of Neuroradiology (ASNR), San Diego, CA., 20-23 May 2013. In Conference Proceeddings, 2013, p. 476-477, abstract no. eP-14 How to Cite?
AbstractPURPOSE: As a result of changing sexual behaviors which led to the human immunodeficiency virus (HIV) epidemic, neurosyphilis (NS) also has experienced a worldwide resurgence and the infections are often concurrent. Mild cognitive impairment has been observed in early stages of neurosyphilis. In this study, magnetic resonance spectroscopy (MRS) was used to investigate the effect of neurosyphilis on the bilateral hippocampi of HIV-positive patients. MATERIALS & METHODS: Experiments were performed on 12 cognitively normal patients (Mini-mental-state-examination ≥ 28; age: 42 ± 12.66 years) with HIV-seropositive or neurosyphilis positive (status defined by the 2010 Sexually Transmitted Diseases Treatment Guidelines by the Centers for Disease Control and Prevention). Of the 12 patients, six were HIV-seropositive with NS, four were HIV-seropositive without NS and two were HIV-seronegative with NS. Twenty-one healthy age-matched controls also were recruited. A 3.0T MR scanner was used (Achieva, Philips Healthcare) with an 8-channel SENSE head coil. Single-voxel-spectroscopy with short echo-time (TE) 38 ms, repetition time (TR) 2000 ms was employed. Single voxels of size 2.5 cm x 1.5 cm x 1cm were placed in the left and right hippocampi with point-resolved spectroscopy (PRESS) as volume selection method. MR spectroscopy data were analyzed with offline software jMRUI version 4.0 using absolute quantification based on quantum estimation (QUEST). Choline (Cho), creatine (Cre) and N-acetylaspartate (NAA) levels were investigated with internal water as reference. Cerebrospinal fluid normalization was done. Metabolic ratios of the above metabolites also were calculated. SPSS 18.0 was employed for statistical analysis using 2-sample t-test. The level of significance was p<0.05. RESULTS: Table 1. Mean values with standard deviations of metabolites obtained from HIV patients with or without NS, NS patients with or without HIV and their respective …
DescriptionTheme: Neuroradiology for the 21st Century
ePosters: abstract no. eP-14
Persistent Identifierhttp://hdl.handle.net/10722/189806

 

DC FieldValueLanguage
dc.contributor.authorChiu, Pen_US
dc.contributor.authorChan, Yen_US
dc.contributor.authorChan, Qen_US
dc.contributor.authorMak, Hen_US
dc.date.accessioned2013-09-17T14:59:59Z-
dc.date.available2013-09-17T14:59:59Z-
dc.date.issued2013en_US
dc.identifier.citationThe 51st Annual Meeting of the American Society of Neuroradiology (ASNR), San Diego, CA., 20-23 May 2013. In Conference Proceeddings, 2013, p. 476-477, abstract no. eP-14en_US
dc.identifier.urihttp://hdl.handle.net/10722/189806-
dc.descriptionTheme: Neuroradiology for the 21st Century-
dc.descriptionePosters: abstract no. eP-14-
dc.description.abstractPURPOSE: As a result of changing sexual behaviors which led to the human immunodeficiency virus (HIV) epidemic, neurosyphilis (NS) also has experienced a worldwide resurgence and the infections are often concurrent. Mild cognitive impairment has been observed in early stages of neurosyphilis. In this study, magnetic resonance spectroscopy (MRS) was used to investigate the effect of neurosyphilis on the bilateral hippocampi of HIV-positive patients. MATERIALS & METHODS: Experiments were performed on 12 cognitively normal patients (Mini-mental-state-examination ≥ 28; age: 42 ± 12.66 years) with HIV-seropositive or neurosyphilis positive (status defined by the 2010 Sexually Transmitted Diseases Treatment Guidelines by the Centers for Disease Control and Prevention). Of the 12 patients, six were HIV-seropositive with NS, four were HIV-seropositive without NS and two were HIV-seronegative with NS. Twenty-one healthy age-matched controls also were recruited. A 3.0T MR scanner was used (Achieva, Philips Healthcare) with an 8-channel SENSE head coil. Single-voxel-spectroscopy with short echo-time (TE) 38 ms, repetition time (TR) 2000 ms was employed. Single voxels of size 2.5 cm x 1.5 cm x 1cm were placed in the left and right hippocampi with point-resolved spectroscopy (PRESS) as volume selection method. MR spectroscopy data were analyzed with offline software jMRUI version 4.0 using absolute quantification based on quantum estimation (QUEST). Choline (Cho), creatine (Cre) and N-acetylaspartate (NAA) levels were investigated with internal water as reference. Cerebrospinal fluid normalization was done. Metabolic ratios of the above metabolites also were calculated. SPSS 18.0 was employed for statistical analysis using 2-sample t-test. The level of significance was p<0.05. RESULTS: Table 1. Mean values with standard deviations of metabolites obtained from HIV patients with or without NS, NS patients with or without HIV and their respective …-
dc.languageengen_US
dc.publisherAmerican Society of Neuroradiology (ASNR).-
dc.relation.ispartof51st ASNR Annual Meeting 2013 Proceedingsen_US
dc.subjectHuman immunodeficiency virus-
dc.subject1H MRS-
dc.subjectNeurosyphilis-
dc.titleIn vivo MR spectroscopy of bilateral hippocampi in HIV-seropositive or neurosyphilis patients at 3Ten_US
dc.typeConference_Paperen_US
dc.identifier.emailMak, H: makkf@hkucc.hku.hken_US
dc.identifier.authorityMak, H=rp00533en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros222090en_US
dc.identifier.spage476-
dc.identifier.epage477-
dc.publisher.placeUnited States-

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