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Conference Paper: Kinesin-1 is involved in chondrocytes adhesion to extracellular matrix and motility

TitleKinesin-1 is involved in chondrocytes adhesion to extracellular matrix and motility
Authors
Issue Date2013
PublisherThe Chinese University of Hong Kong.
Citation
The 2013 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 15 June 2013. Symposium Booklet, 2013, abstract P46 How to Cite?
AbstractIntercalation movement of proliferative chondrocytes is crucial for their columnar organization which is essential for proper function of growth plate cartilage. The conventional motor protein kinesin‐1 directionally transporting various cargos along microtubules might be involved in this polarized cell movement. Kinesin‐1 is suggested to transport unknown cargo(s) modulating focal adhesion (FA) turnover which is a key step in cell movement. To investigate kinesin‐1’s role in chondrocytes intercalation, we generate kinesin‐1 heavy chain (Kif5b) knockout mouse. In the growth plate of KIF5B deficient mouse, we observed abnormal cell morphology and disrupted columnar structure. Isolated mutant chondrocytes show reduced motility and adhesion ability to ECM proteins. Vinculin, the key regulator of focal adhesions, is found as a potential protein associated with KIF5B in mouse chondrocytes. Further study will investigate whether KIF5B affects chondrocytes motility and adhesion via FAs modulation.
Persistent Identifierhttp://hdl.handle.net/10722/189754

 

DC FieldValueLanguage
dc.contributor.authorXue, MWen_US
dc.contributor.authorGan, Hen_US
dc.contributor.authorZhu, GXen_US
dc.contributor.authorChan, Den_US
dc.contributor.authorCheah, Ken_US
dc.contributor.authorHuang, Jen_US
dc.date.accessioned2013-09-17T14:56:04Z-
dc.date.available2013-09-17T14:56:04Z-
dc.date.issued2013-
dc.identifier.citationThe 2013 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 15 June 2013. Symposium Booklet, 2013, abstract P46en_US
dc.identifier.urihttp://hdl.handle.net/10722/189754-
dc.description.abstractIntercalation movement of proliferative chondrocytes is crucial for their columnar organization which is essential for proper function of growth plate cartilage. The conventional motor protein kinesin‐1 directionally transporting various cargos along microtubules might be involved in this polarized cell movement. Kinesin‐1 is suggested to transport unknown cargo(s) modulating focal adhesion (FA) turnover which is a key step in cell movement. To investigate kinesin‐1’s role in chondrocytes intercalation, we generate kinesin‐1 heavy chain (Kif5b) knockout mouse. In the growth plate of KIF5B deficient mouse, we observed abnormal cell morphology and disrupted columnar structure. Isolated mutant chondrocytes show reduced motility and adhesion ability to ECM proteins. Vinculin, the key regulator of focal adhesions, is found as a potential protein associated with KIF5B in mouse chondrocytes. Further study will investigate whether KIF5B affects chondrocytes motility and adhesion via FAs modulation.-
dc.languageengen_US
dc.publisherThe Chinese University of Hong Kong.-
dc.relation.ispartofHong Kong Inter-University Biochemistry Postgraduate Symposium Booklet 2013en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleKinesin-1 is involved in chondrocytes adhesion to extracellular matrix and motilityen_US
dc.typeConference_Paperen_US
dc.identifier.emailGan, H: huiyan@hku.hken_US
dc.identifier.emailChan, D: chand@hku.hken_US
dc.identifier.emailCheah, K: hrmbdkc@hku.hken_US
dc.identifier.emailHuang, J: jdhuang@hku.hk-
dc.identifier.authorityChan, D=rp00540en_US
dc.identifier.authorityCheah, K=rp00342en_US
dc.identifier.authorityHuang, J=rp00451en_US
dc.description.naturepostprint-
dc.identifier.hkuros224442en_US
dc.identifier.hkuros240467-
dc.publisher.placeHong Kong-

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