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Conference Paper: Lycium barbarum polysaccharides mitigate chronic intermittent hypoxia induced hippocampal oxidative stress, inflammation and apoptosis in rats.

TitleLycium barbarum polysaccharides mitigate chronic intermittent hypoxia induced hippocampal oxidative stress, inflammation and apoptosis in rats.
Authors
KeywordsCardiovascular disease
Issue Date2012
PublisherHong Kong College of Cardiology. The Journal's web site is located at http://www.hkcchk.com/journals.php#3
Citation
The 16th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Hong Kong, 17 November 2012. In Journal of the Hong Kong College of Cardiology, 2012, v. 20 n. 2, p. 54, abstract CP4 How to Cite?
AbstractBACKGROUND: Chronic intermittent hypoxia (CIH), mimicking severe conditions of obstructive sleeping apnea, induces oxidative stress, inflammation and apoptosis in the hippocampus. Lycium barbarum polysaccharides (LBP) are biological significant portions of traditional Chinese herbal medicine Goji, which possess anti-oxidative and anti-inflammatory properties. OBJECTIVES: Our study aims to investigate the neuroprotective effect of LBP in CIH rats. We hypothesize that LBP ameliorate oxidative stress, inflammation and apoptosis in the hippocampus of rats exposed to CIH. METHODS: MDA assay was used to measure the lipid peroxidation extent, a marker of oxidative stress. Western blot was employed to examine the expressions level of antioxidant enzymes (SOD-1, SOD-2); inflammatory mediators (IL-1β], TNFα, COX-2); caspase-dependent extrinsic (FADD, caspase 8, Bid) and intrinsic apoptotic (Bax, Bcl2, cytochrome C) cell death (cleaved caspase 3) cascades; proliferative marker (PCNA) and trophic factor (BDNF). In situ cell death staining (TUNEL) was utilized to reveal the apoptotic situation of hippocampal subfields (DG, CA1 and CA3). RESULTS: LBP administrations remarkably attenuated the level of oxidative stress, inflammation and apoptosis in the hypoxic group. In addition, LBP significantly mitigated caspase-dependent apoptotic extrinsic and intrinsic (Bax, Bcl2, cytochrome C) cascades in the hypoxic group. Surprisingly, LBP increased the expression of proliferative marker (PCNA) and trophic factor (BDNF) in the hypoxic group. CONCLUSION: LBP are neuroprotective against CIH-induced hippocampal injury and may facilitate CIH-induced neurogenesis.
DescriptionThis journal issue contain abstracts of the 16th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine 2012
Open Access Journal
Persistent Identifierhttp://hdl.handle.net/10722/189694
ISSN
2015 SCImago Journal Rankings: 0.102

 

DC FieldValueLanguage
dc.contributor.authorLam, CSen_US
dc.contributor.authorTipoe, GLen_US
dc.contributor.authorChang, RCCen_US
dc.contributor.authorSo, KFen_US
dc.contributor.authorCheung, KHen_US
dc.contributor.authorFung, MLen_US
dc.date.accessioned2013-09-17T14:53:54Z-
dc.date.available2013-09-17T14:53:54Z-
dc.date.issued2012en_US
dc.identifier.citationThe 16th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Hong Kong, 17 November 2012. In Journal of the Hong Kong College of Cardiology, 2012, v. 20 n. 2, p. 54, abstract CP4en_US
dc.identifier.issn1027-7811-
dc.identifier.urihttp://hdl.handle.net/10722/189694-
dc.descriptionThis journal issue contain abstracts of the 16th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine 2012-
dc.descriptionOpen Access Journal-
dc.description.abstractBACKGROUND: Chronic intermittent hypoxia (CIH), mimicking severe conditions of obstructive sleeping apnea, induces oxidative stress, inflammation and apoptosis in the hippocampus. Lycium barbarum polysaccharides (LBP) are biological significant portions of traditional Chinese herbal medicine Goji, which possess anti-oxidative and anti-inflammatory properties. OBJECTIVES: Our study aims to investigate the neuroprotective effect of LBP in CIH rats. We hypothesize that LBP ameliorate oxidative stress, inflammation and apoptosis in the hippocampus of rats exposed to CIH. METHODS: MDA assay was used to measure the lipid peroxidation extent, a marker of oxidative stress. Western blot was employed to examine the expressions level of antioxidant enzymes (SOD-1, SOD-2); inflammatory mediators (IL-1β], TNFα, COX-2); caspase-dependent extrinsic (FADD, caspase 8, Bid) and intrinsic apoptotic (Bax, Bcl2, cytochrome C) cell death (cleaved caspase 3) cascades; proliferative marker (PCNA) and trophic factor (BDNF). In situ cell death staining (TUNEL) was utilized to reveal the apoptotic situation of hippocampal subfields (DG, CA1 and CA3). RESULTS: LBP administrations remarkably attenuated the level of oxidative stress, inflammation and apoptosis in the hypoxic group. In addition, LBP significantly mitigated caspase-dependent apoptotic extrinsic and intrinsic (Bax, Bcl2, cytochrome C) cascades in the hypoxic group. Surprisingly, LBP increased the expression of proliferative marker (PCNA) and trophic factor (BDNF) in the hypoxic group. CONCLUSION: LBP are neuroprotective against CIH-induced hippocampal injury and may facilitate CIH-induced neurogenesis.-
dc.languageengen_US
dc.publisherHong Kong College of Cardiology. The Journal's web site is located at http://www.hkcchk.com/journals.php#3-
dc.relation.ispartofJournal of the Hong Kong College of Cardiologyen_US
dc.subjectCardiovascular disease-
dc.titleLycium barbarum polysaccharides mitigate chronic intermittent hypoxia induced hippocampal oxidative stress, inflammation and apoptosis in rats.en_US
dc.typeConference_Paperen_US
dc.identifier.emailTipoe, GL: tgeorge@hkucc.hku.hken_US
dc.identifier.emailChang, RCC: rccchang@hku.hken_US
dc.identifier.emailSo, KF: hrmaskf@hku.hken_US
dc.identifier.emailCheung, KH: ckingho@hku.hken_US
dc.identifier.emailFung, ML: fungml@hkucc.hku.hken_US
dc.identifier.authorityTipoe, GL=rp00371en_US
dc.identifier.authorityChang, RCC=rp00470en_US
dc.identifier.authoritySo, KF=rp00329en_US
dc.identifier.authorityCheung, KH=rp01463en_US
dc.identifier.authorityFung, ML=rp00433en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros223535en_US
dc.identifier.volume20en_US
dc.identifier.issue2en_US
dc.identifier.spage54en_US
dc.identifier.epage54en_US
dc.publisher.placeHong Kong-

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