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Article: Surveillance and Genome Analysis of Human Bocavirus in Patients with Respiratory Infection in Guangzhou, China.

TitleSurveillance and Genome Analysis of Human Bocavirus in Patients with Respiratory Infection in Guangzhou, China.
Authors
Issue Date2012
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
PLoS One, 2012, v. 7 n. 9, p. e44876 How to Cite?
AbstractHuman bocavirus (HBoV) is a novel parvovirus associated with respiratory tract diseases and gastrointestinal illness in adult and pediatric patients throughout the world. To investigate the epidemiological and genetic variation of HBoV in Guangzhou, South China, we screened 3460 throat swab samples from 1686 children and 1774 adults with acute respiratory infection symptoms for HBoV between March 2010 and February 2011, and analyzed the complete genome sequence of 2 HBoV strains. Specimens were screened for HBoV by real-time PCR and other 6 common respiratory viruses by RT-PCR or PCR. HBoV was detected in 58 (1.68%) out of 3460 samples, mostly from pediatric patients (52/58) and inpatient children (47/58). Six adult patients were detected as HBoV positive and 5 were emergency cases. Of these HBoV positive cases, 19 (32.76%) had co-pathogens including influenza virus (n = 5), RSV (n = 5), parainfluenza (n = 4), adenovirus (n = 1), coronavirus (n = 7). The complete genome sequences of 2 HBoVs strains (Genbank no. JN794565 and JN794566) were analyzed. Phylogenetic analysis showed that the 2 HBoV strains were HBoV1, and were most genetically close to ST2 (GenBank accession number DQ0000496). Recombination analysis confirmed that HBoV strain GZ9081 was an intra-genotype recombinant strain among HBoV1 variants.
Persistent Identifierhttp://hdl.handle.net/10722/189291
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXu, Len_US
dc.contributor.authorHe, Xen_US
dc.contributor.authorZhang, DMen_US
dc.contributor.authorFeng, FSen_US
dc.contributor.authorWang, Zen_US
dc.contributor.authorGuan, LLen_US
dc.contributor.authorWu, JHen_US
dc.contributor.authorZhou, Ren_US
dc.contributor.authorZheng, BJen_US
dc.contributor.authorYuen, KYen_US
dc.contributor.authorLi, MFen_US
dc.contributor.authorCao, KYen_US
dc.date.accessioned2013-09-17T14:33:08Z-
dc.date.available2013-09-17T14:33:08Z-
dc.date.issued2012en_US
dc.identifier.citationPLoS One, 2012, v. 7 n. 9, p. e44876en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://hdl.handle.net/10722/189291-
dc.description.abstractHuman bocavirus (HBoV) is a novel parvovirus associated with respiratory tract diseases and gastrointestinal illness in adult and pediatric patients throughout the world. To investigate the epidemiological and genetic variation of HBoV in Guangzhou, South China, we screened 3460 throat swab samples from 1686 children and 1774 adults with acute respiratory infection symptoms for HBoV between March 2010 and February 2011, and analyzed the complete genome sequence of 2 HBoV strains. Specimens were screened for HBoV by real-time PCR and other 6 common respiratory viruses by RT-PCR or PCR. HBoV was detected in 58 (1.68%) out of 3460 samples, mostly from pediatric patients (52/58) and inpatient children (47/58). Six adult patients were detected as HBoV positive and 5 were emergency cases. Of these HBoV positive cases, 19 (32.76%) had co-pathogens including influenza virus (n = 5), RSV (n = 5), parainfluenza (n = 4), adenovirus (n = 1), coronavirus (n = 7). The complete genome sequences of 2 HBoVs strains (Genbank no. JN794565 and JN794566) were analyzed. Phylogenetic analysis showed that the 2 HBoV strains were HBoV1, and were most genetically close to ST2 (GenBank accession number DQ0000496). Recombination analysis confirmed that HBoV strain GZ9081 was an intra-genotype recombinant strain among HBoV1 variants.en_US
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.actionen_US
dc.relation.ispartofPLoS Oneen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshDNA Primers - geneticsen_US
dc.subject.meshEpidemiological Monitoringen_US
dc.subject.meshHuman bocavirus - genetics - metabolismen_US
dc.subject.meshReal-Time Polymerase Chain Reaction - methodsen_US
dc.subject.meshRespiratory Tract Infections - virologyen_US
dc.titleSurveillance and Genome Analysis of Human Bocavirus in Patients with Respiratory Infection in Guangzhou, China.en_US
dc.typeArticleen_US
dc.identifier.emailZheng, BJ: bzheng@hkucc.hku.hken_US
dc.identifier.emailYuen, KY: kyyuen@hkucc.hku.hken_US
dc.identifier.authorityZheng, BJ=rp00353en_US
dc.identifier.authorityYuen, KY=rp00366en_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1371/journal.pone.0044876en_US
dc.identifier.pmid22984581en_US
dc.identifier.pmcidPMC3439446en_US
dc.identifier.hkuros221555en_US
dc.identifier.volume7en_US
dc.identifier.issue9en_US
dc.identifier.spagee44876en_US
dc.identifier.epagee44876en_US
dc.identifier.isiWOS:000308638700096-
dc.publisher.placeUnited Statesen_US

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