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Conference Paper: Microfluidic fabrication of polymeric core-shell microspheres for controlled release applications

TitleMicrofluidic fabrication of polymeric core-shell microspheres for controlled release applications
Authors
KeywordsActive ingredients
Biomedical applications
Core-shell microspheres
Core-shell particle
Encapsulation efficiency
Microfluidic method
Narrow size distributions
Poly(lactic-co-glycolic acid)
Issue Date2013
PublisherAmerican Institute of Physics. The Journal's web site is located at http://bmf.aip.org
Citation
The 3rd European Conference on Microfluidics (μFlu'12), Heidelberg, Germany, 3-5 December 2012. In Biomicrofluidics, 2013, v. 7 n. 4, p. 044128-1 - 044128-9 How to Cite?
AbstractWe report a facile and robust microfluidic method to fabricate polymeric core-shell microspheres as delivery vehicles for biomedical applications. The characteristics of core-shell microspheres can be precisely and easily tuned by manipulating the microfluidic double emulsion templates. The addition of a shell can significantly improve the versatility as well as functionality of these microspheres as delivery vehicles. We demonstrate that the nature of the shell material plays an important role in the properties of the core-shell delivery vehicles. The release kinetics is significantly influenced by the material of the shell and other characteristics such as the thickness. For example, by adding a poly(lactic-co-glycolic acid) (PLGA) shell to an alginate core, the encapsulation efficiency is enhanced and undesired leakage of hydrophilic actives is prevented. By contrast, adding an alginate shell to PLGA core can lead to a reduction of the initial release rate, thus extending the release period of hydrophobic actives. Microfluidic fabrication enables the generation of precisely controlled core-shell microspheres with a narrow size distribution, which enables the investigation of the relationship between the release kinetics of these microspheres and their characteristics. The approach of using core-shell particles as delivery vehicles creates new opportunities to customize the release kinetics of active ingredients. © 2013 AIP Publishing LLC.
DescriptionFootnote in article: Paper submitted as part of the 3rd European Conference on Microfluidics ... 2012
Persistent Identifierhttp://hdl.handle.net/10722/189158
ISSN
2015 Impact Factor: 2.708
2015 SCImago Journal Rankings: 0.794
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKong, Ten_US
dc.contributor.authorWu, Jen_US
dc.contributor.authorYeung, KWKen_US
dc.contributor.authorTo, MKTen_US
dc.contributor.authorShum, HCen_US
dc.contributor.authorWang, Len_US
dc.date.accessioned2013-09-17T14:28:43Z-
dc.date.available2013-09-17T14:28:43Z-
dc.date.issued2013-
dc.identifier.citationThe 3rd European Conference on Microfluidics (μFlu'12), Heidelberg, Germany, 3-5 December 2012. In Biomicrofluidics, 2013, v. 7 n. 4, p. 044128-1 - 044128-9en_US
dc.identifier.issn1932-1058-
dc.identifier.urihttp://hdl.handle.net/10722/189158-
dc.descriptionFootnote in article: Paper submitted as part of the 3rd European Conference on Microfluidics ... 2012-
dc.description.abstractWe report a facile and robust microfluidic method to fabricate polymeric core-shell microspheres as delivery vehicles for biomedical applications. The characteristics of core-shell microspheres can be precisely and easily tuned by manipulating the microfluidic double emulsion templates. The addition of a shell can significantly improve the versatility as well as functionality of these microspheres as delivery vehicles. We demonstrate that the nature of the shell material plays an important role in the properties of the core-shell delivery vehicles. The release kinetics is significantly influenced by the material of the shell and other characteristics such as the thickness. For example, by adding a poly(lactic-co-glycolic acid) (PLGA) shell to an alginate core, the encapsulation efficiency is enhanced and undesired leakage of hydrophilic actives is prevented. By contrast, adding an alginate shell to PLGA core can lead to a reduction of the initial release rate, thus extending the release period of hydrophobic actives. Microfluidic fabrication enables the generation of precisely controlled core-shell microspheres with a narrow size distribution, which enables the investigation of the relationship between the release kinetics of these microspheres and their characteristics. The approach of using core-shell particles as delivery vehicles creates new opportunities to customize the release kinetics of active ingredients. © 2013 AIP Publishing LLC.-
dc.languageengen_US
dc.publisherAmerican Institute of Physics. The Journal's web site is located at http://bmf.aip.org-
dc.relation.ispartofBiomicrofluidicsen_US
dc.rightsBiomicrofluidics. Copyright © American Institute of Physics.-
dc.rightsCopyright 2013 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in Biomicrofluidics, 2013, v. 7 n. 4, article 044128, p. 044128-1-044128-9 and may be found at http://dx.doi.org/10.1063/1.4819274.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectActive ingredients-
dc.subjectBiomedical applications-
dc.subjectCore-shell microspheres-
dc.subjectCore-shell particle-
dc.subjectEncapsulation efficiency-
dc.subjectMicrofluidic method-
dc.subjectNarrow size distributions-
dc.subjectPoly(lactic-co-glycolic acid)-
dc.titleMicrofluidic fabrication of polymeric core-shell microspheres for controlled release applicationsen_US
dc.typeConference_Paperen_US
dc.identifier.emailWu, J: jwuhku@hku.hken_US
dc.identifier.emailYeung, KWK: wkkyeung@hku.hken_US
dc.identifier.emailTo, MKT: mikektto@hku.hken_US
dc.identifier.emailShum, HC: ashum@hku.hken_US
dc.identifier.emailWang, L: lqwang@hku.hk-
dc.identifier.authorityYeung, KWK=rp00309en_US
dc.identifier.authorityTo, MKT=rp00302en_US
dc.identifier.authorityShum, HC=rp01439en_US
dc.identifier.authorityWang, L=rp00184en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1063/1.4819274-
dc.identifier.pmid24404061-
dc.identifier.pmcidPMC3772936-
dc.identifier.scopuseid_2-s2.0-84883355633-
dc.identifier.hkuros221249en_US
dc.identifier.hkuros223198-
dc.identifier.hkuros240078-
dc.identifier.volume7-
dc.identifier.issue4-
dc.identifier.spage044128-1-
dc.identifier.epage044128-9-
dc.identifier.isiWOS:000323907600030-
dc.publisher.placeUnited States-
dc.customcontrol.immutablesml 140102-

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