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Article: Targeting of DICE1 tumor suppressor by Epstein-Barr virus-encoded miR-BART3* microRNA in nasopharyngeal carcinoma

TitleTargeting of DICE1 tumor suppressor by Epstein-Barr virus-encoded miR-BART3* microRNA in nasopharyngeal carcinoma
Authors
Issue Date2013
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home
Citation
International Journal of Cancer, 2013, v. 133 n. 1, p. 79-87 How to Cite?
AbstractLatent infection with Epstein-Barr virus (EBV) is associated with several types of malignancies including nasopharyngeal carcinoma (NPC), which is particularly more prevalent in Southern China. EBV expresses at least 44 mature microRNAs (miRNAs) to modulate the activity of viral and cellular RNAs, but the targets of these EBV-encoded miRNAs in NPC are not well understood. In this report, we characterized DICE1 tumor suppressor to be a cellular target of EBV miR-BART3* miRNA. miR-BART3* was abundantly expressed in NPC cells. The target site of miR-BART3* located in the 3'-untranslated region of DICE1 transcript was identified and characterized. Enforced expression of miR-BART3* or its precursor pre-miR-BART3 led to down-regulation of endogenous DICE1 expression. Inhibition of endogenous miR-BART3* in NPC cells with anti-miR-BART3* oligonucleotide inhibitor resulted in increased expression of DICE1 protein. On the contrary, expression of miR-BART3* overcame the growth suppressive activity of DICE1 and stimulated cell proliferation. Consistent with its tumor suppressive function, DICE1 was underexpressed in EBV-expressing NPC tumor tissues. Taken together, our findings suggest that EBV encoded miR-BART3* miRNA targets DICE1 tumor suppressor to promote cellular growth and transformation in NPC.
Persistent Identifierhttp://hdl.handle.net/10722/188858
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.657
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLei, Ten_US
dc.contributor.authorYuen, KSen_US
dc.contributor.authorXu, Ren_US
dc.contributor.authorTsao, GSWen_US
dc.contributor.authorChen, Hen_US
dc.contributor.authorLi, Men_US
dc.contributor.authorKok, KHen_US
dc.contributor.authorJin, Den_US
dc.date.accessioned2013-09-17T14:17:38Z-
dc.date.available2013-09-17T14:17:38Z-
dc.date.issued2013en_US
dc.identifier.citationInternational Journal of Cancer, 2013, v. 133 n. 1, p. 79-87en_US
dc.identifier.issn0020-7136-
dc.identifier.urihttp://hdl.handle.net/10722/188858-
dc.description.abstractLatent infection with Epstein-Barr virus (EBV) is associated with several types of malignancies including nasopharyngeal carcinoma (NPC), which is particularly more prevalent in Southern China. EBV expresses at least 44 mature microRNAs (miRNAs) to modulate the activity of viral and cellular RNAs, but the targets of these EBV-encoded miRNAs in NPC are not well understood. In this report, we characterized DICE1 tumor suppressor to be a cellular target of EBV miR-BART3* miRNA. miR-BART3* was abundantly expressed in NPC cells. The target site of miR-BART3* located in the 3'-untranslated region of DICE1 transcript was identified and characterized. Enforced expression of miR-BART3* or its precursor pre-miR-BART3 led to down-regulation of endogenous DICE1 expression. Inhibition of endogenous miR-BART3* in NPC cells with anti-miR-BART3* oligonucleotide inhibitor resulted in increased expression of DICE1 protein. On the contrary, expression of miR-BART3* overcame the growth suppressive activity of DICE1 and stimulated cell proliferation. Consistent with its tumor suppressive function, DICE1 was underexpressed in EBV-expressing NPC tumor tissues. Taken together, our findings suggest that EBV encoded miR-BART3* miRNA targets DICE1 tumor suppressor to promote cellular growth and transformation in NPC.-
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home-
dc.relation.ispartofInternational Journal of Canceren_US
dc.rightsInternational Journal of Cancer. Copyright © John Wiley & Sons, Inc..-
dc.subject.meshEpstein-Barr Virus Infections - complications - metabolism-
dc.subject.meshGene Silencing-
dc.subject.meshHerpesvirus 4, Human-
dc.subject.meshMicroRNAs - genetics - metabolism-
dc.subject.meshNasopharyngeal Neoplasms - virology-
dc.titleTargeting of DICE1 tumor suppressor by Epstein-Barr virus-encoded miR-BART3* microRNA in nasopharyngeal carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailTsao, GSW: gswtsao@hku.hken_US
dc.identifier.emailChen, H: hlchen@hku.hken_US
dc.identifier.emailKok, KH: khkok@hku.hken_US
dc.identifier.emailJin, D: dyjin@hku.hken_US
dc.identifier.authorityTsao, GSW=rp00399en_US
dc.identifier.authorityChen, H=rp00383en_US
dc.identifier.authorityKok, KH=rp01455en_US
dc.identifier.authorityJin, D=rp00452en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/ijc.28007-
dc.identifier.pmid23280823-
dc.identifier.scopuseid_2-s2.0-84876694817-
dc.identifier.hkuros224755en_US
dc.identifier.hkuros234958-
dc.identifier.volume133en_US
dc.identifier.issue1-
dc.identifier.spage79en_US
dc.identifier.epage87en_US
dc.identifier.isiWOS:000318112200008-
dc.publisher.placeUnited States-

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