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Article: Role of Forkhead Transcription Factors in Myocardial Ischemic Reperfusion Injury in Diabetes

TitleRole of Forkhead Transcription Factors in Myocardial Ischemic Reperfusion Injury in Diabetes
Authors
KeywordsFoxO
Diabetes
Ischemia/reperfusion injury
Issue Date2013
PublisherOMICS publishing group. The Journal's web site is located at http://www.omicsonline.org/jdmhome.php
Citation
Journal of Diabetes & Metabolism, 2013, v. 4 n. 3, article no. 1000247 How to Cite?
AbstractDiabetes, characterized by hyperglycemia resulting from either insulin deficiency or insulin resistance, is a chronic metabolic disorder. Hearts of subjects with diabetes are more sensitive to myocardial ischemia/reperfusion injury but the underlying mechanism is largely unclear. Recent evidence suggests that alteration in cardiac metabolism is a key contributor to the increased vulnerability of diabetic heart to ischemia/reperfusion injury. The FoxO family of forkhead transcription factors including FoxO1, 3 and 4 play important roles in the regulation of many cellular and biological processes and are critical regulators of cardiac metabolism and cellular oxidative stress in the heart. This brief review focuses on the role of FoxO in regulating cardiac metabolism and its association with myocardial ischemia/reperfusion injury, especially in diabetes.
Persistent Identifierhttp://hdl.handle.net/10722/188832
ISSN

 

DC FieldValueLanguage
dc.contributor.authorLI, Hen_US
dc.contributor.authorIrwin, MGen_US
dc.contributor.authorTao, Men_US
dc.contributor.authorLi, Yen_US
dc.contributor.authorZhang, Len_US
dc.contributor.authorXia, Zen_US
dc.date.accessioned2013-09-17T14:16:46Z-
dc.date.available2013-09-17T14:16:46Z-
dc.date.issued2013en_US
dc.identifier.citationJournal of Diabetes & Metabolism, 2013, v. 4 n. 3, article no. 1000247en_US
dc.identifier.issn2155-6156-
dc.identifier.urihttp://hdl.handle.net/10722/188832-
dc.description.abstractDiabetes, characterized by hyperglycemia resulting from either insulin deficiency or insulin resistance, is a chronic metabolic disorder. Hearts of subjects with diabetes are more sensitive to myocardial ischemia/reperfusion injury but the underlying mechanism is largely unclear. Recent evidence suggests that alteration in cardiac metabolism is a key contributor to the increased vulnerability of diabetic heart to ischemia/reperfusion injury. The FoxO family of forkhead transcription factors including FoxO1, 3 and 4 play important roles in the regulation of many cellular and biological processes and are critical regulators of cardiac metabolism and cellular oxidative stress in the heart. This brief review focuses on the role of FoxO in regulating cardiac metabolism and its association with myocardial ischemia/reperfusion injury, especially in diabetes.-
dc.languageengen_US
dc.publisherOMICS publishing group. The Journal's web site is located at http://www.omicsonline.org/jdmhome.php-
dc.relation.ispartofJournal of Diabetes & Metabolismen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectFoxO-
dc.subjectDiabetes-
dc.subjectIschemia/reperfusion injury-
dc.titleRole of Forkhead Transcription Factors in Myocardial Ischemic Reperfusion Injury in Diabetesen_US
dc.typeArticleen_US
dc.identifier.emailIrwin, MG: mgirwin@hku.hken_US
dc.identifier.emailXia, Z: zyxia@hkucc.hku.hken_US
dc.identifier.authorityIrwin, MG=rp00390en_US
dc.identifier.authorityXia, Z=rp00532en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.4172/2155-6156.1000247-
dc.identifier.hkuros221848en_US
dc.identifier.hkuros261692-
dc.identifier.volume4en_US
dc.identifier.issue3-
dc.identifier.spagearticle no. 1000247en_US
dc.identifier.epagearticle no. 1000247en_US
dc.publisher.placeUnited States-

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