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Article: Does acupuncture therapy alter activation of neural pathway for pain perception in irritable bowel syndrome?: A comparative study of true and sham acupuncture using functional magnetic resonance imaging

TitleDoes acupuncture therapy alter activation of neural pathway for pain perception in irritable bowel syndrome?: A comparative study of true and sham acupuncture using functional magnetic resonance imaging
Authors
KeywordsAcupuncture
Irritable Bowel Syndrome
Magnetic Resonance Imaging
Issue Date2012
Citation
Journal Of Neurogastroenterology And Motility, 2012, v. 18 n. 3, p. 305-316 How to Cite?
AbstractBackground/Aims: Patients with irritable bowel syndrome (IBS) are characterized by abnormal central processing with altered brain activation in response to visceral nociceptive signals. The effect of electroacupuncture (EA) on IBS patients is unclear. The study is set to study the effect of EA on brain activation during noxious rectal distension in IBS patients using a randomized sham-controlled model. Methods: Thirty IBS-diarrhea patients were randomized to true electroacupuncture or sham acupuncture. Functional MRI was performed to evaluate cerebral activation at the following time points: (1) baseline when there was rectal distension only, (2) rectal distension during application of EA, (3) rectal distension after cessation of EA and (4) EA alone with no rectal distension. Group comparison was made under each condition using SPM5 program. Results: Rectal distension induced significant activation of the anterior cingulated cortex, prefrontal cortex, thalamus, temporal regions and cerebellum at baseline. During and immediately after EA, increased cerebral activation from baseline was observed in the anterior cingulated cortex, bilateral prefrontal cortex, thalamus, temporal regions and right insula in both groups. However, true electroacupuncture led to significantly higher activation at right insula, as well as pulvinar and medial nucleus of the thalamus when compared to sham acupuncture. Conclusions: We postulate that acupuncture might have the potential effect of pain modulation in IBS by 2 actions: (1) modulation of serotonin pathway at insula and (2) modulation of mood and affection in higher cortical center via ascending pathway at the pulvinar and medial nucleus of the thalamus. © 2012 The Korean Society of Neurogastroenterology and Motility.
Persistent Identifierhttp://hdl.handle.net/10722/188661
ISSN
2015 Impact Factor: 1.771
2015 SCImago Journal Rankings: 0.710
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChu, WCWen_US
dc.contributor.authorWu, JCYen_US
dc.contributor.authorYew, DTWen_US
dc.contributor.authorZhang, Len_US
dc.contributor.authorShi, Len_US
dc.contributor.authorYeung, DKWen_US
dc.contributor.authorWang, Den_US
dc.contributor.authorTong, RKYen_US
dc.contributor.authorChan, Yen_US
dc.contributor.authorLao, Len_US
dc.contributor.authorLeung, PCen_US
dc.contributor.authorBerman, BMen_US
dc.contributor.authorSung, JJYen_US
dc.date.accessioned2013-09-03T04:10:55Z-
dc.date.available2013-09-03T04:10:55Z-
dc.date.issued2012en_US
dc.identifier.citationJournal Of Neurogastroenterology And Motility, 2012, v. 18 n. 3, p. 305-316en_US
dc.identifier.issn2093-0879en_US
dc.identifier.urihttp://hdl.handle.net/10722/188661-
dc.description.abstractBackground/Aims: Patients with irritable bowel syndrome (IBS) are characterized by abnormal central processing with altered brain activation in response to visceral nociceptive signals. The effect of electroacupuncture (EA) on IBS patients is unclear. The study is set to study the effect of EA on brain activation during noxious rectal distension in IBS patients using a randomized sham-controlled model. Methods: Thirty IBS-diarrhea patients were randomized to true electroacupuncture or sham acupuncture. Functional MRI was performed to evaluate cerebral activation at the following time points: (1) baseline when there was rectal distension only, (2) rectal distension during application of EA, (3) rectal distension after cessation of EA and (4) EA alone with no rectal distension. Group comparison was made under each condition using SPM5 program. Results: Rectal distension induced significant activation of the anterior cingulated cortex, prefrontal cortex, thalamus, temporal regions and cerebellum at baseline. During and immediately after EA, increased cerebral activation from baseline was observed in the anterior cingulated cortex, bilateral prefrontal cortex, thalamus, temporal regions and right insula in both groups. However, true electroacupuncture led to significantly higher activation at right insula, as well as pulvinar and medial nucleus of the thalamus when compared to sham acupuncture. Conclusions: We postulate that acupuncture might have the potential effect of pain modulation in IBS by 2 actions: (1) modulation of serotonin pathway at insula and (2) modulation of mood and affection in higher cortical center via ascending pathway at the pulvinar and medial nucleus of the thalamus. © 2012 The Korean Society of Neurogastroenterology and Motility.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Neurogastroenterology and Motilityen_US
dc.subjectAcupunctureen_US
dc.subjectIrritable Bowel Syndromeen_US
dc.subjectMagnetic Resonance Imagingen_US
dc.titleDoes acupuncture therapy alter activation of neural pathway for pain perception in irritable bowel syndrome?: A comparative study of true and sham acupuncture using functional magnetic resonance imagingen_US
dc.typeArticleen_US
dc.identifier.emailLao, L: lxlao1@hku.hken_US
dc.identifier.authorityLao, L=rp01784en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.5056/jnm.2012.18.3.305en_US
dc.identifier.pmid22837879-
dc.identifier.scopuseid_2-s2.0-84872855549en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84872855549&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume18en_US
dc.identifier.issue3en_US
dc.identifier.spage305en_US
dc.identifier.epage316en_US
dc.identifier.isiWOS:000325000800011-
dc.identifier.scopusauthoridChu, WCW=7402227871en_US
dc.identifier.scopusauthoridWu, JCY=34870755800en_US
dc.identifier.scopusauthoridYew, DTW=7007034694en_US
dc.identifier.scopusauthoridZhang, L=55569518600en_US
dc.identifier.scopusauthoridShi, L=55561144500en_US
dc.identifier.scopusauthoridYeung, DKW=35290812300en_US
dc.identifier.scopusauthoridWang, D=13105571800en_US
dc.identifier.scopusauthoridTong, RKY=55568619600en_US
dc.identifier.scopusauthoridChan, Y=9235776200en_US
dc.identifier.scopusauthoridLao, L=7005681883en_US
dc.identifier.scopusauthoridLeung, PC=55489542000en_US
dc.identifier.scopusauthoridBerman, BM=35458606800en_US
dc.identifier.scopusauthoridSung, JJY=55455319600en_US

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