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Article: Modified Huo-Luo-Xiao-Ling dan suppresses adjuvant arthritis by inhibiting chemokines and matrix-degrading enzymes

TitleModified Huo-Luo-Xiao-Ling dan suppresses adjuvant arthritis by inhibiting chemokines and matrix-degrading enzymes
Authors
Issue Date2012
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/ecam/
Citation
Evidence-Based Complementary And Alternative Medicine, 2012, v. 2012 How to Cite?
AbstractRheumatoid arthritis (RA) is a chronic inflammatory disease affecting the joints that can lead to deformities and disability. The prolonged use of conventionally used drugs is associated with severe adverse reactions. Therefore, safer and less expensive therapeutic products are continually being sought. Huo-Luo-Xiao-Ling dan (HLXL), a traditional Chinese herbal mixture, and its modified versions possess anti-arthritic activity. In this paper, we examined the influence of modified HLXL on two of the key mediators of arthritic inflammation and tissue damage, namely, chemokines and matrix- metalloproteinases (MMPs) in the rat adjuvant-induced arthritis (AA) model of RA. We treated arthritic Lewis rats with HLXL (2.3g/kg) by daily gavage beginning at the onset of AA. The control rats received the vehicle. At the peak phase of AA, rats were sacrificed and their draining lymph node cells (LNC) and spleen adherent cells (SAC) were tested. The HLXL-treated rats showed a significant reduction in the levels of chemokines (RANTES, MCP-1, MIP-1α, and GRO/KC), MMPs (MMP 2 and 9), as well as cytokines (IL-6 and IL-17) that induce them, compared to the control vehicle-treated rats. Thus, HLXL controls arthritis in part by suppressing the mediators of immune pathology, and it might offer a promising alternative/adjunct treatment for RA. Copyright © 2012 Siddaraju M. Nanjundaiah et al.
Persistent Identifierhttp://hdl.handle.net/10722/188648
ISSN
2015 Impact Factor: 1.931
2015 SCImago Journal Rankings: 0.615
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorNanjundaiah, SMen_US
dc.contributor.authorLee, DYWen_US
dc.contributor.authorMa, Zen_US
dc.contributor.authorFong, HHSen_US
dc.contributor.authorLao, Len_US
dc.contributor.authorBerman, BMen_US
dc.contributor.authorMoudgil, KDen_US
dc.date.accessioned2013-09-03T04:10:50Z-
dc.date.available2013-09-03T04:10:50Z-
dc.date.issued2012en_US
dc.identifier.citationEvidence-Based Complementary And Alternative Medicine, 2012, v. 2012en_US
dc.identifier.issn1741-427Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/188648-
dc.description.abstractRheumatoid arthritis (RA) is a chronic inflammatory disease affecting the joints that can lead to deformities and disability. The prolonged use of conventionally used drugs is associated with severe adverse reactions. Therefore, safer and less expensive therapeutic products are continually being sought. Huo-Luo-Xiao-Ling dan (HLXL), a traditional Chinese herbal mixture, and its modified versions possess anti-arthritic activity. In this paper, we examined the influence of modified HLXL on two of the key mediators of arthritic inflammation and tissue damage, namely, chemokines and matrix- metalloproteinases (MMPs) in the rat adjuvant-induced arthritis (AA) model of RA. We treated arthritic Lewis rats with HLXL (2.3g/kg) by daily gavage beginning at the onset of AA. The control rats received the vehicle. At the peak phase of AA, rats were sacrificed and their draining lymph node cells (LNC) and spleen adherent cells (SAC) were tested. The HLXL-treated rats showed a significant reduction in the levels of chemokines (RANTES, MCP-1, MIP-1α, and GRO/KC), MMPs (MMP 2 and 9), as well as cytokines (IL-6 and IL-17) that induce them, compared to the control vehicle-treated rats. Thus, HLXL controls arthritis in part by suppressing the mediators of immune pathology, and it might offer a promising alternative/adjunct treatment for RA. Copyright © 2012 Siddaraju M. Nanjundaiah et al.en_US
dc.languageengen_US
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/ecam/en_US
dc.relation.ispartofEvidence-based Complementary and Alternative Medicineen_US
dc.titleModified Huo-Luo-Xiao-Ling dan suppresses adjuvant arthritis by inhibiting chemokines and matrix-degrading enzymesen_US
dc.typeArticleen_US
dc.identifier.emailLao, L: lxlao1@hku.hken_US
dc.identifier.authorityLao, L=rp01784en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1155/2012/589256en_US
dc.identifier.scopuseid_2-s2.0-84859773919en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84859773919&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume2012en_US
dc.identifier.isiWOS:000302601000001-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridNanjundaiah, SM=37114747400en_US
dc.identifier.scopusauthoridLee, DYW=24465228000en_US
dc.identifier.scopusauthoridMa, Z=8709903000en_US
dc.identifier.scopusauthoridFong, HHS=34569199300en_US
dc.identifier.scopusauthoridLao, L=7005681883en_US
dc.identifier.scopusauthoridBerman, BM=35458606800en_US
dc.identifier.scopusauthoridMoudgil, KD=7003544028en_US

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