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Article: A new rat model of bone cancer pain

TitleA new rat model of bone cancer pain
Authors
Issue Date2012
Citation
Methods In Molecular Biology, 2012, v. 851, p. 261-273 How to Cite?
AbstractPain is a major symptom of bone cancer. Bone cancer pain significantly affects quality of life, but its underlying mechanisms have not been defined. Because skeletal metastases are particularly common in patients with prostate cancer, a model that mimics bone cancer pain has been established by injecting AT-3.1 prostate cancer cells into the tibia of the male Copenhagen rat. The model shows progressive hyperalgesia and allodynia that are associated with the gradual destruction of the tibia and can be used to study the mechanisms, such as glial activation, of these disorders. © 2012 Springer Science+Business Media, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/188645
ISSN
2015 SCImago Journal Rankings: 0.549
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, Ren_US
dc.contributor.authorLao, Len_US
dc.date.accessioned2013-09-03T04:10:47Z-
dc.date.available2013-09-03T04:10:47Z-
dc.date.issued2012en_US
dc.identifier.citationMethods In Molecular Biology, 2012, v. 851, p. 261-273en_US
dc.identifier.issn1064-3745en_US
dc.identifier.urihttp://hdl.handle.net/10722/188645-
dc.description.abstractPain is a major symptom of bone cancer. Bone cancer pain significantly affects quality of life, but its underlying mechanisms have not been defined. Because skeletal metastases are particularly common in patients with prostate cancer, a model that mimics bone cancer pain has been established by injecting AT-3.1 prostate cancer cells into the tibia of the male Copenhagen rat. The model shows progressive hyperalgesia and allodynia that are associated with the gradual destruction of the tibia and can be used to study the mechanisms, such as glial activation, of these disorders. © 2012 Springer Science+Business Media, LLC.en_US
dc.languageengen_US
dc.relation.ispartofMethods in Molecular Biologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBone Neoplasms - Complications - Pathology - Physiopathologyen_US
dc.subject.meshCell Line, Tumoren_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshHyperalgesia - Pathology - Physiopathologyen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshMaleen_US
dc.subject.meshPain - Etiology - Pathology - Physiopathologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Inbred Strainsen_US
dc.subject.meshTibia - Pathology - Physiopathologyen_US
dc.titleA new rat model of bone cancer painen_US
dc.typeArticleen_US
dc.identifier.emailLao, L: lxlao1@hku.hken_US
dc.identifier.authorityLao, L=rp01784en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/978-1-61779-561-9_20en_US
dc.identifier.pmid22351098-
dc.identifier.scopuseid_2-s2.0-84858120644en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84858120644&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume851en_US
dc.identifier.spage261en_US
dc.identifier.epage273en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridZhang, R=7404864527en_US
dc.identifier.scopusauthoridLao, L=7005681883en_US

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