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Article: A Chinese herbal formula to improve general psychological status in posttraumatic stress disorder: A randomized placebo-controlled trial on Sichuan earthquake survivors

TitleA Chinese herbal formula to improve general psychological status in posttraumatic stress disorder: A randomized placebo-controlled trial on Sichuan earthquake survivors
Authors
Issue Date2012
PublisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/ecam/
Citation
Evidence-Based Complementary And Alternative Medicine, 2012, v. 2012 How to Cite?
AbstractIntroduction. Posttraumatic stress disorder (PTSD) is accompanied by poor general psychological status (GPS). In the present study, we investigated the effects of a Chinese herbal formula on GPS in earthquake survivors with PTSD. Methods. A randomized, double-blind, placebo-controlled trial compared a Chinese herbal formula, Xiao-Tan-Jie-Yu-Fang (XTJYF), to placebo in 2008 Sichuan earthquake survivors with PTSD. Patients were randomized into XTJYF (n = 123) and placebo (n = 122) groups. Baseline-to-end-point score changes in the three global indices of the Symptom Checklist-90-Revised (SCL-90-R) and rates of response in the SCL global severity index (GSI) were the primary endpoints. A subanalysis of the nine SCL factors and the sleep quality score were secondary endpoints. Results and Discussion. Compared to placebo, the XTJYF group was significantly improved in all three SCL global indices (P = 0.0010.028). More patients in the XTJYF group reported much improved than the placebo group (P = 0.001). The XTJYF group performed significantly better than control in five out of nine SCL factors (somatization, obsessive-compulsive behavior, depression, anxiety, and hostility (P = 0.0010.036)), and in sleep quality score (P 0.001). XTJYF produced no serious adverse events. These findings suggest that XTJYF may be an effective and safe treatment option for improving GPS in patients with PTSD. © 2012 Xian-Ze Meng et al.
Persistent Identifierhttp://hdl.handle.net/10722/188640
ISSN
2015 Impact Factor: 1.931
2015 SCImago Journal Rankings: 0.615
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMeng, XZen_US
dc.contributor.authorWu, Fen_US
dc.contributor.authorWei, PKen_US
dc.contributor.authorXiu, LJen_US
dc.contributor.authorShi, Jen_US
dc.contributor.authorPang, Ben_US
dc.contributor.authorSun, DZen_US
dc.contributor.authorQin, ZFen_US
dc.contributor.authorHuang, Yen_US
dc.contributor.authorLao, Len_US
dc.date.accessioned2013-09-03T04:10:46Z-
dc.date.available2013-09-03T04:10:46Z-
dc.date.issued2012en_US
dc.identifier.citationEvidence-Based Complementary And Alternative Medicine, 2012, v. 2012en_US
dc.identifier.issn1741-427Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/188640-
dc.description.abstractIntroduction. Posttraumatic stress disorder (PTSD) is accompanied by poor general psychological status (GPS). In the present study, we investigated the effects of a Chinese herbal formula on GPS in earthquake survivors with PTSD. Methods. A randomized, double-blind, placebo-controlled trial compared a Chinese herbal formula, Xiao-Tan-Jie-Yu-Fang (XTJYF), to placebo in 2008 Sichuan earthquake survivors with PTSD. Patients were randomized into XTJYF (n = 123) and placebo (n = 122) groups. Baseline-to-end-point score changes in the three global indices of the Symptom Checklist-90-Revised (SCL-90-R) and rates of response in the SCL global severity index (GSI) were the primary endpoints. A subanalysis of the nine SCL factors and the sleep quality score were secondary endpoints. Results and Discussion. Compared to placebo, the XTJYF group was significantly improved in all three SCL global indices (P = 0.0010.028). More patients in the XTJYF group reported much improved than the placebo group (P = 0.001). The XTJYF group performed significantly better than control in five out of nine SCL factors (somatization, obsessive-compulsive behavior, depression, anxiety, and hostility (P = 0.0010.036)), and in sleep quality score (P 0.001). XTJYF produced no serious adverse events. These findings suggest that XTJYF may be an effective and safe treatment option for improving GPS in patients with PTSD. © 2012 Xian-Ze Meng et al.en_US
dc.languageengen_US
dc.publisherHindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/ecam/en_US
dc.relation.ispartofEvidence-based Complementary and Alternative Medicineen_US
dc.titleA Chinese herbal formula to improve general psychological status in posttraumatic stress disorder: A randomized placebo-controlled trial on Sichuan earthquake survivorsen_US
dc.typeArticleen_US
dc.identifier.emailLao, L: lxlao1@hku.hken_US
dc.identifier.authorityLao, L=rp01784en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1155/2012/691258en_US
dc.identifier.scopuseid_2-s2.0-84855172060en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84855172060&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume2012en_US
dc.identifier.isiWOS:000298613300001-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridMeng, XZ=53064279800en_US
dc.identifier.scopusauthoridWu, F=55700750500en_US
dc.identifier.scopusauthoridWei, PK=8976704400en_US
dc.identifier.scopusauthoridXiu, LJ=24081683600en_US
dc.identifier.scopusauthoridShi, J=14030492500en_US
dc.identifier.scopusauthoridPang, B=35796181900en_US
dc.identifier.scopusauthoridSun, DZ=8987439300en_US
dc.identifier.scopusauthoridQin, ZF=8976704500en_US
dc.identifier.scopusauthoridHuang, Y=37064693100en_US
dc.identifier.scopusauthoridLao, L=7005681883en_US

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