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Article: Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons

TitleStimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons
Authors
Issue Date2009
PublisherIOS Press. The Journal's web site is located at http://www.iospress.nl/html/13872877.php
Citation
Journal Of Alzheimer's Disease, 2009, v. 18 n. 4, p. 787-798 How to Cite?
AbstractLoss of synapses has been correlated with dementia in Alzheimer's disease (AD) as an early event during the disease progression. Hence, synaptogenesis and neurogenesis in adulthood could serve as a therapeutic target for the prevention and treatment of AD. Recently, we have demonstrated enhanced hippocampal neurogenesis by oral administration of Ginkgo biloba extract (EGb 761) to a mouse model of AD. This study aims to identify the constituents that contribute to EGb 761-induced neurogenesis. Among the constituents tested, bilobalide and quercetin significantly increased cell proliferation in the hippocampal neurons in a dose-dependent manner. Bilobalide and quercetin also enhanced phosphorylation of cyclic-AMP Response Element Binding Protein (CREB) in these cells, and elevated the levels of pCREB and, brain-derived neurotrophic factor in mice brain. Immunofluorescence staining of synaptic markers shows remarkable dendritic processes in hippocampal neurons treated with either quercetin or bilobalide. Furthermore, both constituents restored amyloid-β oligomers (also known as ADDL)-induced synaptic loss and phosphorylation of CREB. The present findings suggest that enhanced neurogenesis and synaptogenesis by bilobalide and quercetin may share a common final signaling pathway mediated by phosphorylation of CREB. Despite a recent report showing that EGb 761 was insufficient in prevent dementia, its constituents still warrant future investigation. © 2009-IOS Press and the authors. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/188615
ISSN
2015 Impact Factor: 3.92
2015 SCImago Journal Rankings: 1.774
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTchantchou, Fen_US
dc.contributor.authorLacor, PNen_US
dc.contributor.authorCao, Zen_US
dc.contributor.authorLao, Len_US
dc.contributor.authorHou, Yen_US
dc.contributor.authorCui, Cen_US
dc.contributor.authorKlein, WLen_US
dc.contributor.authorLuo, Yen_US
dc.date.accessioned2013-09-03T04:10:38Z-
dc.date.available2013-09-03T04:10:38Z-
dc.date.issued2009en_US
dc.identifier.citationJournal Of Alzheimer's Disease, 2009, v. 18 n. 4, p. 787-798en_US
dc.identifier.issn1387-2877en_US
dc.identifier.urihttp://hdl.handle.net/10722/188615-
dc.description.abstractLoss of synapses has been correlated with dementia in Alzheimer's disease (AD) as an early event during the disease progression. Hence, synaptogenesis and neurogenesis in adulthood could serve as a therapeutic target for the prevention and treatment of AD. Recently, we have demonstrated enhanced hippocampal neurogenesis by oral administration of Ginkgo biloba extract (EGb 761) to a mouse model of AD. This study aims to identify the constituents that contribute to EGb 761-induced neurogenesis. Among the constituents tested, bilobalide and quercetin significantly increased cell proliferation in the hippocampal neurons in a dose-dependent manner. Bilobalide and quercetin also enhanced phosphorylation of cyclic-AMP Response Element Binding Protein (CREB) in these cells, and elevated the levels of pCREB and, brain-derived neurotrophic factor in mice brain. Immunofluorescence staining of synaptic markers shows remarkable dendritic processes in hippocampal neurons treated with either quercetin or bilobalide. Furthermore, both constituents restored amyloid-β oligomers (also known as ADDL)-induced synaptic loss and phosphorylation of CREB. The present findings suggest that enhanced neurogenesis and synaptogenesis by bilobalide and quercetin may share a common final signaling pathway mediated by phosphorylation of CREB. Despite a recent report showing that EGb 761 was insufficient in prevent dementia, its constituents still warrant future investigation. © 2009-IOS Press and the authors. All rights reserved.en_US
dc.languageengen_US
dc.publisherIOS Press. The Journal's web site is located at http://www.iospress.nl/html/13872877.phpen_US
dc.relation.ispartofJournal of Alzheimer's Diseaseen_US
dc.subject.meshAlzheimer Disease - Drug Therapy - Metabolism - Physiopathologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlotting, Westernen_US
dc.subject.meshCyclic Amp Response Element-Binding Protein - Drug Effects - Metabolismen_US
dc.subject.meshCyclopentanes - Pharmacologyen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshFurans - Pharmacologyen_US
dc.subject.meshGinkgolides - Pharmacologyen_US
dc.subject.meshHippocampus - Drug Effects - Metabolismen_US
dc.subject.meshMiceen_US
dc.subject.meshNeurogenesis - Drug Effectsen_US
dc.subject.meshPhosphorylationen_US
dc.subject.meshPlant Extracts - Pharmacologyen_US
dc.subject.meshQuercetin - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSynapses - Drug Effectsen_US
dc.titleStimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neuronsen_US
dc.typeArticleen_US
dc.identifier.emailLao, L: lxlao1@hku.hken_US
dc.identifier.authorityLao, L=rp01784en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.3233/JAD-2009-1189en_US
dc.identifier.pmid19661619-
dc.identifier.scopuseid_2-s2.0-74949110261en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-74949110261&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume18en_US
dc.identifier.issue4en_US
dc.identifier.spage787en_US
dc.identifier.epage798en_US
dc.identifier.isiWOS:000272863500005-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridTchantchou, F=6506692750en_US
dc.identifier.scopusauthoridLacor, PN=7004574259en_US
dc.identifier.scopusauthoridCao, Z=8741147700en_US
dc.identifier.scopusauthoridLao, L=7005681883en_US
dc.identifier.scopusauthoridHou, Y=36716080300en_US
dc.identifier.scopusauthoridCui, C=7201920204en_US
dc.identifier.scopusauthoridKlein, WL=7402435293en_US
dc.identifier.scopusauthoridLuo, Y=55712616300en_US

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