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Article: Magnolol and honokiol account for the anti-spasmodic effect of Magnolia officinalis in isolated guinea pig ileum

TitleMagnolol and honokiol account for the anti-spasmodic effect of Magnolia officinalis in isolated guinea pig ileum
Authors
Issue Date2008
PublisherGeorg Thieme Verlag. The Journal's web site is located at http://www.thieme.de/plantamedica/index.html
Citation
Planta Medica, 2008, v. 74 n. 4, p. 381-384 How to Cite?
AbstractMagnolia officinalis is a commonly used traditional Chinese medicine for treating gastrointestinal disorders. HPLC quantification analysis revealed that magnolol and honokiol were the most abundant constituents of M. officinalis extracts, with their contents in the ethanol extract being the highest, the water extract the least and the 50% ethanol extract in between. In guinea pig isolated ileum, both magnolol and honokiol inhibited contraction to acetylcholine. The herbal extracts also produced inhibitory responses, in an order of decreasing efficacy: ethanol extract > 50% ethanol extract > water extract. The differences in inhibitory efficacies among the three extracts were similar to the differences in their magnolol and honokiol contents. Further examination demonstrated that two mixtures containing solely magnolol and honokiol at concentrations identical to those determined in the ethanol and water extracts exhibited similar levels of anti-spasmodic effects as their respective extracts while a "blank" ethanol extract free of magnolol and honokiol failed to produce any response. These observations suggest that the magnolol and honokiol contents account for the anti-spasmodic effects of M. officinalis extracts in guinea pig isolated ileum. © Georg Thieme Verlag KG Stuttgart.
Persistent Identifierhttp://hdl.handle.net/10722/188598
ISSN
2015 Impact Factor: 1.99
2015 SCImago Journal Rankings: 0.702
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, SSKen_US
dc.contributor.authorZhao, Men_US
dc.contributor.authorLao, Len_US
dc.contributor.authorFong, HHSen_US
dc.contributor.authorChe, CTen_US
dc.date.accessioned2013-09-03T04:10:31Z-
dc.date.available2013-09-03T04:10:31Z-
dc.date.issued2008en_US
dc.identifier.citationPlanta Medica, 2008, v. 74 n. 4, p. 381-384en_US
dc.identifier.issn0032-0943en_US
dc.identifier.urihttp://hdl.handle.net/10722/188598-
dc.description.abstractMagnolia officinalis is a commonly used traditional Chinese medicine for treating gastrointestinal disorders. HPLC quantification analysis revealed that magnolol and honokiol were the most abundant constituents of M. officinalis extracts, with their contents in the ethanol extract being the highest, the water extract the least and the 50% ethanol extract in between. In guinea pig isolated ileum, both magnolol and honokiol inhibited contraction to acetylcholine. The herbal extracts also produced inhibitory responses, in an order of decreasing efficacy: ethanol extract > 50% ethanol extract > water extract. The differences in inhibitory efficacies among the three extracts were similar to the differences in their magnolol and honokiol contents. Further examination demonstrated that two mixtures containing solely magnolol and honokiol at concentrations identical to those determined in the ethanol and water extracts exhibited similar levels of anti-spasmodic effects as their respective extracts while a "blank" ethanol extract free of magnolol and honokiol failed to produce any response. These observations suggest that the magnolol and honokiol contents account for the anti-spasmodic effects of M. officinalis extracts in guinea pig isolated ileum. © Georg Thieme Verlag KG Stuttgart.en_US
dc.languageengen_US
dc.publisherGeorg Thieme Verlag. The Journal's web site is located at http://www.thieme.de/plantamedica/index.htmlen_US
dc.relation.ispartofPlanta Medicaen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBiphenyl Compounds - Chemistry - Pharmacologyen_US
dc.subject.meshGuinea Pigsen_US
dc.subject.meshIleum - Drug Effectsen_US
dc.subject.meshLignans - Chemistry - Pharmacologyen_US
dc.subject.meshMagnolia - Chemistryen_US
dc.subject.meshMolecular Structureen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth - Drug Effectsen_US
dc.subject.meshPlant Extracts - Chemistry - Pharmacologyen_US
dc.titleMagnolol and honokiol account for the anti-spasmodic effect of Magnolia officinalis in isolated guinea pig ileumen_US
dc.typeArticleen_US
dc.identifier.emailLao, L: lxlao1@hku.hken_US
dc.identifier.authorityLao, L=rp01784en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1055/s-2008-1034320en_US
dc.identifier.pmid18484527-
dc.identifier.scopuseid_2-s2.0-42549088040en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-42549088040&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume74en_US
dc.identifier.issue4en_US
dc.identifier.spage381en_US
dc.identifier.epage384en_US
dc.identifier.isiWOS:000255365500002-
dc.publisher.placeGermanyen_US
dc.identifier.scopusauthoridChan, SSK=26031968400en_US
dc.identifier.scopusauthoridZhao, M=7403535102en_US
dc.identifier.scopusauthoridLao, L=7005681883en_US
dc.identifier.scopusauthoridFong, HHS=34569199300en_US
dc.identifier.scopusauthoridChe, CT=7102442768en_US

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