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Article: Involvement of opioid receptors in electroacupuncture-produced anti-hyperalgesia in rats with peripheral inflammation

TitleInvolvement of opioid receptors in electroacupuncture-produced anti-hyperalgesia in rats with peripheral inflammation
Authors
Issue Date2004
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 2004, v. 1020 n. 1-2, p. 12-17 How to Cite?
AbstractOur previous study showed that electroacupuncture (EA) significantly attenuated inflammatory hyperalgesia. It has also been reported that EA analgesia in uninjured animals is mediated by μ and δ opioid receptors at 2-15 Hz and by κ opioid receptor at 100 Hz. Because persistent pain changes neural response to external stimulation, we hypothesized that (1) the mechanisms of EA anti-hyperalgesia may be different under conditions of persistent pain and that (2) combining EA with a sub-effective dose of morphine could enhance EA anti-hyperalgesia. Hyperalgesia, decreased paw withdrawal latency (PWL) to a noxious thermal stimulus, was induced by subcutaneously injecting complete Freund's adjuvant (CFA) into the hind paws of rats. Selective antagonists against μ (D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-ThrNH2, CTOP), δ (naltrinodole, NTI) and κ (nor-binaltorphimine, BNI) opioid receptors were administered intrathecally 10 min before each of two EA treatments at acupoint Huantiao (GB30), one immediately post and the other 2 h post-CFA. Morphine was given (i.p.) 40 min before the second EA treatment. PWL was measured before and 2.5 and 5 h post-CFA. Both 10 and 100 Hz EA-produced anti-hyperalgesia were blocked spinally by μ- and δ- but not κ-receptor antagonists. EA combined with a sub-threshold dose of morphine (2.5 mg/kg) enhanced anti-hyperalgesia additively (10 Hz EA) or synergistically (100 Hz EA) compared to that produced by each component alone. These results suggest selective involvement of μ and δ, but not κ, receptors in EA-produced anti-hyperalgesia in rats. A combined EA and opioid drug protocol may provide an improved treatment strategy for inflammatory pain. © 2004 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/188596
ISSN
2015 Impact Factor: 2.561
2015 SCImago Journal Rankings: 1.351
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, RXen_US
dc.contributor.authorLao, Len_US
dc.contributor.authorWang, Len_US
dc.contributor.authorLiu, Ben_US
dc.contributor.authorWang, Xen_US
dc.contributor.authorRen, Ken_US
dc.contributor.authorBerman, BMen_US
dc.date.accessioned2013-09-03T04:10:30Z-
dc.date.available2013-09-03T04:10:30Z-
dc.date.issued2004en_US
dc.identifier.citationBrain Research, 2004, v. 1020 n. 1-2, p. 12-17en_US
dc.identifier.issn0006-8993en_US
dc.identifier.urihttp://hdl.handle.net/10722/188596-
dc.description.abstractOur previous study showed that electroacupuncture (EA) significantly attenuated inflammatory hyperalgesia. It has also been reported that EA analgesia in uninjured animals is mediated by μ and δ opioid receptors at 2-15 Hz and by κ opioid receptor at 100 Hz. Because persistent pain changes neural response to external stimulation, we hypothesized that (1) the mechanisms of EA anti-hyperalgesia may be different under conditions of persistent pain and that (2) combining EA with a sub-effective dose of morphine could enhance EA anti-hyperalgesia. Hyperalgesia, decreased paw withdrawal latency (PWL) to a noxious thermal stimulus, was induced by subcutaneously injecting complete Freund's adjuvant (CFA) into the hind paws of rats. Selective antagonists against μ (D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-ThrNH2, CTOP), δ (naltrinodole, NTI) and κ (nor-binaltorphimine, BNI) opioid receptors were administered intrathecally 10 min before each of two EA treatments at acupoint Huantiao (GB30), one immediately post and the other 2 h post-CFA. Morphine was given (i.p.) 40 min before the second EA treatment. PWL was measured before and 2.5 and 5 h post-CFA. Both 10 and 100 Hz EA-produced anti-hyperalgesia were blocked spinally by μ- and δ- but not κ-receptor antagonists. EA combined with a sub-threshold dose of morphine (2.5 mg/kg) enhanced anti-hyperalgesia additively (10 Hz EA) or synergistically (100 Hz EA) compared to that produced by each component alone. These results suggest selective involvement of μ and δ, but not κ, receptors in EA-produced anti-hyperalgesia in rats. A combined EA and opioid drug protocol may provide an improved treatment strategy for inflammatory pain. © 2004 Elsevier B.V. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresen_US
dc.relation.ispartofBrain Researchen_US
dc.subject.meshAnalgesics, Opioid - Pharmacologyen_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshCombined Modality Therapyen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshElectroacupunctureen_US
dc.subject.meshHyperalgesia - Physiopathology - Therapyen_US
dc.subject.meshInflammation - Complications - Physiopathology - Therapyen_US
dc.subject.meshInjections, Spinalen_US
dc.subject.meshMaleen_US
dc.subject.meshMorphine - Pharmacologyen_US
dc.subject.meshNarcotic Antagonists - Administration & Dosageen_US
dc.subject.meshPain - Etiology - Physiopathologyen_US
dc.subject.meshPain Managementen_US
dc.subject.meshRandom Allocationen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshReaction Time - Drug Effectsen_US
dc.subject.meshReceptors, Opioid - Classification - Metabolismen_US
dc.titleInvolvement of opioid receptors in electroacupuncture-produced anti-hyperalgesia in rats with peripheral inflammationen_US
dc.typeArticleen_US
dc.identifier.emailLao, L: lxlao1@hku.hken_US
dc.identifier.authorityLao, L=rp01784en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.brainres.2004.05.067en_US
dc.identifier.pmid15312782en_US
dc.identifier.scopuseid_2-s2.0-4143095861en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-4143095861&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume1020en_US
dc.identifier.issue1-2en_US
dc.identifier.spage12en_US
dc.identifier.epage17en_US
dc.identifier.isiWOS:000223711200002-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridZhang, RX=7404864527en_US
dc.identifier.scopusauthoridLao, L=7005681883en_US
dc.identifier.scopusauthoridWang, L=9036448600en_US
dc.identifier.scopusauthoridLiu, B=55720712900en_US
dc.identifier.scopusauthoridWang, X=7501857339en_US
dc.identifier.scopusauthoridRen, K=7102272533en_US
dc.identifier.scopusauthoridBerman, BM=35458606800en_US

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