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Article: Electroacupuncture combined with indomethacin enhances antihyperalgesia in inflammatory rats

TitleElectroacupuncture combined with indomethacin enhances antihyperalgesia in inflammatory rats
Authors
Issue Date2004
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pharmbiochembeh
Citation
Pharmacology Biochemistry And Behavior, 2004, v. 78 n. 4, p. 793-797 How to Cite?
AbstractOur previous study showed that electroacupuncture (EA), an adjuvant to conventional medicine, significantly attenuated hyperalgesia and inflammation. The present study is an evaluation of the potential synergism of EA and a subeffective dosage of indomethacin (INDO) in a rat model. Inflammation and hyperalgesia, manifesting as edema and decreased paw withdrawal latency (PWL) to a noxious stimulus, were induced by injecting complete Freund's adjuvant (CFA) subcutaneously into the plantar surface of one hind paw of the rat. EA treatments were given at acupoint GB30 immediately and 2 h post-CFA. INDO at 2 mg/kg was given (intraperitoneally) 40 min before the second EA. PWL and edema were measured prior to CFA and 2.5 and 5 h post-CFA. Ten and 100 Hz EA significantly inhibited CFA-induced hind paw hyperalgesia. Both low- and high-frequency EA combined with INDO enhanced antihyperalgesia compared to each component alone, and 10 Hz but not 100 Hz EA significantly reduced CFA-induced hind paw edema. A combination of low-frequency EA and INDO did not show synergistic inhibitory effects on edema. The results demonstrate that EA combined with INDO synergistically inhibits hyperalgesia and suggest an improved treatment strategy for inflammatory pain. © 2004 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/188592
ISSN
2015 Impact Factor: 2.537
2015 SCImago Journal Rankings: 1.121
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, RXen_US
dc.contributor.authorLao, Len_US
dc.contributor.authorWang, Xen_US
dc.contributor.authorRen, Ken_US
dc.contributor.authorBerman, BBen_US
dc.date.accessioned2013-09-03T04:10:29Z-
dc.date.available2013-09-03T04:10:29Z-
dc.date.issued2004en_US
dc.identifier.citationPharmacology Biochemistry And Behavior, 2004, v. 78 n. 4, p. 793-797en_US
dc.identifier.issn0091-3057en_US
dc.identifier.urihttp://hdl.handle.net/10722/188592-
dc.description.abstractOur previous study showed that electroacupuncture (EA), an adjuvant to conventional medicine, significantly attenuated hyperalgesia and inflammation. The present study is an evaluation of the potential synergism of EA and a subeffective dosage of indomethacin (INDO) in a rat model. Inflammation and hyperalgesia, manifesting as edema and decreased paw withdrawal latency (PWL) to a noxious stimulus, were induced by injecting complete Freund's adjuvant (CFA) subcutaneously into the plantar surface of one hind paw of the rat. EA treatments were given at acupoint GB30 immediately and 2 h post-CFA. INDO at 2 mg/kg was given (intraperitoneally) 40 min before the second EA. PWL and edema were measured prior to CFA and 2.5 and 5 h post-CFA. Ten and 100 Hz EA significantly inhibited CFA-induced hind paw hyperalgesia. Both low- and high-frequency EA combined with INDO enhanced antihyperalgesia compared to each component alone, and 10 Hz but not 100 Hz EA significantly reduced CFA-induced hind paw edema. A combination of low-frequency EA and INDO did not show synergistic inhibitory effects on edema. The results demonstrate that EA combined with INDO synergistically inhibits hyperalgesia and suggest an improved treatment strategy for inflammatory pain. © 2004 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/pharmbiochembehen_US
dc.relation.ispartofPharmacology Biochemistry and Behavioren_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal - Pharmacologyen_US
dc.subject.meshEdema - Drug Therapyen_US
dc.subject.meshElectroacupunctureen_US
dc.subject.meshFreund's Adjuvanten_US
dc.subject.meshHot Temperatureen_US
dc.subject.meshHyperalgesia - Drug Therapy - Etiology - Therapyen_US
dc.subject.meshIndomethacin - Pharmacologyen_US
dc.subject.meshInflammation - Chemically Induced - Complicationsen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshReaction Time - Drug Effectsen_US
dc.titleElectroacupuncture combined with indomethacin enhances antihyperalgesia in inflammatory ratsen_US
dc.typeArticleen_US
dc.identifier.emailLao, L: lxlao1@hku.hken_US
dc.identifier.authorityLao, L=rp01784en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.pbb.2004.05.010en_US
dc.identifier.pmid15301937en_US
dc.identifier.scopuseid_2-s2.0-3843140635en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-3843140635&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume78en_US
dc.identifier.issue4en_US
dc.identifier.spage793en_US
dc.identifier.epage797en_US
dc.identifier.isiWOS:000223527200020-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridZhang, RX=7404864527en_US
dc.identifier.scopusauthoridLao, L=7005681883en_US
dc.identifier.scopusauthoridWang, X=7501857339en_US
dc.identifier.scopusauthoridRen, K=7102272533en_US
dc.identifier.scopusauthoridBerman, BB=35458606800en_US

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