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Article: A parametric study of electroacupuncture on persistent hyperalgesia and Fos protein expression in rats

TitleA parametric study of electroacupuncture on persistent hyperalgesia and Fos protein expression in rats
Authors
Issue Date2004
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 2004, v. 1020 n. 1-2, p. 18-29 How to Cite?
AbstractWe previously reported the anti-hyperalgesia of electroacupuncture (EA) on persistent inflammatory pain in an unrestrained, unsedated, and conscious rat model. Using this model, induced by injecting complete Freund's adjuvant (CFA) into one hind paw, we systematically evaluated the anti-hyperalgesia of EA stimulation parameters (frequency, intensity, treatment duration, and pulse width). We assessed hyperalgesia by paw withdrawal latency (PWL) to a noxious thermal stimulus and found that 10- and 100-Hz EA frequencies at a current intensity of 3 mA produced the greatest anti-hyperalgesia, when compared to other parameters. Both frequencies significantly increased PWL in the early phases of hyperalgesia (2.5 and 24 h; p<0.05), and 10 Hz EA also significantly increased PWL in later phases (5 to 7 days; p<0.05). A sufficient but tolerable intensity of 3 mA was more effective than lower intensities (1-2 mA). A 20-min treatment produced better anti-hyperalgesia than longer and shorter (10 and 30 min) treatments. Acupoint specificity study demonstrated that GB30 produced significant EA anti-hyperalgesia, while Waiguan (TE5) and sham points, an abdominal point and a point at the opposite aspect of GB30, did not. The spinal Fos protein expression study demonstrated that the optimal EA selectively suppressed Fos expression in superficial laminae (I/II) and activated it in deeper laminae (III/IV) of the spinal dorsal horn. The results suggest that the EA anti-hyperalgesia is parameter-dependent and point-specific, and they provide important information for designing further clinical acupuncture research on persistent inflammatory pain. © 2004 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/188591
ISSN
2015 Impact Factor: 2.561
2015 SCImago Journal Rankings: 1.351
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLao, Len_US
dc.contributor.authorZhang, RXen_US
dc.contributor.authorZhang, Gen_US
dc.contributor.authorWang, Xen_US
dc.contributor.authorBerman, BMen_US
dc.contributor.authorRen, Ken_US
dc.date.accessioned2013-09-03T04:10:28Z-
dc.date.available2013-09-03T04:10:28Z-
dc.date.issued2004en_US
dc.identifier.citationBrain Research, 2004, v. 1020 n. 1-2, p. 18-29en_US
dc.identifier.issn0006-8993en_US
dc.identifier.urihttp://hdl.handle.net/10722/188591-
dc.description.abstractWe previously reported the anti-hyperalgesia of electroacupuncture (EA) on persistent inflammatory pain in an unrestrained, unsedated, and conscious rat model. Using this model, induced by injecting complete Freund's adjuvant (CFA) into one hind paw, we systematically evaluated the anti-hyperalgesia of EA stimulation parameters (frequency, intensity, treatment duration, and pulse width). We assessed hyperalgesia by paw withdrawal latency (PWL) to a noxious thermal stimulus and found that 10- and 100-Hz EA frequencies at a current intensity of 3 mA produced the greatest anti-hyperalgesia, when compared to other parameters. Both frequencies significantly increased PWL in the early phases of hyperalgesia (2.5 and 24 h; p<0.05), and 10 Hz EA also significantly increased PWL in later phases (5 to 7 days; p<0.05). A sufficient but tolerable intensity of 3 mA was more effective than lower intensities (1-2 mA). A 20-min treatment produced better anti-hyperalgesia than longer and shorter (10 and 30 min) treatments. Acupoint specificity study demonstrated that GB30 produced significant EA anti-hyperalgesia, while Waiguan (TE5) and sham points, an abdominal point and a point at the opposite aspect of GB30, did not. The spinal Fos protein expression study demonstrated that the optimal EA selectively suppressed Fos expression in superficial laminae (I/II) and activated it in deeper laminae (III/IV) of the spinal dorsal horn. The results suggest that the EA anti-hyperalgesia is parameter-dependent and point-specific, and they provide important information for designing further clinical acupuncture research on persistent inflammatory pain. © 2004 Elsevier B.V. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresen_US
dc.relation.ispartofBrain Researchen_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshElectroacupuncture - Methodsen_US
dc.subject.meshHyperalgesia - Therapyen_US
dc.subject.meshInflammation - Complications - Physiopathology - Therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshNeurons - Metabolismen_US
dc.subject.meshPain - Etiology - Physiopathologyen_US
dc.subject.meshPain Managementen_US
dc.subject.meshProto-Oncogene Proteins C-Fos - Metabolismen_US
dc.subject.meshRandom Allocationen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshReaction Time - Physiologyen_US
dc.subject.meshSpinal Cord - Cytology - Metabolismen_US
dc.titleA parametric study of electroacupuncture on persistent hyperalgesia and Fos protein expression in ratsen_US
dc.typeArticleen_US
dc.identifier.emailLao, L: lxlao1@hku.hken_US
dc.identifier.authorityLao, L=rp01784en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.brainres.2004.01.092en_US
dc.identifier.pmid15312783-
dc.identifier.scopuseid_2-s2.0-3843118363en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-3843118363&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume1020en_US
dc.identifier.issue1-2en_US
dc.identifier.spage18en_US
dc.identifier.epage29en_US
dc.identifier.isiWOS:000223711200003-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridLao, L=7005681883en_US
dc.identifier.scopusauthoridZhang, RX=7404864527en_US
dc.identifier.scopusauthoridZhang, G=7405272323en_US
dc.identifier.scopusauthoridWang, X=7501857339en_US
dc.identifier.scopusauthoridBerman, BM=35458606800en_US
dc.identifier.scopusauthoridRen, K=7102272533en_US

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