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Article: Involvement of Peripheral Opioid Mechanisms in Electroacupuncture Analgesia

TitleInvolvement of Peripheral Opioid Mechanisms in Electroacupuncture Analgesia
Authors
Issue Date2005
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/explore
Citation
Explore: The Journal Of Science And Healing, 2005, v. 1 n. 5, p. 365-371 How to Cite?
AbstractThe involvement of the peripheral opioid system in modulating inflammatory pain has been well documented. This study aimed to investigate the possibility of electroacupuncture (EA)-mediated peripheral opioid release. Rats were injected with complete Freund's adjuvant in one of the hind paws to induce localized inflammatory pain. The pain behavioral changes were measured by paw withdrawal latency (PWL) to a noxious thermal stimulus. At day 5 of inflammation, rats received a second injection of saline or opioid antagonists into the inflamed paw, followed by EA at 30 Hz, 2 mA, and 0.1 ms for 30 minutes. The EA was conducted at acupuncture point GB30. A control was used in which needles were inserted at GB30 but no electrical stimulation was applied. Rats receiving EA showed a significantly longer PWL as compared with the control from 30 minutes to three hours after EA treatment. Intraplantar but not intraperitoneal injection of naloxone methiodide, a peripherally acting opioid receptor antagonist, eliminated the analgesic effect at 30 minutes after EA treatment. Intraplantar injection of an antibody against β-endorphin and a corticotropin-releasing factor antagonist also produced a reduction in PWL in rats receiving EA. These data strongly suggest that peripheral opioids are released by EA at the inflammatory site. © 2005 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/188581
ISSN
2015 Impact Factor: 1.012
2015 SCImago Journal Rankings: 0.252
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, GGen_US
dc.contributor.authorYu, Cen_US
dc.contributor.authorLee, Wen_US
dc.contributor.authorLao, Len_US
dc.contributor.authorRen, Ken_US
dc.contributor.authorBerman, BMen_US
dc.date.accessioned2013-09-03T04:10:26Z-
dc.date.available2013-09-03T04:10:26Z-
dc.date.issued2005en_US
dc.identifier.citationExplore: The Journal Of Science And Healing, 2005, v. 1 n. 5, p. 365-371en_US
dc.identifier.issn1550-8307en_US
dc.identifier.urihttp://hdl.handle.net/10722/188581-
dc.description.abstractThe involvement of the peripheral opioid system in modulating inflammatory pain has been well documented. This study aimed to investigate the possibility of electroacupuncture (EA)-mediated peripheral opioid release. Rats were injected with complete Freund's adjuvant in one of the hind paws to induce localized inflammatory pain. The pain behavioral changes were measured by paw withdrawal latency (PWL) to a noxious thermal stimulus. At day 5 of inflammation, rats received a second injection of saline or opioid antagonists into the inflamed paw, followed by EA at 30 Hz, 2 mA, and 0.1 ms for 30 minutes. The EA was conducted at acupuncture point GB30. A control was used in which needles were inserted at GB30 but no electrical stimulation was applied. Rats receiving EA showed a significantly longer PWL as compared with the control from 30 minutes to three hours after EA treatment. Intraplantar but not intraperitoneal injection of naloxone methiodide, a peripherally acting opioid receptor antagonist, eliminated the analgesic effect at 30 minutes after EA treatment. Intraplantar injection of an antibody against β-endorphin and a corticotropin-releasing factor antagonist also produced a reduction in PWL in rats receiving EA. These data strongly suggest that peripheral opioids are released by EA at the inflammatory site. © 2005 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/exploreen_US
dc.relation.ispartofExplore: The Journal of Science and Healingen_US
dc.subject.meshAcupuncture Analgesia - Methodsen_US
dc.subject.meshAcupuncture Pointsen_US
dc.subject.meshAnalgesics, Opioid - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshElectroacupuncture - Methodsen_US
dc.subject.meshFreund's Adjuvant - Pharmacologyen_US
dc.subject.meshHyperalgesia - Therapyen_US
dc.subject.meshInflammation - Chemically Induced - Physiopathology - Therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshPain - Prevention & Controlen_US
dc.subject.meshPain Measurementen_US
dc.subject.meshRandom Allocationen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshReaction Time - Drug Effectsen_US
dc.subject.meshTranscutaneous Electric Nerve Stimulation - Methodsen_US
dc.titleInvolvement of Peripheral Opioid Mechanisms in Electroacupuncture Analgesiaen_US
dc.typeArticleen_US
dc.identifier.emailLao, L: lxlao1@hku.hken_US
dc.identifier.authorityLao, L=rp01784en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.explore.2005.06.006en_US
dc.identifier.pmid16781567-
dc.identifier.scopuseid_2-s2.0-33745498034en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33745498034&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume1en_US
dc.identifier.issue5en_US
dc.identifier.spage365en_US
dc.identifier.epage371en_US
dc.identifier.isiWOS:000202962700009-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridZhang, GG=7405272323en_US
dc.identifier.scopusauthoridYu, C=7404978366en_US
dc.identifier.scopusauthoridLee, W=7407085578en_US
dc.identifier.scopusauthoridLao, L=7005681883en_US
dc.identifier.scopusauthoridRen, K=7102272533en_US
dc.identifier.scopusauthoridBerman, BM=35458606800en_US

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