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Article: Effects of total glycosides from Baishouwu on human breast and prostate cancer cell proliferation

TitleEffects of total glycosides from Baishouwu on human breast and prostate cancer cell proliferation
Authors
Issue Date2003
PublisherInnoVision Communications. The Journal's web site is located at www.alternative-therapies.com
Citation
Alternative Therapies In Health And Medicine, 2003, v. 9 n. 5, p. 62-66 How to Cite?
AbstractBaishouwu (Cynanchum Auriculalum Royle ex Wight), a traditional Chinese herbal medicine, is used as a traditional anti-aging remedy in China. Previous studies suggested Baishouwu has multiple pharmacological actions. In this study, the total glycosides extracted from Baishouwu (CA/TG) were evaluated for its potential anti-tumor activity and mechanism on several human breast and prostate cancer cell lines. In [ 3H] thymidine incorporation assay, CA/TG inhibited the proliferation of cancer cells in a dose-dependent fashion. It also displayed anti-androgen activity on androgen sensitive cell line assessed by reporter gene assay. The morphological examination of CA/TG treated cells revealed overall shrinkage of nucleus, chromatin condensation and small nuclear fragments by DAPI staining, the characteristic pattern of DNA ladders were observed in cells exposed to CA/TG, indicating the involvement of apoptosis in its action. These results suggested that the CA/TG has preferred cytotoxicity against the cancer cells, and the action was due to its ability of preventing cell proliferation and inducing apoptosis.
Persistent Identifierhttp://hdl.handle.net/10722/188552
ISSN
2015 Impact Factor: 1.329
2015 SCImago Journal Rankings: 0.497
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Hen_US
dc.contributor.authorWang, Qen_US
dc.contributor.authorSrivastava, RKen_US
dc.contributor.authorGong, SSen_US
dc.contributor.authorLao, Len_US
dc.contributor.authorFondell, JDen_US
dc.contributor.authorWang, JBen_US
dc.date.accessioned2013-09-03T04:10:14Z-
dc.date.available2013-09-03T04:10:14Z-
dc.date.issued2003en_US
dc.identifier.citationAlternative Therapies In Health And Medicine, 2003, v. 9 n. 5, p. 62-66en_US
dc.identifier.issn1078-6791en_US
dc.identifier.urihttp://hdl.handle.net/10722/188552-
dc.description.abstractBaishouwu (Cynanchum Auriculalum Royle ex Wight), a traditional Chinese herbal medicine, is used as a traditional anti-aging remedy in China. Previous studies suggested Baishouwu has multiple pharmacological actions. In this study, the total glycosides extracted from Baishouwu (CA/TG) were evaluated for its potential anti-tumor activity and mechanism on several human breast and prostate cancer cell lines. In [ 3H] thymidine incorporation assay, CA/TG inhibited the proliferation of cancer cells in a dose-dependent fashion. It also displayed anti-androgen activity on androgen sensitive cell line assessed by reporter gene assay. The morphological examination of CA/TG treated cells revealed overall shrinkage of nucleus, chromatin condensation and small nuclear fragments by DAPI staining, the characteristic pattern of DNA ladders were observed in cells exposed to CA/TG, indicating the involvement of apoptosis in its action. These results suggested that the CA/TG has preferred cytotoxicity against the cancer cells, and the action was due to its ability of preventing cell proliferation and inducing apoptosis.en_US
dc.languageengen_US
dc.publisherInnoVision Communications. The Journal's web site is located at www.alternative-therapies.comen_US
dc.relation.ispartofAlternative Therapies in Health and Medicineen_US
dc.subject.meshAntineoplastic Agents, Phytogenic - Pharmacologyen_US
dc.subject.meshApoptosis - Drug Effectsen_US
dc.subject.meshBenzophenones - Pharmacologyen_US
dc.subject.meshBreast Neoplasms - Drug Therapy - Pathologyen_US
dc.subject.meshCell Division - Drug Effectsen_US
dc.subject.meshDna Fragmentation - Drug Effectsen_US
dc.subject.meshDna, Neoplasm - Drug Effectsen_US
dc.subject.meshDrugs, Chinese Herbal - Pharmacologyen_US
dc.subject.meshElectrophoresis, Agar Gelen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshProstatic Neoplasms - Drug Therapy - Pathologyen_US
dc.subject.meshThymidine - Diagnostic Useen_US
dc.subject.meshTumor Cells, Cultureden_US
dc.titleEffects of total glycosides from Baishouwu on human breast and prostate cancer cell proliferationen_US
dc.typeArticleen_US
dc.identifier.emailLao, L: lxlao1@hku.hken_US
dc.identifier.authorityLao, L=rp01784en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid14526712-
dc.identifier.scopuseid_2-s2.0-0141708045en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0141708045&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume9en_US
dc.identifier.issue5en_US
dc.identifier.spage62en_US
dc.identifier.epage66en_US
dc.identifier.isiWOS:000185291900009-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWang, H=36065838600en_US
dc.identifier.scopusauthoridWang, Q=8694228900en_US
dc.identifier.scopusauthoridSrivastava, RK=7401869520en_US
dc.identifier.scopusauthoridGong, SS=35339046800en_US
dc.identifier.scopusauthoridLao, L=7005681883en_US
dc.identifier.scopusauthoridFondell, JD=6603965124en_US
dc.identifier.scopusauthoridWang, JB=7701331009en_US

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