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Conference Paper: Green tea supplementation during gestation and lactation modulates heart lipid metabolism and oxidative status in rat offspring born of high-fat diet-fed dams

TitleGreen tea supplementation during gestation and lactation modulates heart lipid metabolism and oxidative status in rat offspring born of high-fat diet-fed dams
Authors
KeywordsBiology
Issue Date2012
PublisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/
Citation
Experimental Biology 2012, San Diego, CA., 21-25 April 2012. In The FASEB Journal, 2012, v. 26 meeting abstracts, no. 648.3 How to Cite?
AbstractHepatic glucose and lipid metabolism, and insulin sensitivity of offspring born to high-fat (HF) diet fed dams could be improved by supplementing green tea extract (GTE) to the dam’s diet either during gestation or lactation. This study further examined the effects of developmental programming on lipid metabolism and oxidative status in the heart. Dams were fed low-fat (LF), HF, or HF with 0.75% GTE (GT) throughout gestation. During lactation, half of the HF dams were given the GT diet and vice versa. All pups were fed with LF or HF diet for 16 wk. 3-way ANOVA was used to analyze for diet effect in gestation, lactation and postweaning periods. GTE effects were more prominent during lactation than gestation. Heart triglyceride, cholesterol and free fatty acid levels were higher (P < 0.01) in offspring of dams fed GT compared with those fed HF diet during lactation. The former group also had up-regulated mRNA expression of proliferators – activated receptor alpha and its downstream genes (P < 0.05). Concurrently, activities of catalase, glutathione peroxidase and glutathione transferase in the heart were elevated (P < 0.05). The data suggested that with increase in lipid utilization (anabolic and catabolic), the heart of offspring born of GT dams is protected by improved oxidative status. Developmental programming triggered by maternal GTE supplementation appears to be time and organ specific.
Persistent Identifierhttp://hdl.handle.net/10722/188015
ISSN
2015 Impact Factor: 5.299
2015 SCImago Journal Rankings: 2.775

 

DC FieldValueLanguage
dc.contributor.authorLam, CYen_US
dc.contributor.authorLi, ETSen_US
dc.date.accessioned2013-08-21T07:24:52Z-
dc.date.available2013-08-21T07:24:52Z-
dc.date.issued2012en_US
dc.identifier.citationExperimental Biology 2012, San Diego, CA., 21-25 April 2012. In The FASEB Journal, 2012, v. 26 meeting abstracts, no. 648.3en_US
dc.identifier.issn0892-6638-
dc.identifier.urihttp://hdl.handle.net/10722/188015-
dc.description.abstractHepatic glucose and lipid metabolism, and insulin sensitivity of offspring born to high-fat (HF) diet fed dams could be improved by supplementing green tea extract (GTE) to the dam’s diet either during gestation or lactation. This study further examined the effects of developmental programming on lipid metabolism and oxidative status in the heart. Dams were fed low-fat (LF), HF, or HF with 0.75% GTE (GT) throughout gestation. During lactation, half of the HF dams were given the GT diet and vice versa. All pups were fed with LF or HF diet for 16 wk. 3-way ANOVA was used to analyze for diet effect in gestation, lactation and postweaning periods. GTE effects were more prominent during lactation than gestation. Heart triglyceride, cholesterol and free fatty acid levels were higher (P < 0.01) in offspring of dams fed GT compared with those fed HF diet during lactation. The former group also had up-regulated mRNA expression of proliferators – activated receptor alpha and its downstream genes (P < 0.05). Concurrently, activities of catalase, glutathione peroxidase and glutathione transferase in the heart were elevated (P < 0.05). The data suggested that with increase in lipid utilization (anabolic and catabolic), the heart of offspring born of GT dams is protected by improved oxidative status. Developmental programming triggered by maternal GTE supplementation appears to be time and organ specific.-
dc.languageengen_US
dc.publisherFederation of American Societies for Experimental Biology. The Journal's web site is located at http://www.fasebj.org/-
dc.relation.ispartofThe FASEB Journalen_US
dc.subjectBiology-
dc.titleGreen tea supplementation during gestation and lactation modulates heart lipid metabolism and oxidative status in rat offspring born of high-fat diet-fed damsen_US
dc.typeConference_Paperen_US
dc.identifier.emailLi, ETS: etsli@hku.hken_US
dc.identifier.authorityLi, ETS=rp00737en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros220269en_US
dc.identifier.volume26-
dc.identifier.issuemeeting abstracts-
dc.publisher.placeUnited States-

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