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Conference Paper: Developmental toxicity of one marine dinoflagellate toxicant-saxitoxin

TitleDevelopmental toxicity of one marine dinoflagellate toxicant-saxitoxin
Authors
Issue Date2013
PublisherGeorg Thieme Verlag. The Journal's web site is located at http://www.thieme.de/plantamedica/index.html
Citation
The 8th Joint Meeting of AFERP, ASP, GA, PSE and SIF, New York, NY., 1 August 2012. In Planta Medica, 2012, n. 11, v. 78, abstract PI9 How to Cite?
AbstractSaxitoxin (STX), found mainly in marine dinoflagellates, is one water-soluble neurotoxin. When some fishes accumulate STX and are consumed by humans, it would cause a series of diseases, especially to children. STX was known to possess high binding affinity to the soluble sites of sodium channels and interrupts the propagation of neuronal impulses by blocking the sodium channel in excitable cells, however, it still remain unknown whether STX can contribute to other toxic effects or not. In our current study, we adopted medaka fish (Oryzias melastigma) embryos as model animals to study its developmental toxicity to children. By detecting the protein markers using 2-D electrophoresis combined with MALDI TOF/TOF MS, we found that STX could accelerate the embryonic development by enhancing the expression of stress related proteins and metabolism proteins, and by regulating phosphorylation processes.
DescriptionThis journal issue entitled: 8th Joint Meeting of AFERP, ASP, GA, PSE and SIF ... 2012. The abstracts' web site is located at https://www.thieme-connect.de/ejournals/issue/10.1055/s-002-23510/grouping/020261/10.1055/s-00000058
Poster - Topic I: Natural Products Discovery: Marine, Microbes, Plants and other: abstract PI9
Persistent Identifierhttp://hdl.handle.net/10722/188009
ISSN
2015 Impact Factor: 1.99
2015 SCImago Journal Rankings: 0.702

 

DC FieldValueLanguage
dc.contributor.authorTian, Len_US
dc.contributor.authorWang, M-
dc.date.accessioned2013-08-21T07:24:48Z-
dc.date.available2013-08-21T07:24:48Z-
dc.date.issued2013en_US
dc.identifier.citationThe 8th Joint Meeting of AFERP, ASP, GA, PSE and SIF, New York, NY., 1 August 2012. In Planta Medica, 2012, n. 11, v. 78, abstract PI9en_US
dc.identifier.issn0032-0943-
dc.identifier.urihttp://hdl.handle.net/10722/188009-
dc.descriptionThis journal issue entitled: 8th Joint Meeting of AFERP, ASP, GA, PSE and SIF ... 2012. The abstracts' web site is located at https://www.thieme-connect.de/ejournals/issue/10.1055/s-002-23510/grouping/020261/10.1055/s-00000058-
dc.descriptionPoster - Topic I: Natural Products Discovery: Marine, Microbes, Plants and other: abstract PI9-
dc.description.abstractSaxitoxin (STX), found mainly in marine dinoflagellates, is one water-soluble neurotoxin. When some fishes accumulate STX and are consumed by humans, it would cause a series of diseases, especially to children. STX was known to possess high binding affinity to the soluble sites of sodium channels and interrupts the propagation of neuronal impulses by blocking the sodium channel in excitable cells, however, it still remain unknown whether STX can contribute to other toxic effects or not. In our current study, we adopted medaka fish (Oryzias melastigma) embryos as model animals to study its developmental toxicity to children. By detecting the protein markers using 2-D electrophoresis combined with MALDI TOF/TOF MS, we found that STX could accelerate the embryonic development by enhancing the expression of stress related proteins and metabolism proteins, and by regulating phosphorylation processes.-
dc.languageengen_US
dc.publisherGeorg Thieme Verlag. The Journal's web site is located at http://www.thieme.de/plantamedica/index.html-
dc.relation.ispartofPlanta Medicaen_US
dc.rightsPlanta Medica. Copyright © Georg Thieme Verlag.-
dc.titleDevelopmental toxicity of one marine dinoflagellate toxicant-saxitoxinen_US
dc.typeConference_Paperen_US
dc.identifier.emailWang, M: mfwang@hku.hk-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1055/s-0032-1320696-
dc.identifier.hkuros219649en_US
dc.identifier.volume78-
dc.identifier.issue11-
dc.publisher.placeGermanyen_US
dc.customcontrol.immutablesml 130911-

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