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Article: Lycium Barbarum (wolfberry) reduces secondary degeneration and oxidative stress, and inhibits JNK pathway in retina after partial optic nerve transection

TitleLycium Barbarum (wolfberry) reduces secondary degeneration and oxidative stress, and inhibits JNK pathway in retina after partial optic nerve transection
Authors
Issue Date2013
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
PLoS One, 2013, v. 8 n. 7, article no. e68881, p. 1-13 How to Cite?
AbstractOur group has shown that the polysaccharides extracted from Lycium barbarum (LBP) are neuroprotective for retinal ganglion cells (RGCs) in different animal models. Protecting RGCs from secondary degeneration is a promising direction for therapy in glaucoma management. The complete optic nerve transection (CONT) model can be used to study primary degeneration of RGCs, while the partial optic nerve transection (PONT) model can be used to study secondary degeneration of RGCs because primary degeneration of RGCs and secondary degeneration can be separated in location in the same retina in this model; in other situations, these types of degeneration can be difficult to distinguish. In order to examine which kind of degeneration LBP could delay, both CONT and PONT models were used in this study. Rats were fed with LBP or vehicle daily from 7 days before surgery until sacrifice at different time-points and the surviving numbers of RGCs were evaluated. The expression of several proteins related to inflammation, oxidative stress, and the c-jun N-terminal kinase (JNK) pathways were detected with Western-blot analysis. LBP did not delay primary degeneration of RGCs after either CONT or PONT, but it did delay secondary degeneration of RGCs after PONT. We found that LBP appeared to exert these protective effects by inhibiting oxidative stress and the JNK/c-jun pathway and by transiently increasing production of insulin-like growth factor-1 (IGF-1). This study suggests that LBP can delay secondary degeneration of RGCs and this effect may be linked to inhibition of oxidative stress and the JNK/c-jun pathway in the retina. © 2013 Li et al.
Persistent Identifierhttp://hdl.handle.net/10722/187502
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Hen_US
dc.contributor.authorLiang, Yen_US
dc.contributor.authorChiu, Ken_US
dc.contributor.authorYuan, Qen_US
dc.contributor.authorLin, Ben_US
dc.contributor.authorChang, RCCen_US
dc.contributor.authorSo, KFen_US
dc.date.accessioned2013-08-20T12:56:27Z-
dc.date.available2013-08-20T12:56:27Z-
dc.date.issued2013en_US
dc.identifier.citationPLoS One, 2013, v. 8 n. 7, article no. e68881, p. 1-13en_US
dc.identifier.urihttp://hdl.handle.net/10722/187502-
dc.description.abstractOur group has shown that the polysaccharides extracted from Lycium barbarum (LBP) are neuroprotective for retinal ganglion cells (RGCs) in different animal models. Protecting RGCs from secondary degeneration is a promising direction for therapy in glaucoma management. The complete optic nerve transection (CONT) model can be used to study primary degeneration of RGCs, while the partial optic nerve transection (PONT) model can be used to study secondary degeneration of RGCs because primary degeneration of RGCs and secondary degeneration can be separated in location in the same retina in this model; in other situations, these types of degeneration can be difficult to distinguish. In order to examine which kind of degeneration LBP could delay, both CONT and PONT models were used in this study. Rats were fed with LBP or vehicle daily from 7 days before surgery until sacrifice at different time-points and the surviving numbers of RGCs were evaluated. The expression of several proteins related to inflammation, oxidative stress, and the c-jun N-terminal kinase (JNK) pathways were detected with Western-blot analysis. LBP did not delay primary degeneration of RGCs after either CONT or PONT, but it did delay secondary degeneration of RGCs after PONT. We found that LBP appeared to exert these protective effects by inhibiting oxidative stress and the JNK/c-jun pathway and by transiently increasing production of insulin-like growth factor-1 (IGF-1). This study suggests that LBP can delay secondary degeneration of RGCs and this effect may be linked to inhibition of oxidative stress and the JNK/c-jun pathway in the retina. © 2013 Li et al.-
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action-
dc.relation.ispartofPLoSen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleLycium Barbarum (wolfberry) reduces secondary degeneration and oxidative stress, and inhibits JNK pathway in retina after partial optic nerve transectionen_US
dc.typeArticleen_US
dc.identifier.emailLi, H: lhy2012@hku.hken_US
dc.identifier.emailLiang, Y: yxliang@hku.hken_US
dc.identifier.emailChiu, K: datwai@hkucc.hku.hken_US
dc.identifier.emailLin, B: blin@hku.hken_US
dc.identifier.emailChang, RCC: rccchang@hku.hken_US
dc.identifier.emailSo, KF: hrmaskf@hku.hken_US
dc.identifier.authorityLiang, Y=rp00510en_US
dc.identifier.authorityLin, B=rp01356en_US
dc.identifier.authorityChang, RCC=rp00470en_US
dc.identifier.authoritySo, KF=rp00329en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0068881-
dc.identifier.pmid23894366-
dc.identifier.scopuseid_2-s2.0-84880441470-
dc.identifier.hkuros220080en_US
dc.identifier.volume8en_US
dc.identifier.spage1en_US
dc.identifier.epage13en_US
dc.identifier.isiWOS:000322391400029-

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