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Conference Paper: Natural history in patients with normal or minimally elevated ALT

TitleNatural history in patients with normal or minimally elevated ALT
Authors
KeywordsMedical sciences
Gastroenterology
Issue Date2012
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH
Citation
The 2012 Asian Pacific Digestive Week (APDW 2012), Bangkok, Thailand, 5–8 December 2012. In Journal of Gastroenterology and Hepatology, 2012, v. 27 suppl. S5, p. 7, abstract S03-05 How to Cite?
AbstractAlthough serum alanine aminotransferase (ALT) has been used as a surrogate marker for liver diseases, its accuracy in reflecting liver damage has been questioned. This issue is further complicated by the recent challenge on the exact normal level of ALT. In studies examining the outcome of subjects with different ALT levels, it is found that ALT in the upper range of the traditionally defined normal levels is already associated with a higher risk of liver related complications and death. In the area of hepatitis B disease, many studies have confirmed by liver histology that a considerable proportion of patients with normal or minimally elevated ALT levels already have significant liver inflammatory and fibrotic activities. The most consistently found risk factors for significant fibrosis are male gender, increasing age and viral load (HBV DNA level). As far as the development of clinical complications of hepatitis B disease is concerned, patients with minimally elevated ALT levels are still at a considerable risk for the development of cirrhosis and hepatocellular carcinoma. Although this finding has been challenged for the ALT measurement to predict outcome being performed in a single time point, studies using median value and integration value of ALT levels over time during follow-up confirm that patients with minimally elevated ALT levels are at higher risk for development of liver related complications. Nevertheless, patients with persistently normal ALT (preferably men < 30; women < 19 U/L) do have a favourable prognosis.
DescriptionThis journal suppl. entatiled: Special Issue: Asian Pacific Digestive Week 2012 ...
Oral Presentation - Symposium 03. Epidemiology and Hepatitis B in Asia-Pacifi c: no. S03-05
Persistent Identifierhttp://hdl.handle.net/10722/186844
ISSN
2015 Impact Factor: 3.322
2015 SCImago Journal Rankings: 1.190

 

DC FieldValueLanguage
dc.contributor.authorYuen, MFen_US
dc.date.accessioned2013-08-20T12:21:13Z-
dc.date.available2013-08-20T12:21:13Z-
dc.date.issued2012en_US
dc.identifier.citationThe 2012 Asian Pacific Digestive Week (APDW 2012), Bangkok, Thailand, 5–8 December 2012. In Journal of Gastroenterology and Hepatology, 2012, v. 27 suppl. S5, p. 7, abstract S03-05en_US
dc.identifier.issn0815-9319-
dc.identifier.urihttp://hdl.handle.net/10722/186844-
dc.descriptionThis journal suppl. entatiled: Special Issue: Asian Pacific Digestive Week 2012 ...-
dc.descriptionOral Presentation - Symposium 03. Epidemiology and Hepatitis B in Asia-Pacifi c: no. S03-05-
dc.description.abstractAlthough serum alanine aminotransferase (ALT) has been used as a surrogate marker for liver diseases, its accuracy in reflecting liver damage has been questioned. This issue is further complicated by the recent challenge on the exact normal level of ALT. In studies examining the outcome of subjects with different ALT levels, it is found that ALT in the upper range of the traditionally defined normal levels is already associated with a higher risk of liver related complications and death. In the area of hepatitis B disease, many studies have confirmed by liver histology that a considerable proportion of patients with normal or minimally elevated ALT levels already have significant liver inflammatory and fibrotic activities. The most consistently found risk factors for significant fibrosis are male gender, increasing age and viral load (HBV DNA level). As far as the development of clinical complications of hepatitis B disease is concerned, patients with minimally elevated ALT levels are still at a considerable risk for the development of cirrhosis and hepatocellular carcinoma. Although this finding has been challenged for the ALT measurement to predict outcome being performed in a single time point, studies using median value and integration value of ALT levels over time during follow-up confirm that patients with minimally elevated ALT levels are at higher risk for development of liver related complications. Nevertheless, patients with persistently normal ALT (preferably men < 30; women < 19 U/L) do have a favourable prognosis.-
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH-
dc.relation.ispartofJournal of Gastroenterology and Hepatologyen_US
dc.rightsThe definitive version is available at www3.interscience.wiley.com-
dc.subjectMedical sciences-
dc.subjectGastroenterology-
dc.titleNatural history in patients with normal or minimally elevated ALTen_US
dc.typeConference_Paperen_US
dc.identifier.emailYuen, MF: mfyuen@hku.hken_US
dc.identifier.authorityYuen, MF=rp00479en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/jgh.12005-
dc.identifier.hkuros220781en_US
dc.identifier.volume27en_US
dc.identifier.issuesuppl. S5en_US
dc.identifier.spage7en_US
dc.identifier.epage7en_US
dc.publisher.placeAustralia-
dc.customcontrol.immutablesml 130903-

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