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Conference Paper: 11C-acetate and 18F-FDG dual tracer PET scan with contrast CT provide the most accurate histopathology prediction in HCC patients - a study of explant histopathology in the model of liver transplantation

Title11C-acetate and 18F-FDG dual tracer PET scan with contrast CT provide the most accurate histopathology prediction in HCC patients - a study of explant histopathology in the model of liver transplantation
Authors
KeywordsMedical sciences
Gastroenterology
Issue Date2012
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/
Citation
The 63rd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) - The Liver Meeting® 2012, Boston, MA., 9-13 November 2012. In Hepatology, 2012, v. 56 suppl. S1, p. 833A, abstract 1358 How to Cite?
AbstractBACKGROUND: All of the liver transplantation criteria for HCC depend heavily on tumor size and numbers. However, the sensitivity of contrast CT scan and MRI ...
BACKGROUND: All of the liver transplantation criteria for HCC depend heavily on tumor size and numbers. However, the sensitivity of contrast CT scan and MRI is far from satisfactory. We investigated whether contrast computed tomography (CT) together with positron emission tomography (PET) using two tracers, 11C-acetate and 18F-FDG, provides a more accurate prediction of histopathological status by comparing directly to the liver explants. METHOD: Data of 44 HCC patients having the dual-tracer PET together with contrast CT before surgery between January 2004 and September 2011 were reviewed. Eleven patients underwent deceased donor liver transplantation and 33 patients underwent living donor liver transplantation. All patients had HCC proven by histopathological assessment. RESULTS of HCC staging in terms of the size and number yielded by contrast CT, 18F-FDG PET and dual-tracer PET with contrast CT were compared with histopathology after surgery. Results: A total 72 tumors were identified in these 44 patients. The median tumour number were 1 (range1-5) and the median size was 3.75cm (range 1-8cm) from the final pathology. The overall accurate prediction of final histopathology in terms of UCSF criteria by contrast CT scan alone was 21/44 (47.7%), by FDG alone was 13/44 (29.5%), by 11C acetate alone 32/44 (72.7%) and by overall combination of 3 assessment was 33/44 (75%) (p=0.000*) From the pathological examination, there were 4 tumors < 1cm, the sensitivity by contrast CT scan alone, by 18FDG alone, by 11C acetate alone and by overall combination of 3 assessment were 0%, 25%, 25%, and 25% respectively (p=0.746). There were 23 tumours range from 1- 2 cm, the sensitivity by contrast CT scan alone, by 18FDG alone, by 11C acetate alone and by overall combination of 3 assessment were 60.9%, 17.4%, 73.9%, and 78.3% respectively (p=0.000*). There were 45 tumours > 2cm, the sensitivity by contrast CT scan alone, by 18FDG alone, by 11C acetate alone and by overall combination of 3 assessment were 71.1%, 40%, 86.7%, and 91.1% respectively (p=0.000*) CONCLUSION: For lesions > 1 cm, dual-tracer PET together with contrast CT provided the most accurate prediction of explants histopathology in terms of tumor size and number for patients undergoing liver transplantation for HCC. Its implementation in liver transplant work-up is recommended.
DescriptionPoster Presentation
This journal suppl. entitled: Supplement: The 63rd Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2012
Persistent Identifierhttp://hdl.handle.net/10722/186839
ISSN
2015 Impact Factor: 11.711
2015 SCImago Journal Rankings: 4.752

 

DC FieldValueLanguage
dc.contributor.authorCheung, TTen_US
dc.contributor.authorChan, SCen_US
dc.contributor.authorHo, CLen_US
dc.contributor.authorChok, KSHen_US
dc.contributor.authorChan, Aen_US
dc.contributor.authorFung, Jen_US
dc.contributor.authorChen, Sen_US
dc.contributor.authorPoon, RTen_US
dc.contributor.authorFan, STen_US
dc.contributor.authorLo, CMen_US
dc.date.accessioned2013-08-20T12:21:13Z-
dc.date.available2013-08-20T12:21:13Z-
dc.date.issued2012en_US
dc.identifier.citationThe 63rd Annual Meeting of the American Association for the Study of Liver Diseases (AASLD) - The Liver Meeting® 2012, Boston, MA., 9-13 November 2012. In Hepatology, 2012, v. 56 suppl. S1, p. 833A, abstract 1358en_US
dc.identifier.issn0270-9139-
dc.identifier.urihttp://hdl.handle.net/10722/186839-
dc.descriptionPoster Presentation-
dc.descriptionThis journal suppl. entitled: Supplement: The 63rd Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 2012-
dc.description.abstractBACKGROUND: All of the liver transplantation criteria for HCC depend heavily on tumor size and numbers. However, the sensitivity of contrast CT scan and MRI ...-
dc.description.abstractBACKGROUND: All of the liver transplantation criteria for HCC depend heavily on tumor size and numbers. However, the sensitivity of contrast CT scan and MRI is far from satisfactory. We investigated whether contrast computed tomography (CT) together with positron emission tomography (PET) using two tracers, 11C-acetate and 18F-FDG, provides a more accurate prediction of histopathological status by comparing directly to the liver explants. METHOD: Data of 44 HCC patients having the dual-tracer PET together with contrast CT before surgery between January 2004 and September 2011 were reviewed. Eleven patients underwent deceased donor liver transplantation and 33 patients underwent living donor liver transplantation. All patients had HCC proven by histopathological assessment. RESULTS of HCC staging in terms of the size and number yielded by contrast CT, 18F-FDG PET and dual-tracer PET with contrast CT were compared with histopathology after surgery. Results: A total 72 tumors were identified in these 44 patients. The median tumour number were 1 (range1-5) and the median size was 3.75cm (range 1-8cm) from the final pathology. The overall accurate prediction of final histopathology in terms of UCSF criteria by contrast CT scan alone was 21/44 (47.7%), by FDG alone was 13/44 (29.5%), by 11C acetate alone 32/44 (72.7%) and by overall combination of 3 assessment was 33/44 (75%) (p=0.000*) From the pathological examination, there were 4 tumors < 1cm, the sensitivity by contrast CT scan alone, by 18FDG alone, by 11C acetate alone and by overall combination of 3 assessment were 0%, 25%, 25%, and 25% respectively (p=0.746). There were 23 tumours range from 1- 2 cm, the sensitivity by contrast CT scan alone, by 18FDG alone, by 11C acetate alone and by overall combination of 3 assessment were 60.9%, 17.4%, 73.9%, and 78.3% respectively (p=0.000*). There were 45 tumours > 2cm, the sensitivity by contrast CT scan alone, by 18FDG alone, by 11C acetate alone and by overall combination of 3 assessment were 71.1%, 40%, 86.7%, and 91.1% respectively (p=0.000*) CONCLUSION: For lesions > 1 cm, dual-tracer PET together with contrast CT provided the most accurate prediction of explants histopathology in terms of tumor size and number for patients undergoing liver transplantation for HCC. Its implementation in liver transplant work-up is recommended.-
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/-
dc.relation.ispartofHepatologyen_US
dc.rightsHepatology. Copyright © John Wiley & Sons, Inc.-
dc.subjectMedical sciences-
dc.subjectGastroenterology-
dc.title11C-acetate and 18F-FDG dual tracer PET scan with contrast CT provide the most accurate histopathology prediction in HCC patients - a study of explant histopathology in the model of liver transplantationen_US
dc.typeConference_Paperen_US
dc.identifier.emailCheung, TT: cheung68@hku.hken_US
dc.identifier.emailChan, SC: chanlsc@hkucc.hku.hken_US
dc.identifier.emailChan, A: acchan@hku.hken_US
dc.identifier.emailFung, J: jfung@hkucc.hku.hken_US
dc.identifier.emailPoon, RT: poontp@hku.hken_US
dc.identifier.emailFan, ST: stfan@hku.hken_US
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_US
dc.identifier.authorityChan, SC=rp01568en_US
dc.identifier.authorityChan, A=rp00310en_US
dc.identifier.authorityFung, J=rp00518en_US
dc.identifier.authorityPoon, RT=rp00446en_US
dc.identifier.authorityFan, ST=rp00355en_US
dc.identifier.authorityLo, CM=rp00412en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/hep.26040-
dc.identifier.hkuros220347en_US
dc.identifier.volume56en_US
dc.identifier.issuesuppl. S1en_US
dc.identifier.spage833A, abstract 1358en_US
dc.identifier.epage833A, abstract 1358en_US
dc.publisher.placeUnited States-
dc.customcontrol.immutablesml 130905-

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