File Download
  Links for fulltext
     (May Require Subscription)
  • Find via Find It@HKUL
Supplementary

Conference Paper: Anti-annexin II level in serum correlates with disease manifestations in lupus nephritis

TitleAnti-annexin II level in serum correlates with disease manifestations in lupus nephritis
Authors
Issue Date2012
PublisherAmerican Society of Nephrology. The Journal's web site is located at http://www.jasn.org
Citation
The 45th Annual Meeting of the American Society of Nephrology (Kidney Week 2012), San Diego, CA., 30 October-4 November 2012. In Journal of the American Society of Nephrology, v. 2012 meeting abstracts, p. 567A, FR-PO867 How to Cite?
AbstractBACKGROUND: We have reported that anti-dsDNA antibodies from patients with lupus nephritis could bind to annexin II on the surface of human mesangial cells and mediate downstream inflammatory processes. In this study we investigated the relationship between serum anti-annexin II activity, measured with ELISA, and clinical parameters. METHODS: Serial serum samples from 23 patients with biopsy-proven severe proliferative lupus nephritis were included. Sera from patients with non-lupus renal diseases and healthy subjects were used as controls. RESULTS: A total of 487 serum samples were from patients with lupus nephritis, including 97 during active disease and 390 samples during remission. IgG anti-annexin II activity was significantly higher in patients with lupus nephritis compared with controls (P<0.001). Sero-positivity rate for anti-annexin II IgG was 20.3%, 5.3%, and 3.1% in patients with lupus nephritis, non-lupus glomerular diseases, and healthy controls respectively (P<0.001 for both). Anti-annexin II titre (IgG) correlated with the level of anti-dsDNA antibodies (r=0.26, P<0.001), total IgG (r=0.45, P<0.0001), and serum creatinine (r=0.45, P<0.001), while there was an inverse correlation with C3 level (r=-0.31, P<0.001). In 15 of 23 patients investigated, the levels of anti-annexin II and anti-dsDNA were both higher during active disease than during remission. CONCLUSIONS: The data show that IgG anti-annexin II titre correlates with serological and clinical markers indicating disease activity in lupus nephritis.
DescriptionSession: Probing the Immune Basis of Glomerular and Intersitial Kidney Diseases - I (Poster): FR-PO867
Open Access Journal
Abstract Supplement of JASN is located at http://www.asn-online.org/education/kidneyweek/archives/
Persistent Identifierhttp://hdl.handle.net/10722/186819
ISSN
2015 Impact Factor: 8.491
2015 SCImago Journal Rankings: 4.699

 

DC FieldValueLanguage
dc.contributor.authorChan, DTMen_US
dc.contributor.authorCheung, KFen_US
dc.contributor.authorYim, Aen_US
dc.contributor.authorYap, DYHen_US
dc.contributor.authorYung, Sen_US
dc.date.accessioned2013-08-20T12:21:08Z-
dc.date.available2013-08-20T12:21:08Z-
dc.date.issued2012en_US
dc.identifier.citationThe 45th Annual Meeting of the American Society of Nephrology (Kidney Week 2012), San Diego, CA., 30 October-4 November 2012. In Journal of the American Society of Nephrology, v. 2012 meeting abstracts, p. 567A, FR-PO867en_US
dc.identifier.issn1046-6673en_US
dc.identifier.urihttp://hdl.handle.net/10722/186819-
dc.descriptionSession: Probing the Immune Basis of Glomerular and Intersitial Kidney Diseases - I (Poster): FR-PO867en_US
dc.descriptionOpen Access Journal-
dc.descriptionAbstract Supplement of JASN is located at http://www.asn-online.org/education/kidneyweek/archives/-
dc.description.abstractBACKGROUND: We have reported that anti-dsDNA antibodies from patients with lupus nephritis could bind to annexin II on the surface of human mesangial cells and mediate downstream inflammatory processes. In this study we investigated the relationship between serum anti-annexin II activity, measured with ELISA, and clinical parameters. METHODS: Serial serum samples from 23 patients with biopsy-proven severe proliferative lupus nephritis were included. Sera from patients with non-lupus renal diseases and healthy subjects were used as controls. RESULTS: A total of 487 serum samples were from patients with lupus nephritis, including 97 during active disease and 390 samples during remission. IgG anti-annexin II activity was significantly higher in patients with lupus nephritis compared with controls (P<0.001). Sero-positivity rate for anti-annexin II IgG was 20.3%, 5.3%, and 3.1% in patients with lupus nephritis, non-lupus glomerular diseases, and healthy controls respectively (P<0.001 for both). Anti-annexin II titre (IgG) correlated with the level of anti-dsDNA antibodies (r=0.26, P<0.001), total IgG (r=0.45, P<0.0001), and serum creatinine (r=0.45, P<0.001), while there was an inverse correlation with C3 level (r=-0.31, P<0.001). In 15 of 23 patients investigated, the levels of anti-annexin II and anti-dsDNA were both higher during active disease than during remission. CONCLUSIONS: The data show that IgG anti-annexin II titre correlates with serological and clinical markers indicating disease activity in lupus nephritis.en_US
dc.languageengen_US
dc.publisherAmerican Society of Nephrology. The Journal's web site is located at http://www.jasn.orgen_US
dc.relation.ispartofJournal of the American Society of Nephrologyen_US
dc.titleAnti-annexin II level in serum correlates with disease manifestations in lupus nephritisen_US
dc.typeConference_Paperen_US
dc.identifier.emailChan, DTM: dtmchan@hku.hken_US
dc.identifier.emailCheung, KF: skfc819@hku.hken_US
dc.identifier.emailYim, A: anndyim@hku.hken_US
dc.identifier.emailYap, DYH: desmondy@hku.hken_US
dc.identifier.emailYung, S: ssyyung@hku.hken_US
dc.identifier.authorityChan, DTM=rp00394en_US
dc.identifier.authorityYap, DYH=rp01607en_US
dc.identifier.authorityYung, S=rp00455en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros218213en_US
dc.identifier.volume2012en_US
dc.identifier.issuemeeting abstractsen_US
dc.identifier.spage567Aen_US
dc.identifier.epage567Aen_US
dc.publisher.placeUnited Statesen_US
dc.customcontrol.immutablesml 130902-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats