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Conference Paper: Rho GTPase-activating protein DLC2 deficiency in mice leads to more severe painful diabetic neuropathy

TitleRho GTPase-activating protein DLC2 deficiency in mice leads to more severe painful diabetic neuropathy
Authors
Issue Date2013
Citation
The 73rd Scientific Sessions of the American Diabetes Association (ADA), Chicago, IL., 21-25 June 2013. How to Cite?
AbstractDLC2, a Rho GTPase-activating protein with specific activity for RhoA, has been shown to play a role in pain response. Mice deficient for this protein (DLC2 KO) are hyperalgesic compared to wild type in acute pain tests, showing higher response to noxious thermal and inflammatory stimuli, while also showing an increase in RhoA activity in peripheral nerves. Because of the increased acute pain response in DLC2 KO mice, and since RhoA is known to be involved in the development and maintenance of diabetic complications, we used them to study chronic pain in a model of diabetic neuropathy. Wild type (DLC2 WT) and DLC2 KO mice were subjected to multiple low dose streptozotocin (MLDS) treatment to induce diabetes. After 8 weeks, their pain response was tested. From the hot plate test, diabetic DLC2 ...
DescriptionGPS03. General Poster Session 3: abstract no. 580-P
Persistent Identifierhttp://hdl.handle.net/10722/186561

 

DC FieldValueLanguage
dc.contributor.authorTirrell, Len_US
dc.contributor.authorCheung, CWen_US
dc.contributor.authorChung, SKen_US
dc.date.accessioned2013-08-20T12:13:26Z-
dc.date.available2013-08-20T12:13:26Z-
dc.date.issued2013en_US
dc.identifier.citationThe 73rd Scientific Sessions of the American Diabetes Association (ADA), Chicago, IL., 21-25 June 2013.en_US
dc.identifier.urihttp://hdl.handle.net/10722/186561-
dc.descriptionGPS03. General Poster Session 3: abstract no. 580-P-
dc.description.abstractDLC2, a Rho GTPase-activating protein with specific activity for RhoA, has been shown to play a role in pain response. Mice deficient for this protein (DLC2 KO) are hyperalgesic compared to wild type in acute pain tests, showing higher response to noxious thermal and inflammatory stimuli, while also showing an increase in RhoA activity in peripheral nerves. Because of the increased acute pain response in DLC2 KO mice, and since RhoA is known to be involved in the development and maintenance of diabetic complications, we used them to study chronic pain in a model of diabetic neuropathy. Wild type (DLC2 WT) and DLC2 KO mice were subjected to multiple low dose streptozotocin (MLDS) treatment to induce diabetes. After 8 weeks, their pain response was tested. From the hot plate test, diabetic DLC2 ...-
dc.languageengen_US
dc.relation.ispartof73rd ADA Scientific Sessions 2013en_US
dc.titleRho GTPase-activating protein DLC2 deficiency in mice leads to more severe painful diabetic neuropathyen_US
dc.typeConference_Paperen_US
dc.identifier.emailChung, SK: skchung@hkucc.hku.hken_US
dc.identifier.authorityChung, SK=rp00381en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.2337/db13-388-679-
dc.identifier.hkuros216729en_US

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