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Article: Intestinal absorption and bioavailability of traditional Chinese medicines: a review of recent experimental progress and implication for quality control

TitleIntestinal absorption and bioavailability of traditional Chinese medicines: a review of recent experimental progress and implication for quality control
Authors
Issue Date2013
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.wiley.com/WileyCDA/WileyTitle/productCd-JPHP.html
Citation
Journal of pharmacy and pharmacology, 2013, v. 65 n. 5, p. 621-633 How to Cite?
AbstractOBJECTIVES: Experimental studies on the pharmacokinetics of traditional Chinese medicines (TCMs) have achieved great progress in recent years. This review aims to summarize the progress made on intestinal absorption and bioavailability of TCMs, and proposes the application of intestinal absorption assays as new tools for the quality and safety control of these medicines. KEY FINDINGS: Since only the absorbed constituents may produce possible therapeutic effect (except those that directly target the digestive tract), intestinal absorption is of utmost importance for the drug action of TCMs, which are usually taken orally. Meanwhile, complicated drug interactions may occur among the multiple ingredients in a herbal mixture. In this regard, the intestinal permeability assays not only provide useful pharmacokinetic data of TCMs, but have potential applications for quality and safety control. Moreover, knockout animals, 2/4/A1 in-vitro cell model and physiologically-based in-silico models based on the online TCM database can be quite useful for the prediction of absorption and bioavailability of TCMs. SUMMARY: A variety of in-vivo, in-vitro, in-situ and in-silico models for predicting the intestinal absorption and bioavailability can be applied to study the herbal interactions and screen appropriate biomarkers for the quality and safety control of TCMs.
Persistent Identifierhttp://hdl.handle.net/10722/185999
ISSN
2015 Impact Factor: 2.363
2015 SCImago Journal Rankings: 0.686
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, JYen_US
dc.contributor.authorLee, CKFen_US
dc.contributor.authorSze, CWen_US
dc.contributor.authorTong, Yen_US
dc.contributor.authorTang, SCWen_US
dc.contributor.authorNg, TBen_US
dc.contributor.authorZhang, YBen_US
dc.date.accessioned2013-08-20T11:49:48Z-
dc.date.available2013-08-20T11:49:48Z-
dc.date.issued2013en_US
dc.identifier.citationJournal of pharmacy and pharmacology, 2013, v. 65 n. 5, p. 621-633en_US
dc.identifier.issn0022-3573-
dc.identifier.urihttp://hdl.handle.net/10722/185999-
dc.description.abstractOBJECTIVES: Experimental studies on the pharmacokinetics of traditional Chinese medicines (TCMs) have achieved great progress in recent years. This review aims to summarize the progress made on intestinal absorption and bioavailability of TCMs, and proposes the application of intestinal absorption assays as new tools for the quality and safety control of these medicines. KEY FINDINGS: Since only the absorbed constituents may produce possible therapeutic effect (except those that directly target the digestive tract), intestinal absorption is of utmost importance for the drug action of TCMs, which are usually taken orally. Meanwhile, complicated drug interactions may occur among the multiple ingredients in a herbal mixture. In this regard, the intestinal permeability assays not only provide useful pharmacokinetic data of TCMs, but have potential applications for quality and safety control. Moreover, knockout animals, 2/4/A1 in-vitro cell model and physiologically-based in-silico models based on the online TCM database can be quite useful for the prediction of absorption and bioavailability of TCMs. SUMMARY: A variety of in-vivo, in-vitro, in-situ and in-silico models for predicting the intestinal absorption and bioavailability can be applied to study the herbal interactions and screen appropriate biomarkers for the quality and safety control of TCMs.-
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www.wiley.com/WileyCDA/WileyTitle/productCd-JPHP.html-
dc.relation.ispartofJournal of pharmacy and pharmacologyen_US
dc.titleIntestinal absorption and bioavailability of traditional Chinese medicines: a review of recent experimental progress and implication for quality controlen_US
dc.typeArticleen_US
dc.identifier.emailLee, CKF: ckflee@hku.hken_US
dc.identifier.emailSze, CW: stephens@hku.hken_US
dc.identifier.emailTong, Y: tongyao@hku.hken_US
dc.identifier.emailTang, SCW: scwtang@hku.hken_US
dc.identifier.emailZhang, YB: ybzhang@hku.hken_US
dc.identifier.authorityLee, CKF=rp00458en_US
dc.identifier.authoritySze, CW=rp00514en_US
dc.identifier.authorityTong, Y=rp00509en_US
dc.identifier.authorityTang, SCW=rp00480en_US
dc.identifier.authorityZhang, YB=rp01410en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/j.2042-7158.2012.01608.x-
dc.identifier.pmid23600379-
dc.identifier.hkuros217958en_US
dc.identifier.hkuros219446-
dc.identifier.volume65en_US
dc.identifier.issue5en_US
dc.identifier.spage621en_US
dc.identifier.epage633en_US
dc.identifier.isiWOS:000318080100001-
dc.publisher.placeUnited Kingdom-

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