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Article: A Synthetic Chloride Channel Relaxes Airway Smooth Muscle of the Rat

TitleA Synthetic Chloride Channel Relaxes Airway Smooth Muscle of the Rat
Authors
Issue Date2012
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
PLOS One, 2012, v. 7, p. e45340 How to Cite?
AbstractSynthetic ion channels may have potential therapeutic applications, provided they possess appropriate biological activities. The present study was designed to examine the ability of small molecule-based synthetic Cl– channels to modulate airway smooth muscle responsiveness. Changes in isometric tension were measured in rat tracheal rings. Relaxations to the synthetic chloride channel SCC-1 were obtained during sustained contractions to KCl. The anion dependency of the effect of SCC-1 was evaluated by ion substitution experiments. The sensitivity to conventional Cl– transport inhibitors was also tested. SCC-1 caused concentration-dependent relaxations during sustained contractions to potassium chloride. This relaxing effect was dependent on the presence of extracellular Cl– and HCO3−. It was insensitive to conventional Cl– channels/transport inhibitors that blocked the cystic fibrosis transmembrane conductance regulator and calcium-activated Cl– channels. SCC-1 did not inhibit contractions induced by carbachol, endothelin-1, 5-hydroxytryptamine or the calcium ionophore A23187. SCC-1 relaxes airway smooth muscle during contractions evoked by depolarizing solutions. The Cl– conductance conferred by this synthetic compound is distinct from the endogenous transport systems for chloride anions.
Persistent Identifierhttp://hdl.handle.net/10722/185988
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYau, KH-
dc.contributor.authorMak, JCW-
dc.contributor.authorLeung, SWS-
dc.contributor.authorYang, D-
dc.contributor.authorVanhoutte, PMGR-
dc.date.accessioned2013-08-20T11:49:40Z-
dc.date.available2013-08-20T11:49:40Z-
dc.date.issued2012-
dc.identifier.citationPLOS One, 2012, v. 7, p. e45340-
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10722/185988-
dc.description.abstractSynthetic ion channels may have potential therapeutic applications, provided they possess appropriate biological activities. The present study was designed to examine the ability of small molecule-based synthetic Cl– channels to modulate airway smooth muscle responsiveness. Changes in isometric tension were measured in rat tracheal rings. Relaxations to the synthetic chloride channel SCC-1 were obtained during sustained contractions to KCl. The anion dependency of the effect of SCC-1 was evaluated by ion substitution experiments. The sensitivity to conventional Cl– transport inhibitors was also tested. SCC-1 caused concentration-dependent relaxations during sustained contractions to potassium chloride. This relaxing effect was dependent on the presence of extracellular Cl– and HCO3−. It was insensitive to conventional Cl– channels/transport inhibitors that blocked the cystic fibrosis transmembrane conductance regulator and calcium-activated Cl– channels. SCC-1 did not inhibit contractions induced by carbachol, endothelin-1, 5-hydroxytryptamine or the calcium ionophore A23187. SCC-1 relaxes airway smooth muscle during contractions evoked by depolarizing solutions. The Cl– conductance conferred by this synthetic compound is distinct from the endogenous transport systems for chloride anions.-
dc.languageeng-
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action-
dc.relation.ispartofPLOS One-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleA Synthetic Chloride Channel Relaxes Airway Smooth Muscle of the Rat-
dc.typeArticle-
dc.identifier.emailMak, JCW: judymak@hku.hk-
dc.identifier.emailLeung, SWS: swsleung@hku.hk-
dc.identifier.emailYang, D: yangdan@hku.hk-
dc.identifier.emailVanhoutte, PMGR: vanhoutt@hku.hk-
dc.identifier.authorityMak, JCW=rp00352-
dc.identifier.authorityLeung, SWS=rp00235-
dc.identifier.authorityYang, D=rp00825-
dc.identifier.authorityVanhoutte, PMGR=rp00238-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1371/journal.pone.0045340-
dc.identifier.pmid23049786-
dc.identifier.pmcidPMC3458840-
dc.identifier.hkuros217585-
dc.identifier.volume7-
dc.identifier.spagee45340-
dc.identifier.epagee45340-
dc.identifier.isiWOS:000309517300021-
dc.publisher.placeUnited States-

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