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Article: An ytterbium(III) porphyrin induces endoplasmic reticulum stress and apoptosis in cancer cells: cytotoxicity and transcriptomics studies

TitleAn ytterbium(III) porphyrin induces endoplasmic reticulum stress and apoptosis in cancer cells: cytotoxicity and transcriptomics studies
Authors
Issue Date2013
PublisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/publishing/journals/sc/About.asp
Citation
Chemical Science, 2013, v. 4 n. 2, p. 747-754 How to Cite?
AbstractIn the literature, very few ytterbium(iii) complexes have been reported to display promising anti-cancer activities without photoactivation or conjugation to cytotoxic counterparts/radionuclides. By employing porphyrinato ligands, which provide a rigid molecular scaffold for the ytterbium(iii) ion and enhance cellular-uptake efficacy, we have prepared and structurally characterized a series of ytterbium(iii) porphyrin complexes showing potent anti-cancer activities with cytotoxic IC50 values down to the sub-micromolar range. The notable example is an ytterbium(iii) octaethylporphyrin complex (1) which exists as a dimeric hydroxyl-bridged complex [Yb2(OEP) 2(μ-OH)2] (where H2OEP = octaethylporphyrin) in CH2Cl2 solution and in solid state, and as monomeric [Yb(OEP)(DMSO)(OH)(OH2)] in DMSO/aqueous solution. Unlike various anti-cancer lanthanide complexes which are proposed to target cellular DNA, transcriptomics data, bioinformatics connectivity map analysis and biochemical experiments altogether indicate that 1 exerts its anti-cancer effect through apoptosis that is highly associated with the endoplasmic reticulum stress pathway. © The Royal Society of Chemistry 2013.
Persistent Identifierhttp://hdl.handle.net/10722/185699
ISSN
2015 Impact Factor: 9.144
2015 SCImago Journal Rankings: 4.974
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKwong, WL-
dc.contributor.authorSun, RWY-
dc.contributor.authorLok, CN-
dc.contributor.authorSiu, AFM-
dc.contributor.authorWong, SY-
dc.contributor.authorLow, KH-
dc.contributor.authorChe, CM-
dc.date.accessioned2013-08-20T11:37:31Z-
dc.date.available2013-08-20T11:37:31Z-
dc.date.issued2013-
dc.identifier.citationChemical Science, 2013, v. 4 n. 2, p. 747-754-
dc.identifier.issn2041-6520-
dc.identifier.urihttp://hdl.handle.net/10722/185699-
dc.description.abstractIn the literature, very few ytterbium(iii) complexes have been reported to display promising anti-cancer activities without photoactivation or conjugation to cytotoxic counterparts/radionuclides. By employing porphyrinato ligands, which provide a rigid molecular scaffold for the ytterbium(iii) ion and enhance cellular-uptake efficacy, we have prepared and structurally characterized a series of ytterbium(iii) porphyrin complexes showing potent anti-cancer activities with cytotoxic IC50 values down to the sub-micromolar range. The notable example is an ytterbium(iii) octaethylporphyrin complex (1) which exists as a dimeric hydroxyl-bridged complex [Yb2(OEP) 2(μ-OH)2] (where H2OEP = octaethylporphyrin) in CH2Cl2 solution and in solid state, and as monomeric [Yb(OEP)(DMSO)(OH)(OH2)] in DMSO/aqueous solution. Unlike various anti-cancer lanthanide complexes which are proposed to target cellular DNA, transcriptomics data, bioinformatics connectivity map analysis and biochemical experiments altogether indicate that 1 exerts its anti-cancer effect through apoptosis that is highly associated with the endoplasmic reticulum stress pathway. © The Royal Society of Chemistry 2013.-
dc.languageeng-
dc.publisherRoyal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/publishing/journals/sc/About.asp-
dc.relation.ispartofChemical Science-
dc.titleAn ytterbium(III) porphyrin induces endoplasmic reticulum stress and apoptosis in cancer cells: cytotoxicity and transcriptomics studies-
dc.typeArticle-
dc.identifier.emailKwong, WL: kwongwl@hku.hk-
dc.identifier.emailSun, RWY: rwysun@hku.hk-
dc.identifier.emailLok, CN: cnlok@hku.hk-
dc.identifier.emailSiu, AFM: fmsiu@hku.hk-
dc.identifier.emailLow, KH: khlow@hku.hk-
dc.identifier.emailChe, CM: cmche@hku.hk-
dc.identifier.authoritySun, RWY=rp00781-
dc.identifier.authorityLok, CN=rp00752-
dc.identifier.authoritySiu, AFM=rp00776-
dc.identifier.authorityChe, CM=rp00670-
dc.identifier.doi10.1039/C2SC21541A-
dc.identifier.scopuseid_2-s2.0-84872081130-
dc.identifier.hkuros219332-
dc.identifier.volume4-
dc.identifier.issue2-
dc.identifier.spage747-
dc.identifier.epage754-
dc.identifier.isiWOS:000312946500026-
dc.publisher.placeUnited Kingdom-

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