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Conference Paper: Increased Risk Of Colorectal Malignant Neoplasm In Patients With Nonalcoholic Fatty Liver Disease: A Large Case–Control Study

TitleIncreased Risk Of Colorectal Malignant Neoplasm In Patients With Nonalcoholic Fatty Liver Disease: A Large Case–Control Study
Authors
Issue Date2013
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep
Citation
The 48th Annual Meeting of the European Association for the Study of the Liver, Amsterdam, The Netherlands, 24-28 April 2013. In Journal of Hepatology, 2013, v. 58 n. Suppl. 1, p. S555, abstract no. 1380 How to Cite?
AbstractBackground and Aims: Nonalcoholic fatty liver disease (NAFLD) has been suggested to be a strong risk factor of colorectal benign adenomas and advanced neoplasms. The aim of this large case– control study was to further investigate the prevalence of colorectal malignant neoplasm (CRMN) in patients with NAFLD and determine whether association between NAFLD and CRMN exists. Methods: 2315 community subjects (1370 males and 945 females) who underwent a routine colonoscopy according to international colorectal cancer screening guideline were recruited. Nature of colorectal lesions determined by biopsy and NAFLD was diagnosed by ultrasound. Binary logistic regression analysis was applied to explore the related associations. Results: Prevalence of CRMN was 29.3% (77/263) in patients with NAFLD, which was significantly higher than 18.0% (369/2052) in the control group (P<0.05). In addition, malignant neoplasm in NAFLD group occurred more frequently at sigmoid colon than in control group (14.3% vs. 11.9%). The incidence of highly-differentiated colorectal adenocarcinoma in NAFLD group was significantly higher than control group (62.3% vs. 9.8%). Univariate analysis showed that NAFLD had strong association with CRMN (OR, 2.043; 95% CI, 1.512– 2.761; P<0.05). After adjusting for metabolic and other confounding factors, NAFLD remained as an independent risk factor for CRMN (OR, 1.868; 95% CI, 1.360–2.567; P<0.05). Conclusion: NAFLD was an independent risk factor for CRMN. Sigmoid carcinoma and highly differentiated colorectal adenocarcinoma were more commonly found in NAFLD. (ClinicalTrials.gov number: NCT01657773).
DescriptionFulltext in: http://www2.kenes.com/liver-congress/scientific/Documents/Abstract_book.pdf
Poster Session: 10b. Fatty Liver Disease: Clinical
Persistent Identifierhttp://hdl.handle.net/10722/185003
ISSN
2015 Impact Factor: 10.59
2015 SCImago Journal Rankings: 4.570

 

DC FieldValueLanguage
dc.contributor.authorZheng, MHen_US
dc.contributor.authorLin, XFen_US
dc.contributor.authorShi, KQen_US
dc.contributor.authorYou, Jen_US
dc.contributor.authorLiu, WYen_US
dc.contributor.authorLup, YWen_US
dc.contributor.authorWong, DKHen_US
dc.contributor.authorYuen, RMFen_US
dc.contributor.authorChen, YPen_US
dc.date.accessioned2013-07-15T10:23:46Z-
dc.date.available2013-07-15T10:23:46Z-
dc.date.issued2013en_US
dc.identifier.citationThe 48th Annual Meeting of the European Association for the Study of the Liver, Amsterdam, The Netherlands, 24-28 April 2013. In Journal of Hepatology, 2013, v. 58 n. Suppl. 1, p. S555, abstract no. 1380en_US
dc.identifier.issn0168-8278-
dc.identifier.urihttp://hdl.handle.net/10722/185003-
dc.descriptionFulltext in: http://www2.kenes.com/liver-congress/scientific/Documents/Abstract_book.pdf-
dc.descriptionPoster Session: 10b. Fatty Liver Disease: Clinical-
dc.description.abstractBackground and Aims: Nonalcoholic fatty liver disease (NAFLD) has been suggested to be a strong risk factor of colorectal benign adenomas and advanced neoplasms. The aim of this large case– control study was to further investigate the prevalence of colorectal malignant neoplasm (CRMN) in patients with NAFLD and determine whether association between NAFLD and CRMN exists. Methods: 2315 community subjects (1370 males and 945 females) who underwent a routine colonoscopy according to international colorectal cancer screening guideline were recruited. Nature of colorectal lesions determined by biopsy and NAFLD was diagnosed by ultrasound. Binary logistic regression analysis was applied to explore the related associations. Results: Prevalence of CRMN was 29.3% (77/263) in patients with NAFLD, which was significantly higher than 18.0% (369/2052) in the control group (P<0.05). In addition, malignant neoplasm in NAFLD group occurred more frequently at sigmoid colon than in control group (14.3% vs. 11.9%). The incidence of highly-differentiated colorectal adenocarcinoma in NAFLD group was significantly higher than control group (62.3% vs. 9.8%). Univariate analysis showed that NAFLD had strong association with CRMN (OR, 2.043; 95% CI, 1.512– 2.761; P<0.05). After adjusting for metabolic and other confounding factors, NAFLD remained as an independent risk factor for CRMN (OR, 1.868; 95% CI, 1.360–2.567; P<0.05). Conclusion: NAFLD was an independent risk factor for CRMN. Sigmoid carcinoma and highly differentiated colorectal adenocarcinoma were more commonly found in NAFLD. (ClinicalTrials.gov number: NCT01657773).-
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhep-
dc.relation.ispartofJournal of Hepatologyen_US
dc.titleIncreased Risk Of Colorectal Malignant Neoplasm In Patients With Nonalcoholic Fatty Liver Disease: A Large Case–Control Studyen_US
dc.typeConference_Paperen_US
dc.identifier.emailWong, DKH: danywong@hku.hken_US
dc.identifier.emailYuen, RMF: mfyuen@hku.hken_US
dc.identifier.authorityWong, DKH=rp00492en_US
dc.identifier.authorityYuen, RMF=rp00479en_US
dc.identifier.doi10.1016/S0168-8278(13)61379-3-
dc.identifier.hkuros215586en_US
dc.identifier.volume58en_US
dc.identifier.issueSuppl. 1-
dc.identifier.spageS555, abstract no. 1380en_US
dc.identifier.epageS555, abstract no. 1380en_US
dc.publisher.placeNetherlands-

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