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Article: Direct retino-raphe projection alters serotonergic tone and affective behavior

TitleDirect retino-raphe projection alters serotonergic tone and affective behavior
Authors
Issue Date2013
PublisherNature Publishing Group. The Journal's web site is located at http://www.neuropsychopharmacology.org
Citation
Neuropsychopharmacology, 2013, v. 38 n. 7, p. 1163-1175 How to Cite?
AbstractLight is a powerful modulator of higher-order cognitive processes such as mood but it remains unclear which neural circuits mediate the impact of light on affective behavior. We found that light deprivation produces a depressive-like behavioral state that is reversed by activation of direct retinal signals to the serotonergic dorsal raphe nucleus (DRN) in a manner equivalent to treatment with the selective serotonin reuptake inhibitor fluoxetine. Surprisingly, the DRN-projecting retinal ganglion cells (RGCs) are indistinguishable from the classic alpha/Y-like RGC type that contributes to image-forming visual pathways. Silencing RGC firing or specific immunotoxin ablation of DRN-projecting RGCs increased depressive-like behavior and reduced serotonin levels in the DRN. Serotonin has a key role in the pathophysiology of depression, and these results demonstrate that retino-raphe signals modulate DRN serotonergic tone and affective behavior.
Persistent Identifierhttp://hdl.handle.net/10722/184458
ISSN
2015 Impact Factor: 6.399
2015 SCImago Journal Rankings: 3.517
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRen, Cen_US
dc.contributor.authorLuan, Len_US
dc.contributor.authorLau, WMen_US
dc.contributor.authorHuang, Xen_US
dc.contributor.authorYang, Jen_US
dc.contributor.authorZhou, Yen_US
dc.contributor.authorWu, Xen_US
dc.contributor.authorGao, Jen_US
dc.contributor.authorPickard, GEen_US
dc.contributor.authorSo, KFen_US
dc.contributor.authorPu, Men_US
dc.date.accessioned2013-07-15T09:47:28Z-
dc.date.available2013-07-15T09:47:28Z-
dc.date.issued2013en_US
dc.identifier.citationNeuropsychopharmacology, 2013, v. 38 n. 7, p. 1163-1175en_US
dc.identifier.issn0893-133X-
dc.identifier.urihttp://hdl.handle.net/10722/184458-
dc.description.abstractLight is a powerful modulator of higher-order cognitive processes such as mood but it remains unclear which neural circuits mediate the impact of light on affective behavior. We found that light deprivation produces a depressive-like behavioral state that is reversed by activation of direct retinal signals to the serotonergic dorsal raphe nucleus (DRN) in a manner equivalent to treatment with the selective serotonin reuptake inhibitor fluoxetine. Surprisingly, the DRN-projecting retinal ganglion cells (RGCs) are indistinguishable from the classic alpha/Y-like RGC type that contributes to image-forming visual pathways. Silencing RGC firing or specific immunotoxin ablation of DRN-projecting RGCs increased depressive-like behavior and reduced serotonin levels in the DRN. Serotonin has a key role in the pathophysiology of depression, and these results demonstrate that retino-raphe signals modulate DRN serotonergic tone and affective behavior.-
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.neuropsychopharmacology.org-
dc.relation.ispartofNeuropsychopharmacologyen_US
dc.titleDirect retino-raphe projection alters serotonergic tone and affective behavioren_US
dc.typeArticleen_US
dc.identifier.emailLau, WM: bwmlau@hku.hken_US
dc.identifier.emailYang, J: jianyang@hkucc.hku.hken_US
dc.identifier.emailSo, KF: hrmaskf@hku.hken_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1038/npp.2013.35-
dc.identifier.pmid23370156-
dc.identifier.pmcidPMC3656380-
dc.identifier.scopuseid_2-s2.0-84878563273-
dc.identifier.hkuros215680en_US
dc.identifier.volume38en_US
dc.identifier.issue7-
dc.identifier.spage1163en_US
dc.identifier.epage1175en_US
dc.identifier.isiWOS:000319120000003-
dc.publisher.placeUnited Kingdom-

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