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Article: Global flash multifocal electroretinogram: early detection of local functional changes and its correlations with optical coherence tomography and visual field tests in diabetic eyes

TitleGlobal flash multifocal electroretinogram: early detection of local functional changes and its correlations with optical coherence tomography and visual field tests in diabetic eyes
Authors
Issue Date2012
PublisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0012-4486
Citation
Documenta Ophthalmologica, 2012, v. 125 n. 2, p. 123-135 How to Cite?
AbstractPurpose To investigate the correlations of the global flash multifocal electroretinogram (MOFO mfERG) with common clinical visual assessments-Humphrey perimetry and Stratus circumpapillary retinal nerve fiber layer (RNFL) thickness measurement in type II diabetic patients. Methods Forty-two diabetic patients participated in the study: Ten were free from diabetic retinopathy (DR), while the remainder suffered from mild to moderate nonproliferative diabetic retinopathy. Fourteen age-matched controls were recruited for comparison. MOFO mfERG measurements were made under high-and lowcontrast conditions. Humphrey central 30-2 perimetry and Stratus OCT circumpapillary RNFL thickness measurements were also performed. Correlations between local values of implicit time and amplitude of the mfERG components [direct component (DC) and induced component (IC)], and perimetric sensitivity and RNFL thickness were evaluated by mapping the localized responses for the three subject groups. Results MOFO mfERG was superior to perimetry and RNFL assessments in showing differences between the diabetic groups (with and without DR) and the controls. All the MOFO mfERG amplitudes (except IC amplitude at high contrast) correlated better with perimetry findings (Pearson's r ranged from 0.23 to 0.36, p\0.01) than did the mfERG implicit time at both high and low contrasts across all subject groups. No consistent correlation was found between the mfERG and RNFL assessments for any group or contrast conditions. The responses of the local MOFO mfERG correlated with local perimetric sensitivity but not with RNFL thickness. Conclusion Early functional changes in the diabetic retina seem to occur before morphological changes in the RNFL. © Springer-Verlag 2012.
Persistent Identifierhttp://hdl.handle.net/10722/184325
ISSN
2015 Impact Factor: 1.444
2015 SCImago Journal Rankings: 1.153
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLung, JCYen_US
dc.contributor.authorSwann, PGen_US
dc.contributor.authorWong, DSHen_US
dc.contributor.authorChan, HHLen_US
dc.date.accessioned2013-07-10T06:24:38Z-
dc.date.available2013-07-10T06:24:38Z-
dc.date.issued2012en_US
dc.identifier.citationDocumenta Ophthalmologica, 2012, v. 125 n. 2, p. 123-135en_US
dc.identifier.issn0012-4486en_US
dc.identifier.urihttp://hdl.handle.net/10722/184325-
dc.description.abstractPurpose To investigate the correlations of the global flash multifocal electroretinogram (MOFO mfERG) with common clinical visual assessments-Humphrey perimetry and Stratus circumpapillary retinal nerve fiber layer (RNFL) thickness measurement in type II diabetic patients. Methods Forty-two diabetic patients participated in the study: Ten were free from diabetic retinopathy (DR), while the remainder suffered from mild to moderate nonproliferative diabetic retinopathy. Fourteen age-matched controls were recruited for comparison. MOFO mfERG measurements were made under high-and lowcontrast conditions. Humphrey central 30-2 perimetry and Stratus OCT circumpapillary RNFL thickness measurements were also performed. Correlations between local values of implicit time and amplitude of the mfERG components [direct component (DC) and induced component (IC)], and perimetric sensitivity and RNFL thickness were evaluated by mapping the localized responses for the three subject groups. Results MOFO mfERG was superior to perimetry and RNFL assessments in showing differences between the diabetic groups (with and without DR) and the controls. All the MOFO mfERG amplitudes (except IC amplitude at high contrast) correlated better with perimetry findings (Pearson's r ranged from 0.23 to 0.36, p\0.01) than did the mfERG implicit time at both high and low contrasts across all subject groups. No consistent correlation was found between the mfERG and RNFL assessments for any group or contrast conditions. The responses of the local MOFO mfERG correlated with local perimetric sensitivity but not with RNFL thickness. Conclusion Early functional changes in the diabetic retina seem to occur before morphological changes in the RNFL. © Springer-Verlag 2012.en_US
dc.languageengen_US
dc.publisherSpringer Verlag Dordrecht. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0012-4486en_US
dc.relation.ispartofDocumenta Ophthalmologicaen_US
dc.subject.meshDiabetic Retinopathy - Diagnosis - Physiopathologyen_US
dc.subject.meshEarly Diagnosisen_US
dc.subject.meshElectroretinography - Methodsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRetinal Ganglion Cells - Physiologyen_US
dc.subject.meshTomography, Optical Coherence - Methodsen_US
dc.subject.meshVisual Field Testsen_US
dc.subject.meshVisual Fieldsen_US
dc.titleGlobal flash multifocal electroretinogram: early detection of local functional changes and its correlations with optical coherence tomography and visual field tests in diabetic eyesen_US
dc.typeArticleen_US
dc.identifier.emailWong, DSH: shdwong@hkucc.hku.hken_US
dc.identifier.authorityWong, DSH=rp00516en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s10633-012-9343-0en_US
dc.identifier.pmid22828871-
dc.identifier.scopuseid_2-s2.0-84866551708en_US
dc.identifier.hkuros226555-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84866551708&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume125en_US
dc.identifier.issue2en_US
dc.identifier.spage123en_US
dc.identifier.epage135en_US
dc.identifier.isiWOS:000308367700004-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridLung, JCY=24385392700en_US
dc.identifier.scopusauthoridSwann, PG=7005273546en_US
dc.identifier.scopusauthoridWong, DSH=7401536078en_US
dc.identifier.scopusauthoridChan, HHL=24774420300en_US
dc.customcontrol.immutablejt 131029-

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