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Article: A new policy for prenatal screening and diagnosis of Down syndrome for pregnant women with advanced maternal age in a public hospital

TitleA new policy for prenatal screening and diagnosis of Down syndrome for pregnant women with advanced maternal age in a public hospital
Authors
Issue Date2010
PublisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/14767058.asp
Citation
Journal Of Maternal-Fetal And Neonatal Medicine, 2010, v. 23 n. 8, p. 914-919 How to Cite?
AbstractObjective. Before April 2006, women with singleton pregnancy and advanced maternal age (AMA, 35 years and older) were offered either direct invasive tests or a variety of screening tests for Down syndrome (DS) with routine anomaly scan at 1820 weeks. After April 2006, to reduce procedure-related fetal loss, invasive test was performed only for positive screening result or the presence of major fetal anomaly on ultrasound. We reviewed our 2-year experience after the policy change. Methods. Two-year data after policy change were compared to the 1-year historic control before policy change. Results. A total of 2257 eligible women were counselled in the 2 years after policy change. The uptake of screening was 96.7%. The overall detection rate for DS was 90% (18/20) at a false positive rate of 10.9%. The number of invasive tests performed to diagnose one case of DS was reduced 7-fold from 97 to 13. Conclusions. The number of direct invasive tests was markedly reduced. With effective DS screening policy, it is possible to do away with direct invasive testing for the majority of women with AMA. © 2010 Informa UK Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/184213
ISSN
2015 Impact Factor: 1.674
2015 SCImago Journal Rankings: 0.810
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLo, TKen_US
dc.contributor.authorLai, FKen_US
dc.contributor.authorLeung, WCen_US
dc.contributor.authorLau, WLen_US
dc.contributor.authorTang, LCHen_US
dc.contributor.authorChin, RKHen_US
dc.date.accessioned2013-06-25T03:01:26Z-
dc.date.available2013-06-25T03:01:26Z-
dc.date.issued2010en_US
dc.identifier.citationJournal Of Maternal-Fetal And Neonatal Medicine, 2010, v. 23 n. 8, p. 914-919en_US
dc.identifier.issn1476-7058en_US
dc.identifier.urihttp://hdl.handle.net/10722/184213-
dc.description.abstractObjective. Before April 2006, women with singleton pregnancy and advanced maternal age (AMA, 35 years and older) were offered either direct invasive tests or a variety of screening tests for Down syndrome (DS) with routine anomaly scan at 1820 weeks. After April 2006, to reduce procedure-related fetal loss, invasive test was performed only for positive screening result or the presence of major fetal anomaly on ultrasound. We reviewed our 2-year experience after the policy change. Methods. Two-year data after policy change were compared to the 1-year historic control before policy change. Results. A total of 2257 eligible women were counselled in the 2 years after policy change. The uptake of screening was 96.7%. The overall detection rate for DS was 90% (18/20) at a false positive rate of 10.9%. The number of invasive tests performed to diagnose one case of DS was reduced 7-fold from 97 to 13. Conclusions. The number of direct invasive tests was markedly reduced. With effective DS screening policy, it is possible to do away with direct invasive testing for the majority of women with AMA. © 2010 Informa UK Ltd.en_US
dc.languageengen_US
dc.publisherInforma Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/14767058.aspen_US
dc.relation.ispartofJournal of Maternal-Fetal and Neonatal Medicineen_US
dc.subject.meshAdulten_US
dc.subject.meshDown Syndrome - Diagnosisen_US
dc.subject.meshFemaleen_US
dc.subject.meshHospitals, Public - Statistics & Numerical Dataen_US
dc.subject.meshHumansen_US
dc.subject.meshMass Screening - Statistics & Numerical Dataen_US
dc.subject.meshMaternal Ageen_US
dc.subject.meshPractice Guidelines As Topicen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPrenatal Diagnosis - Statistics & Numerical Dataen_US
dc.titleA new policy for prenatal screening and diagnosis of Down syndrome for pregnant women with advanced maternal age in a public hospitalen_US
dc.typeArticleen_US
dc.identifier.emailTang, LCH: lchtang@hku.hken_US
dc.identifier.authorityTang, LCH=rp01756en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.3109/14767050903370327en_US
dc.identifier.pmid19883260-
dc.identifier.scopuseid_2-s2.0-77954735354en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77954735354&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume23en_US
dc.identifier.issue8en_US
dc.identifier.spage914en_US
dc.identifier.epage919en_US
dc.identifier.isiWOS:000280592200023-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLo, TK=7203076032en_US
dc.identifier.scopusauthoridLai, FK=24461966400en_US
dc.identifier.scopusauthoridLeung, WC=7201504435en_US
dc.identifier.scopusauthoridLau, WL=12142218500en_US
dc.identifier.scopusauthoridTang, LCH=7402081111en_US
dc.identifier.scopusauthoridChin, RKH=24358899900en_US

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