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Article: Oral misoprostol for induction of labor in prelabor rupture of membranes (PROM) at term: A randomized control trial

TitleOral misoprostol for induction of labor in prelabor rupture of membranes (PROM) at term: A randomized control trial
Authors
Issue Date2006
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0412
Citation
Acta Obstetricia Et Gynecologica Scandinavica, 2006, v. 85 n. 9, p. 1128-1133 How to Cite?
AbstractObjective. To compare the efficacy of two different dosages of oral misoprostol (50 and 100μg) with control, in medical induction of labor for patients with prelabor rupture of membranes (PROM) at term. Methods. One hundred women with PROM at term were randomized to receive placebo (vitamin B6 50 mg, control), 50μg (treatment group 1), or 100 μg (treatment group 2) of oral misoprostol every 4 h to a maximum of six doses. The main outcome measures included time interval from onset of PROM to delivery, duration of first stage of labor, and occurrence of vaginal delivery within 24 h from PROM. Results. The time intervals from PROM to delivery were significantly reduced in both treatment groups compared to control (control, 25.1±10.5 h; treatment group 1, 14.5±6.2 h; and treatment group 2, 13.0±6.1 h, p <0.0001 for both). The duration of the first stage of labor was significantly shortened only in treatment group 2 compared to control (3.3±2.5 versus 6.2±3.4 h, p = 0.01). Of those who delivered vaginally (93% in treatment group 1 and 97% in treatment group 2), significantly more women delivered within 24 h of PROM in the treatment group compared to the control group (50%, p <0.05). There were no statistically significant differences in neonatal or maternal outcomes amongst the three groups. Conclusions. Oral misoprostol 50 μg every 4 h is safe, cheap, and as effective as 100 μg in reducing the PROM to delivery time interval and labor duration in primiparous women. The same effect is not observed in a multiparous group. © 2006 Taylor & Francis.
Persistent Identifierhttp://hdl.handle.net/10722/184207
ISSN
2015 Impact Factor: 2.191
2015 SCImago Journal Rankings: 1.197
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, PCen_US
dc.contributor.authorYeo, ELKen_US
dc.contributor.authorWong, KSen_US
dc.contributor.authorTang, LCHen_US
dc.date.accessioned2013-06-25T03:01:22Z-
dc.date.available2013-06-25T03:01:22Z-
dc.date.issued2006en_US
dc.identifier.citationActa Obstetricia Et Gynecologica Scandinavica, 2006, v. 85 n. 9, p. 1128-1133en_US
dc.identifier.issn0001-6349en_US
dc.identifier.urihttp://hdl.handle.net/10722/184207-
dc.description.abstractObjective. To compare the efficacy of two different dosages of oral misoprostol (50 and 100μg) with control, in medical induction of labor for patients with prelabor rupture of membranes (PROM) at term. Methods. One hundred women with PROM at term were randomized to receive placebo (vitamin B6 50 mg, control), 50μg (treatment group 1), or 100 μg (treatment group 2) of oral misoprostol every 4 h to a maximum of six doses. The main outcome measures included time interval from onset of PROM to delivery, duration of first stage of labor, and occurrence of vaginal delivery within 24 h from PROM. Results. The time intervals from PROM to delivery were significantly reduced in both treatment groups compared to control (control, 25.1±10.5 h; treatment group 1, 14.5±6.2 h; and treatment group 2, 13.0±6.1 h, p <0.0001 for both). The duration of the first stage of labor was significantly shortened only in treatment group 2 compared to control (3.3±2.5 versus 6.2±3.4 h, p = 0.01). Of those who delivered vaginally (93% in treatment group 1 and 97% in treatment group 2), significantly more women delivered within 24 h of PROM in the treatment group compared to the control group (50%, p <0.05). There were no statistically significant differences in neonatal or maternal outcomes amongst the three groups. Conclusions. Oral misoprostol 50 μg every 4 h is safe, cheap, and as effective as 100 μg in reducing the PROM to delivery time interval and labor duration in primiparous women. The same effect is not observed in a multiparous group. © 2006 Taylor & Francis.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0412en_US
dc.relation.ispartofActa Obstetricia et Gynecologica Scandinavicaen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAdulten_US
dc.subject.meshDelivery, Obstetricen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshFemaleen_US
dc.subject.meshFetal Membranes, Premature Rupture - Drug Therapy - Therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshLabor Stage, First - Drug Effects - Physiologyen_US
dc.subject.meshLabor, Induced - Methodsen_US
dc.subject.meshMisoprostol - Administration & Dosage - Therapeutic Useen_US
dc.subject.meshOxytocics - Administration & Dosage - Therapeutic Useen_US
dc.subject.meshParityen_US
dc.subject.meshPlacebosen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Outcomeen_US
dc.subject.meshTime Factorsen_US
dc.titleOral misoprostol for induction of labor in prelabor rupture of membranes (PROM) at term: A randomized control trialen_US
dc.typeArticleen_US
dc.identifier.emailTang, LCH: lchtang@hku.hken_US
dc.identifier.authorityTang, LCH=rp01756en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1080/00016340600589636en_US
dc.identifier.pmid16929421-
dc.identifier.scopuseid_2-s2.0-33747777789en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33747777789&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume85en_US
dc.identifier.issue9en_US
dc.identifier.spage1128en_US
dc.identifier.epage1133en_US
dc.identifier.isiWOS:000240285000016-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridCheung, PC=36921275000en_US
dc.identifier.scopusauthoridYeo, ELK=8139882600en_US
dc.identifier.scopusauthoridWong, KS=36341790700en_US
dc.identifier.scopusauthoridTang, LCH=7402081111en_US

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