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Article: Hepatic veno-occlusive disease after hematopoietic stem cell transplantation: Prophylaxis and treatment controversies

TitleHepatic veno-occlusive disease after hematopoietic stem cell transplantation: Prophylaxis and treatment controversies
Authors
KeywordsHepatic veno-occlusive disease
Hematopoietic stem cell transplantation
Prophylaxis
Treatment
Randomized controlled trial
Issue Date2012
PublisherBaishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/2218-6204/index.htm
Citation
World Journal of Transplantation, 2012, v. 2 n. 2, p. 27-34 How to Cite?
AbstractHepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome, is a major complication of hematopoietic stem cell transplantation and it carries a high mortality. Prophylaxis for hepatic VOD is commonly given to transplant recipients from the start of conditioning through the early weeks of transplant. However, high quality evidence from randomized controlled trials is scarce with small sample sizes and the trials yielded conflicting results. Although various treatment options for hepatic VOD are available, most have not undergone stringent evaluation with randomized controlled trial and therefore it remains uncertain which treatment offers real benefit. It remains controversial whether VOD prophylaxis should be given, which prophylactic therapy should be given, who should receive prophylaxis, and what treatment should be offered once VOD is established.
Persistent Identifierhttp://hdl.handle.net/10722/183772
ISSN

 

DC FieldValueLanguage
dc.contributor.authorCheuk, DKLen_US
dc.date.accessioned2013-06-18T04:13:44Z-
dc.date.available2013-06-18T04:13:44Z-
dc.date.issued2012en_US
dc.identifier.citationWorld Journal of Transplantation, 2012, v. 2 n. 2, p. 27-34en_US
dc.identifier.issn2218-6204-
dc.identifier.urihttp://hdl.handle.net/10722/183772-
dc.description.abstractHepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome, is a major complication of hematopoietic stem cell transplantation and it carries a high mortality. Prophylaxis for hepatic VOD is commonly given to transplant recipients from the start of conditioning through the early weeks of transplant. However, high quality evidence from randomized controlled trials is scarce with small sample sizes and the trials yielded conflicting results. Although various treatment options for hepatic VOD are available, most have not undergone stringent evaluation with randomized controlled trial and therefore it remains uncertain which treatment offers real benefit. It remains controversial whether VOD prophylaxis should be given, which prophylactic therapy should be given, who should receive prophylaxis, and what treatment should be offered once VOD is established.-
dc.languageengen_US
dc.publisherBaishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/2218-6204/index.htm-
dc.relation.ispartofWorld Journal of Transplantationen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectHepatic veno-occlusive disease-
dc.subjectHematopoietic stem cell transplantation-
dc.subjectProphylaxis-
dc.subjectTreatment-
dc.subjectRandomized controlled trial-
dc.titleHepatic veno-occlusive disease after hematopoietic stem cell transplantation: Prophylaxis and treatment controversiesen_US
dc.typeArticleen_US
dc.identifier.emailCheuk, KLD: klcheuk@hkucc.hku.hken_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.5500/wjt.v2.i2.27-
dc.identifier.hkuros214771en_US
dc.identifier.volume2en_US
dc.identifier.issue2en_US
dc.identifier.spage27en_US
dc.identifier.epage34en_US
dc.publisher.placeHong Kong-

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