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Article: A CD90+ Tumor-Initiating Cell Population with an Aggressive Signature and Metastatic Capacity in Esophageal Cancer

TitleA CD90+ Tumor-Initiating Cell Population with an Aggressive Signature and Metastatic Capacity in Esophageal Cancer
Authors
Issue Date2013
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Cancer Research, 2013, v. 73 n. 7, p. 2322-2332 How to Cite?
AbstractTumor-initiating cells (TIC), also known as cancer stem cells, are regarded widely as a specific subpopulation of cells needed for cancer initiation and progression. TICs have yet to be identified in esophageal tumors that have an increasing incidence in developed countries. Here, we report a CD90 cell population found in esophageal squamous cell carcinoma (ESCC), which is endowed with stem cell-like properties and high tumorigenic and metastatic potential. mRNA profiling of these cells suggested pathways through which they drive tumor growth and metastasis, with deregulation of an Ets-1/MMP signaling pathway and epithelial-mesenchymal transition figuring prominently. These cells possessed higher self-renewal activity and were sufficient for tumor growth, differentiation, metastasis, and chemotherapeutic resistance. CD90 TICs were isolated and characterized from ESCC clinical specimens as well as ESCC cell lines. In freshly resected clinical specimens, they represented a rare cell population, the levels of which correlated with strong family histories and lymph node metastasis. Our results prompt further study of this CD90+ population of esophageal TICs as potential therapeutic targets. © 2012 American Association for Cancer Research.
Persistent Identifierhttp://hdl.handle.net/10722/183682
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTang, KH-
dc.contributor.authorDai, YD-
dc.contributor.authorTong, M-
dc.contributor.authorChan, YP-
dc.contributor.authorKwan, PS-
dc.contributor.authorFu, L-
dc.contributor.authorQin, YR-
dc.contributor.authorTsao, GSW-
dc.contributor.authorLung, HL-
dc.contributor.authorLung, ML-
dc.contributor.authorTong, DKH-
dc.contributor.authorLaw, SYK-
dc.contributor.authorChan, KW-
dc.contributor.authorMa, SKY-
dc.contributor.authorGuan, X-
dc.date.accessioned2013-06-18T04:07:20Z-
dc.date.available2013-06-18T04:07:20Z-
dc.date.issued2013-
dc.identifier.citationCancer Research, 2013, v. 73 n. 7, p. 2322-2332-
dc.identifier.issn0008-5472-
dc.identifier.urihttp://hdl.handle.net/10722/183682-
dc.description.abstractTumor-initiating cells (TIC), also known as cancer stem cells, are regarded widely as a specific subpopulation of cells needed for cancer initiation and progression. TICs have yet to be identified in esophageal tumors that have an increasing incidence in developed countries. Here, we report a CD90 cell population found in esophageal squamous cell carcinoma (ESCC), which is endowed with stem cell-like properties and high tumorigenic and metastatic potential. mRNA profiling of these cells suggested pathways through which they drive tumor growth and metastasis, with deregulation of an Ets-1/MMP signaling pathway and epithelial-mesenchymal transition figuring prominently. These cells possessed higher self-renewal activity and were sufficient for tumor growth, differentiation, metastasis, and chemotherapeutic resistance. CD90 TICs were isolated and characterized from ESCC clinical specimens as well as ESCC cell lines. In freshly resected clinical specimens, they represented a rare cell population, the levels of which correlated with strong family histories and lymph node metastasis. Our results prompt further study of this CD90+ population of esophageal TICs as potential therapeutic targets. © 2012 American Association for Cancer Research.-
dc.languageeng-
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/-
dc.relation.ispartofCancer Research-
dc.titleA CD90+ Tumor-Initiating Cell Population with an Aggressive Signature and Metastatic Capacity in Esophageal Cancer-
dc.typeArticle-
dc.identifier.emailTang, KH: h0422624@hkusua.hku.hk-
dc.identifier.emailChan, YP: bchanyp@hkucc.hku.hk-
dc.identifier.emailKwan, PS: kwanps@hku.hk-
dc.identifier.emailFu, L: gracefu@graduate.hku.hk-
dc.identifier.emailTsao, GSW: gswtsao@hku.hk-
dc.identifier.emailLung, HL: hllung2@hku.hk-
dc.identifier.emailLung, ML: mlilung@hku.hk-
dc.identifier.emailTong, DKH: esodtong@hku.hk-
dc.identifier.emailLaw, SYK: slaw@hku.hk-
dc.identifier.emailChan, KW: hrmtckw@hku.hk-
dc.identifier.emailMa, SKY: stefma@hku.hk-
dc.identifier.emailGuan, X: xyguan@hkucc.hku.hk-
dc.identifier.authorityFu, L=rp01435-
dc.identifier.authorityTsao, GSW=rp00399-
dc.identifier.authorityLung, HL=rp00299-
dc.identifier.authorityLung, ML=rp00300-
dc.identifier.authorityLaw, SYK=rp00437-
dc.identifier.authorityChan, KW=rp00330-
dc.identifier.authorityMa, SKY=rp00506-
dc.identifier.authorityGuan, X=rp00454-
dc.identifier.doi10.1158/0008-5472.CAN-12-2991-
dc.identifier.pmid23382045-
dc.identifier.scopuseid_2-s2.0-84875981178-
dc.identifier.hkuros214431-
dc.identifier.volume73-
dc.identifier.issue7-
dc.identifier.spage2322-
dc.identifier.epage2332-
dc.identifier.isiWOS:000316995600029-
dc.publisher.placeUnited States-

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