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Article: Prevalence and risk factors of diabetic retinopathy in migrant Indians in an urbanized society in Asia: The Singapore Indian eye study

TitlePrevalence and risk factors of diabetic retinopathy in migrant Indians in an urbanized society in Asia: The Singapore Indian eye study
Authors
Issue Date2012
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ophtha
Citation
Ophthalmology, 2012, v. 119 n. 10, p. 2119-2124 How to Cite?
AbstractPurpose: To describe the prevalence of and risk factors for diabetic retinopathy (DR) in Indian persons living in a newly urbanized society in Asia. Design: Population-based study. Participants: Ethnic Indians aged <40 years living in Singapore. Methods: The Singapore Indian Eye Study was conducted between 2007 and 2009. All participants underwent an extensive ophthalmic examination, including retinal photographs obtained after pupil dilation. These images were graded for the presence and severity of DR using the modified Airlie House classification system. Diabetes was defined as hemoglobin A1c level of <6.5%, use of diabetic medication, or a physician diagnosis of diabetes. Risk factors were measured using questionnaires, clinical assessments, or laboratory tests. Main Outcome Measures: Any DR, diabetic macular edema (DME), or vision-threatening DR (VTDR). Results: Among the 3400 participants, the age-standardized prevalence was 33.6% (95% confidence interval [CI], 31.4-35.8) for diabetes and 10.5% (95% CI, 9.3-11.8) for DR. Among those with diabetes only, the age-standardized prevalence was 30.4% (95% CI, 26.5-34.8) for any DR, 7.2% (95% CI, 5.3-9.7) for DME, and 7.1% (95% CI, 5.4-9.5) for VTDR. In multivariate analysis, independent risk factors for any DR were younger age (odds ratio [OR], 0.98; 95% CI, 0.96-1.00, per year increase), longer diabetes duration (OR, 1.09; 95% CI, 1.07-1.11 per year increase), higher hemoglobin A1c (OR, 1.23; 95% CI, 1.13-1.34 per percent increase), higher systolic blood pressure (OR, 1.01; 95% CI, 1.00-1.02 per 1-mmHg increase), lower diastolic blood pressure (OR, 0.97; 95% CI, 0.96-0.99 per 1-mmHg increase), history of previous stroke (OR, 2.16; 95% CI, 1.12-4.16), and insulin treatment (OR, 2.99; 95% CI, 1.84-4.87). Similar independent risk factors, except for blood pressure, were found for VTDR. Additionally, persons with lower income and living in smaller houses were associated with VTDR. Conclusions: One in 3 migrant Indians living in newly urbanized Asian societies have diabetes and 1 in 10 has DR. This is similar to rates reported in Western populations and significantly higher than those reported in India. Financial Disclosure(s): The authors have no proprietary or commercial interest in any of the materials discussed in this article. © 2012 American Academy of Ophthalmology.
Persistent Identifierhttp://hdl.handle.net/10722/183623
ISSN
2015 Impact Factor: 6.75
2015 SCImago Journal Rankings: 4.745
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZheng, Yen_US
dc.contributor.authorLamoureux, ELen_US
dc.contributor.authorLavanya, Ren_US
dc.contributor.authorWu, Ren_US
dc.contributor.authorIkram, MKen_US
dc.contributor.authorWang, JJen_US
dc.contributor.authorMitchell, Pen_US
dc.contributor.authorCheung, Nen_US
dc.contributor.authorAung, Ten_US
dc.contributor.authorSaw, SMen_US
dc.contributor.authorWong, TYen_US
dc.date.accessioned2013-05-28T06:15:29Z-
dc.date.available2013-05-28T06:15:29Z-
dc.date.issued2012en_US
dc.identifier.citationOphthalmology, 2012, v. 119 n. 10, p. 2119-2124en_US
dc.identifier.issn0161-6420en_US
dc.identifier.urihttp://hdl.handle.net/10722/183623-
dc.description.abstractPurpose: To describe the prevalence of and risk factors for diabetic retinopathy (DR) in Indian persons living in a newly urbanized society in Asia. Design: Population-based study. Participants: Ethnic Indians aged <40 years living in Singapore. Methods: The Singapore Indian Eye Study was conducted between 2007 and 2009. All participants underwent an extensive ophthalmic examination, including retinal photographs obtained after pupil dilation. These images were graded for the presence and severity of DR using the modified Airlie House classification system. Diabetes was defined as hemoglobin A1c level of <6.5%, use of diabetic medication, or a physician diagnosis of diabetes. Risk factors were measured using questionnaires, clinical assessments, or laboratory tests. Main Outcome Measures: Any DR, diabetic macular edema (DME), or vision-threatening DR (VTDR). Results: Among the 3400 participants, the age-standardized prevalence was 33.6% (95% confidence interval [CI], 31.4-35.8) for diabetes and 10.5% (95% CI, 9.3-11.8) for DR. Among those with diabetes only, the age-standardized prevalence was 30.4% (95% CI, 26.5-34.8) for any DR, 7.2% (95% CI, 5.3-9.7) for DME, and 7.1% (95% CI, 5.4-9.5) for VTDR. In multivariate analysis, independent risk factors for any DR were younger age (odds ratio [OR], 0.98; 95% CI, 0.96-1.00, per year increase), longer diabetes duration (OR, 1.09; 95% CI, 1.07-1.11 per year increase), higher hemoglobin A1c (OR, 1.23; 95% CI, 1.13-1.34 per percent increase), higher systolic blood pressure (OR, 1.01; 95% CI, 1.00-1.02 per 1-mmHg increase), lower diastolic blood pressure (OR, 0.97; 95% CI, 0.96-0.99 per 1-mmHg increase), history of previous stroke (OR, 2.16; 95% CI, 1.12-4.16), and insulin treatment (OR, 2.99; 95% CI, 1.84-4.87). Similar independent risk factors, except for blood pressure, were found for VTDR. Additionally, persons with lower income and living in smaller houses were associated with VTDR. Conclusions: One in 3 migrant Indians living in newly urbanized Asian societies have diabetes and 1 in 10 has DR. This is similar to rates reported in Western populations and significantly higher than those reported in India. Financial Disclosure(s): The authors have no proprietary or commercial interest in any of the materials discussed in this article. © 2012 American Academy of Ophthalmology.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ophthaen_US
dc.relation.ispartofOphthalmologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshBlood Pressureen_US
dc.subject.meshDiabetes Mellitus, Type 1 - Ethnologyen_US
dc.subject.meshDiabetes Mellitus, Type 2 - Ethnologyen_US
dc.subject.meshDiabetic Retinopathy - Diagnosis - Ethnologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHemoglobin A, Glycosylated - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshIndia - Ethnologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPrevalenceen_US
dc.subject.meshQuestionnairesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSingapore - Epidemiologyen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTransients And Migrants - Statistics & Numerical Dataen_US
dc.subject.meshUrban Population - Statistics & Numerical Dataen_US
dc.titlePrevalence and risk factors of diabetic retinopathy in migrant Indians in an urbanized society in Asia: The Singapore Indian eye studyen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ophtha.2012.04.027en_US
dc.identifier.pmid22709419-
dc.identifier.scopuseid_2-s2.0-84867097509en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84867097509&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume119en_US
dc.identifier.issue10en_US
dc.identifier.spage2119en_US
dc.identifier.epage2124en_US
dc.identifier.isiWOS:000310581900027-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridZheng, Y=16240506800en_US
dc.identifier.scopusauthoridLamoureux, EL=7003839871en_US
dc.identifier.scopusauthoridLavanya, R=23492602100en_US
dc.identifier.scopusauthoridWu, R=7402945054en_US
dc.identifier.scopusauthoridIkram, MK=55196332300en_US
dc.identifier.scopusauthoridWang, JJ=35231432000en_US
dc.identifier.scopusauthoridMitchell, P=7402933815en_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridAung, T=26643141900en_US
dc.identifier.scopusauthoridSaw, SM=7006402006en_US
dc.identifier.scopusauthoridWong, TY=7403531208en_US

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