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Article: Retinal vascular geometry predicts incident renal dysfunction in young people with type 1 diabetes

TitleRetinal vascular geometry predicts incident renal dysfunction in young people with type 1 diabetes
Authors
Issue Date2012
PublisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/
Citation
Diabetes Care, 2012, v. 35 n. 3, p. 599-604 How to Cite?
AbstractOBJECTIVE - To examine the relationship between retinal vascular geometry parameters and development of incident renal dysfunction in young people with type 1 diabetes. RESEARCH DESIGN AND METHODS - This was a prospective cohort study of 511 adolescents with type 1 diabetes of at least 2 years duration, with normal albumin excretion rate (AER) and no retinopathy at baseline while attending an Australian tertiary-care hospital. AER was quantified using three overnight, timed urine specimen collections and early renal dysfunction was defined as AER >7.5 μg/min. Retinal vascular geometry (including length-to-diameter ratio [LDR] and simple tortuosity [ST]) was quantified from baseline retinal photographs. Generalized estimating equations were used to examine the relationship between incident renal dysfunction and baseline venular LDR and ST, adjusting for age, diabetes duration, glycated hemoglobin (A1C), blood pressure (BP), BMI, and cholesterol. RESULTS - Diabetes duration at baseline was 4.8 (IQR 3.3-7.5) years. After amedian 3.7 (2.3-5.7) years follow-up, 34% of participants developed incident renal dysfunction. In multivariate analysis, higher retinal venular LDR (odds ratio 1.7, 95% CI 1.2-2.4; quartile 4 vs. 1-3) and lower venular ST (1.6, 1.1-2.2; quartile 1 vs. 2-4) predicted incident renal dysfunction. CONCLUSIONS - Retinal venular geometry independently predicted incident renal dysfunction in young people with type 1 diabetes. These noninvasive retinal measures may help to elucidate early mechanistic pathways for microvascular complications. Retinal venular geometry may be a useful tool to identify individuals at high risk of renal disease early in the course of diabetes. © 2012 by the American Diabetes Association.
Persistent Identifierhttp://hdl.handle.net/10722/183618
ISSN
2015 Impact Factor: 8.934
2015 SCImago Journal Rankings: 5.827
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBenitezAguirre, PZen_US
dc.contributor.authorSasongko, MBen_US
dc.contributor.authorCraig, MEen_US
dc.contributor.authorJenkins, AJen_US
dc.contributor.authorCusumano, Jen_US
dc.contributor.authorCheung, Nen_US
dc.contributor.authorWong, TYen_US
dc.contributor.authorDonaghue, KCen_US
dc.date.accessioned2013-05-28T06:15:27Z-
dc.date.available2013-05-28T06:15:27Z-
dc.date.issued2012en_US
dc.identifier.citationDiabetes Care, 2012, v. 35 n. 3, p. 599-604en_US
dc.identifier.issn0149-5992en_US
dc.identifier.urihttp://hdl.handle.net/10722/183618-
dc.description.abstractOBJECTIVE - To examine the relationship between retinal vascular geometry parameters and development of incident renal dysfunction in young people with type 1 diabetes. RESEARCH DESIGN AND METHODS - This was a prospective cohort study of 511 adolescents with type 1 diabetes of at least 2 years duration, with normal albumin excretion rate (AER) and no retinopathy at baseline while attending an Australian tertiary-care hospital. AER was quantified using three overnight, timed urine specimen collections and early renal dysfunction was defined as AER >7.5 μg/min. Retinal vascular geometry (including length-to-diameter ratio [LDR] and simple tortuosity [ST]) was quantified from baseline retinal photographs. Generalized estimating equations were used to examine the relationship between incident renal dysfunction and baseline venular LDR and ST, adjusting for age, diabetes duration, glycated hemoglobin (A1C), blood pressure (BP), BMI, and cholesterol. RESULTS - Diabetes duration at baseline was 4.8 (IQR 3.3-7.5) years. After amedian 3.7 (2.3-5.7) years follow-up, 34% of participants developed incident renal dysfunction. In multivariate analysis, higher retinal venular LDR (odds ratio 1.7, 95% CI 1.2-2.4; quartile 4 vs. 1-3) and lower venular ST (1.6, 1.1-2.2; quartile 1 vs. 2-4) predicted incident renal dysfunction. CONCLUSIONS - Retinal venular geometry independently predicted incident renal dysfunction in young people with type 1 diabetes. These noninvasive retinal measures may help to elucidate early mechanistic pathways for microvascular complications. Retinal venular geometry may be a useful tool to identify individuals at high risk of renal disease early in the course of diabetes. © 2012 by the American Diabetes Association.en_US
dc.languageengen_US
dc.publisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/en_US
dc.relation.ispartofDiabetes Careen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshChilden_US
dc.subject.meshDiabetes Mellitus, Type 1 - Complications - Epidemiologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshKidney Diseases - Epidemiology - Etiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMultivariate Analysisen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRetinal Vessels - Abnormalitiesen_US
dc.subject.meshYoung Adulten_US
dc.titleRetinal vascular geometry predicts incident renal dysfunction in young people with type 1 diabetesen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.2337/dc11-1177en_US
dc.identifier.pmid22250064-
dc.identifier.pmcidPMC3322713-
dc.identifier.scopuseid_2-s2.0-84859040726en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84859040726&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume35en_US
dc.identifier.issue3en_US
dc.identifier.spage599en_US
dc.identifier.epage604en_US
dc.identifier.isiWOS:000300801400028-
dc.publisher.placeUnited Statesen_US
dc.identifier.f1000718077146-
dc.identifier.scopusauthoridBenitezAguirre, PZ=26535507200en_US
dc.identifier.scopusauthoridSasongko, MB=36100847400en_US
dc.identifier.scopusauthoridCraig, ME=7103269737en_US
dc.identifier.scopusauthoridJenkins, AJ=7202458130en_US
dc.identifier.scopusauthoridCusumano, J=8704120400en_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridWong, TY=7403531208en_US
dc.identifier.scopusauthoridDonaghue, KC=7003470857en_US

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