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Article: Are lung disease and function related to age-related macular degeneration?

TitleAre lung disease and function related to age-related macular degeneration?
Authors
Issue Date2011
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajo
Citation
American Journal Of Ophthalmology, 2011, v. 151 n. 2, p. 375-379 How to Cite?
AbstractPurpose To describe the relationship of lung disease and function with early age-related macular degeneration (AMD) in a population-based study. Design A population-based, cross-sectional study of 12 596 middle-aged participants from the Atherosclerosis Risk in Communities Study. Methods Lung function was assessed by spirometry. Physician diagnosis of asthma and lung disease was ascertained from a standardized questionnaire. AMD signs were graded from fundus photographs according to the Wisconsin grading protocol. Results Among the study population, 587 (4.7%) had early AMD, 638 (5.1%) had asthma, and 581 (4.6%) had lung disease. After adjusting for age, gender, smoking, and hypertension, each 1-L increase in predicted forced expiratory volume in 1 second (odds ratio [OR], 1.27; 95% confidence interval [CI], 0.89 to 1.80), forced vital capacity (OR, 1.18; 95% CI, 0.93 to 1.51), and peak expiratory flow rate (OR, 1.12; 95% CI, 0.95 to 1.33) were not significantly associated with early AMD. Forced expiratory volume in 1 second-to-forced vital capacity ratio (second quartile OR, 1.61; 95% CI, 0.88 to 2.93, third quartile OR, 1.65; 95% CI 0.90 to 3.03; fourth quartile OR, 1.28; 95% CI 0.68 to 2.40) was not associated significantly with early AMD. Similarly, asthma (OR, 1.06; 95% CI, 0.86 to 1.27) and other lung diseases (OR, 1.08; 95% CI, 0.90 to 1.29) were not associated with early AMD. Conclusions Our data do not support a cross-sectional association between lung disease and risk of early AMD. © 2011 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/183601
ISSN
2015 Impact Factor: 3.831
2015 SCImago Journal Rankings: 2.803
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMoorthy, Sen_US
dc.contributor.authorCheung, Nen_US
dc.contributor.authorKlein, Ren_US
dc.contributor.authorShahar, Een_US
dc.contributor.authorWong, TYen_US
dc.date.accessioned2013-05-28T06:15:15Z-
dc.date.available2013-05-28T06:15:15Z-
dc.date.issued2011en_US
dc.identifier.citationAmerican Journal Of Ophthalmology, 2011, v. 151 n. 2, p. 375-379en_US
dc.identifier.issn0002-9394en_US
dc.identifier.urihttp://hdl.handle.net/10722/183601-
dc.description.abstractPurpose To describe the relationship of lung disease and function with early age-related macular degeneration (AMD) in a population-based study. Design A population-based, cross-sectional study of 12 596 middle-aged participants from the Atherosclerosis Risk in Communities Study. Methods Lung function was assessed by spirometry. Physician diagnosis of asthma and lung disease was ascertained from a standardized questionnaire. AMD signs were graded from fundus photographs according to the Wisconsin grading protocol. Results Among the study population, 587 (4.7%) had early AMD, 638 (5.1%) had asthma, and 581 (4.6%) had lung disease. After adjusting for age, gender, smoking, and hypertension, each 1-L increase in predicted forced expiratory volume in 1 second (odds ratio [OR], 1.27; 95% confidence interval [CI], 0.89 to 1.80), forced vital capacity (OR, 1.18; 95% CI, 0.93 to 1.51), and peak expiratory flow rate (OR, 1.12; 95% CI, 0.95 to 1.33) were not significantly associated with early AMD. Forced expiratory volume in 1 second-to-forced vital capacity ratio (second quartile OR, 1.61; 95% CI, 0.88 to 2.93, third quartile OR, 1.65; 95% CI 0.90 to 3.03; fourth quartile OR, 1.28; 95% CI 0.68 to 2.40) was not associated significantly with early AMD. Similarly, asthma (OR, 1.06; 95% CI, 0.86 to 1.27) and other lung diseases (OR, 1.08; 95% CI, 0.90 to 1.29) were not associated with early AMD. Conclusions Our data do not support a cross-sectional association between lung disease and risk of early AMD. © 2011 Elsevier Inc.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ajoen_US
dc.relation.ispartofAmerican Journal of Ophthalmologyen_US
dc.subject.meshAsthma - Diagnosis - Physiopathologyen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshForced Expiratory Volumeen_US
dc.subject.meshHumansen_US
dc.subject.meshLung Diseases - Diagnosis - Physiopathologyen_US
dc.subject.meshMacular Degeneration - Diagnosis - Physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPhotographyen_US
dc.subject.meshQuestionnairesen_US
dc.subject.meshSpirometryen_US
dc.titleAre lung disease and function related to age-related macular degeneration?en_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1016/j.ajo.2010.09.001en_US
dc.identifier.pmid21168814-
dc.identifier.pmcidPMC3040408-
dc.identifier.scopuseid_2-s2.0-78751642953en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78751642953&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume151en_US
dc.identifier.issue2en_US
dc.identifier.spage375en_US
dc.identifier.epage379en_US
dc.identifier.isiWOS:000286705900027-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMoorthy, S=33567978000en_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridKlein, R=35232138400en_US
dc.identifier.scopusauthoridShahar, E=7102027459en_US
dc.identifier.scopusauthoridWong, TY=7403531208en_US

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