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Article: Smaller Birth Size is Associated With Narrower Retinal Arterioles in Early Adolescence

TitleSmaller Birth Size is Associated With Narrower Retinal Arterioles in Early Adolescence
Authors
Issue Date2010
Citation
Microcirculation, 2010, v. 17 n. 8, p. 660-668 How to Cite?
AbstractObjective: In the current study, we aimed to examine the associations of low birth weight with retinal vascular caliber and vascular fractal dimension during early adolescence.Methods: A population-based study of 12-year-old schoolchildren (2353/3144 [75.3%]) recruited from a random cluster sample of 21 schools. Birth weight, birth length and head circumference were obtained via parent report of the child's birth record. Retinal images were taken and vessel diameter and fractal dimension were quantified using validated computer-based methods.Results: After adjusting for age, sex, ethnicity, body mass index, iris color, axial length, mean arterial blood pressure, prematurity and fellow retinal vascular caliber, children in the lowest quartiles of birth weight had 2.5 μm narrower mean retinal arteriolar caliber than those in the highest quartiles (p for trend = 0.001). Associations were observed between shorter birth length and smaller head circumference with narrower retinal arterioles. Smaller head circumference was associated with decreased fractal dimension (p for trend = 0.03).Conclusions: Children with lower birth weight were more likely to have narrower retinal arterioles, while those with smaller head circumference were more likely to have reduced complexity of their retinal microvasculature. These variations in microvascular structure in adolescence could reflect a susceptibility to cardiovascular disease during adulthood, resulting from a disadvantaged growth environment in utero. © 2010 John Wiley & Sons Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/183599
ISSN
2015 Impact Factor: 2.435
2015 SCImago Journal Rankings: 1.325
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGopinath, Ben_US
dc.contributor.authorBaur, LAen_US
dc.contributor.authorWang, JJen_US
dc.contributor.authorTeber, Een_US
dc.contributor.authorLiew, Gen_US
dc.contributor.authorCheung, Nen_US
dc.contributor.authorWong, TYen_US
dc.contributor.authorMitchell, Pen_US
dc.date.accessioned2013-05-28T06:15:10Z-
dc.date.available2013-05-28T06:15:10Z-
dc.date.issued2010en_US
dc.identifier.citationMicrocirculation, 2010, v. 17 n. 8, p. 660-668en_US
dc.identifier.issn1073-9688en_US
dc.identifier.urihttp://hdl.handle.net/10722/183599-
dc.description.abstractObjective: In the current study, we aimed to examine the associations of low birth weight with retinal vascular caliber and vascular fractal dimension during early adolescence.Methods: A population-based study of 12-year-old schoolchildren (2353/3144 [75.3%]) recruited from a random cluster sample of 21 schools. Birth weight, birth length and head circumference were obtained via parent report of the child's birth record. Retinal images were taken and vessel diameter and fractal dimension were quantified using validated computer-based methods.Results: After adjusting for age, sex, ethnicity, body mass index, iris color, axial length, mean arterial blood pressure, prematurity and fellow retinal vascular caliber, children in the lowest quartiles of birth weight had 2.5 μm narrower mean retinal arteriolar caliber than those in the highest quartiles (p for trend = 0.001). Associations were observed between shorter birth length and smaller head circumference with narrower retinal arterioles. Smaller head circumference was associated with decreased fractal dimension (p for trend = 0.03).Conclusions: Children with lower birth weight were more likely to have narrower retinal arterioles, while those with smaller head circumference were more likely to have reduced complexity of their retinal microvasculature. These variations in microvascular structure in adolescence could reflect a susceptibility to cardiovascular disease during adulthood, resulting from a disadvantaged growth environment in utero. © 2010 John Wiley & Sons Ltd.en_US
dc.languageengen_US
dc.relation.ispartofMicrocirculationen_US
dc.subject.meshArterioles - Anatomy & Histology - Embryology - Growth & Developmenten_US
dc.subject.meshBirth Weight - Physiologyen_US
dc.subject.meshBody Heighten_US
dc.subject.meshCardiovascular Diseases - Etiologyen_US
dc.subject.meshChilden_US
dc.subject.meshFemaleen_US
dc.subject.meshFetal Developmenten_US
dc.subject.meshFractalsen_US
dc.subject.meshHumansen_US
dc.subject.meshInfant, Low Birth Weight - Physiologyen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshMaleen_US
dc.subject.meshModels, Cardiovascularen_US
dc.subject.meshNew South Walesen_US
dc.subject.meshPregnancyen_US
dc.subject.meshRetinal Artery - Anatomy & Histology - Embryology - Growth & Developmenten_US
dc.titleSmaller Birth Size is Associated With Narrower Retinal Arterioles in Early Adolescenceen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1549-8719.2010.00062.xen_US
dc.identifier.pmid21044220-
dc.identifier.scopuseid_2-s2.0-78149271741en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78149271741&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume17en_US
dc.identifier.issue8en_US
dc.identifier.spage660en_US
dc.identifier.epage668en_US
dc.identifier.isiWOS:000283987300008-
dc.identifier.scopusauthoridGopinath, B=15829811000en_US
dc.identifier.scopusauthoridBaur, LA=7005262888en_US
dc.identifier.scopusauthoridWang, JJ=35231432000en_US
dc.identifier.scopusauthoridTeber, E=6508372989en_US
dc.identifier.scopusauthoridLiew, G=12796147900en_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridWong, TY=35231271400en_US
dc.identifier.scopusauthoridMitchell, P=7402933815en_US

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