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Article: Alterations in retinal microvascular geometry in young type 1 diabetes

TitleAlterations in retinal microvascular geometry in young type 1 diabetes
Authors
Issue Date2010
PublisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/
Citation
Diabetes Care, 2010, v. 33 n. 6, p. 1331-1336 How to Cite?
AbstractOBJECTIVE - To describe retinal microvascular geometric parameters in young patients with type 1 diabetes. RESEARCH DESIGN AND METHODS - Patients with type 1 diabetes (aged 12-20 years) had clinical assessments and retinal photography following standardized protocol at a tertiary-care hospital in Sydney. Retinal microvascular geometry, including arteriolar and venular tortuosity, branching angles, optimality deviation, and length-to-diameter ratio (LDR), were measured from digitized photographs. Associations of these geometric characteristics with diabetes duration, A1C level, systolic blood pressure (SBP), and other risk factors were assessed. RESULTS - Of 1,159 patients enrolled, 944 (81.4%) had gradable photographs and 170 (14.7%) had retinopathy. Older age was associated with decreased arteriolar (P = 0.024) and venular (P = 0.002) tortuosity, and female subjects had larger arteriolar branching angle than male subjects (P = 0.03). After adjusting for age and sex, longer diabetes duration was associated with larger arteriolar branching angle (P ≤ 0.001) and increased arteriolar optimality deviation (P = 0.018), higher A1C was associated with increased arteriolar tortuosity (>8.5 vs. ≤8.5%, P = 0.008), higher SBP was associated with decreased arteriolar LDR (P = 0.002), and higher total cholesterol levels were associated with increased arteriolar LDR (P = 0.044) and decreased venular optimality deviation (P = 0.044). These associations remained after controlling for A1C, retinal vessel caliber, and retinopathy status and were seen in subjects without retinopathy. CONCLUSIONS - Key diabetes-related factors affect retinal microvascular geometry in young type 1 diabetes, even in those without evidence of retinopathy. These early retinal alterations may be markers of diabetes microvascular complications. © 2010 by the American Diabetes Association.
Persistent Identifierhttp://hdl.handle.net/10722/183591
ISSN
2015 Impact Factor: 8.934
2015 SCImago Journal Rankings: 5.827
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorSasongko, MBen_US
dc.contributor.authorWang, JJen_US
dc.contributor.authorDonaghue, KCen_US
dc.contributor.authorCheung, Nen_US
dc.contributor.authorBenitezAguirre, Pen_US
dc.contributor.authorJenkins, Aen_US
dc.contributor.authorHsu, Wen_US
dc.contributor.authorLee, MLen_US
dc.contributor.authorWong, TYen_US
dc.date.accessioned2013-05-28T06:15:05Z-
dc.date.available2013-05-28T06:15:05Z-
dc.date.issued2010en_US
dc.identifier.citationDiabetes Care, 2010, v. 33 n. 6, p. 1331-1336en_US
dc.identifier.issn0149-5992en_US
dc.identifier.urihttp://hdl.handle.net/10722/183591-
dc.description.abstractOBJECTIVE - To describe retinal microvascular geometric parameters in young patients with type 1 diabetes. RESEARCH DESIGN AND METHODS - Patients with type 1 diabetes (aged 12-20 years) had clinical assessments and retinal photography following standardized protocol at a tertiary-care hospital in Sydney. Retinal microvascular geometry, including arteriolar and venular tortuosity, branching angles, optimality deviation, and length-to-diameter ratio (LDR), were measured from digitized photographs. Associations of these geometric characteristics with diabetes duration, A1C level, systolic blood pressure (SBP), and other risk factors were assessed. RESULTS - Of 1,159 patients enrolled, 944 (81.4%) had gradable photographs and 170 (14.7%) had retinopathy. Older age was associated with decreased arteriolar (P = 0.024) and venular (P = 0.002) tortuosity, and female subjects had larger arteriolar branching angle than male subjects (P = 0.03). After adjusting for age and sex, longer diabetes duration was associated with larger arteriolar branching angle (P ≤ 0.001) and increased arteriolar optimality deviation (P = 0.018), higher A1C was associated with increased arteriolar tortuosity (>8.5 vs. ≤8.5%, P = 0.008), higher SBP was associated with decreased arteriolar LDR (P = 0.002), and higher total cholesterol levels were associated with increased arteriolar LDR (P = 0.044) and decreased venular optimality deviation (P = 0.044). These associations remained after controlling for A1C, retinal vessel caliber, and retinopathy status and were seen in subjects without retinopathy. CONCLUSIONS - Key diabetes-related factors affect retinal microvascular geometry in young type 1 diabetes, even in those without evidence of retinopathy. These early retinal alterations may be markers of diabetes microvascular complications. © 2010 by the American Diabetes Association.en_US
dc.languageengen_US
dc.publisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/en_US
dc.relation.ispartofDiabetes Careen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshChilden_US
dc.subject.meshDiabetes Mellitus, Type 1 - Complicationsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMicrovessels - Pathologyen_US
dc.subject.meshRetinal Diseases - Etiologyen_US
dc.subject.meshRetinal Vessels - Pathologyen_US
dc.subject.meshYoung Adulten_US
dc.titleAlterations in retinal microvascular geometry in young type 1 diabetesen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.2337/dc10-0055en_US
dc.identifier.pmid20299479-
dc.identifier.pmcidPMC2875449-
dc.identifier.scopuseid_2-s2.0-77953213687en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77953213687&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume33en_US
dc.identifier.issue6en_US
dc.identifier.spage1331en_US
dc.identifier.epage1336en_US
dc.identifier.isiWOS:000279304300036-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridSasongko, MB=36100847400en_US
dc.identifier.scopusauthoridWang, JJ=35231432000en_US
dc.identifier.scopusauthoridDonaghue, KC=7003470857en_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridBenitezAguirre, P=26535507200en_US
dc.identifier.scopusauthoridJenkins, A=7202458130en_US
dc.identifier.scopusauthoridHsu, W=7402002763en_US
dc.identifier.scopusauthoridLee, ML=7409117252en_US
dc.identifier.scopusauthoridWong, TY=7403531208en_US

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