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Article: Natural History of Branch Retinal Vein Occlusion: An Evidence-Based Systematic Review

TitleNatural History of Branch Retinal Vein Occlusion: An Evidence-Based Systematic Review
Authors
Issue Date2010
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ophtha
Citation
Ophthalmology, 2010, v. 117 n. 6, p. 1094-1101.e5 How to Cite?
AbstractObjective: To describe the natural history of branch retinal vein occlusion (BRVO) based on the best available evidence from the literature. Clinical Relevance: Branch retinal vein occlusion is the second most frequent major retinal vascular disease. Although several new treatments for BRVO are currently being introduced, data on its natural history are sparse. Methods: English language articles were retrieved using a keyword search of MEDLINE, EMBASE, Current Contents, and the Cochrane Library to November 13, 2008, supplemented by manually searching the references of review articles published within the last 5 years. All relevant observational studies evaluating the natural history of BRVO and all clinical trials evaluating BRVO interventions with an untreated control arm were independently identified by 2 investigators. Results: Of a total of 5965 citations retrieved, 24 eligible studies were identified and reviewed, providing 1608 eyes with BRVO with data on natural history. Visual acuity (VA) was moderately poor at baseline (<20/40). Although VA generally improved, with mean improvement ranging from 1 letter at 6 weeks to 28 letters up to 24 months, few studies reported improvement beyond 20/40. Over a 1-year period, 5% to 15% of eyes developed macular edema (ME), but of those with ME at baseline, 18% to 41% resolved. At baseline, 5% to 6% of eyes had bilateral BRVO, with 10% developing fellow eye involvement over time. There were few high-quality studies on other outcomes, including development of new vessels. Conclusions: Visual acuity generally improved in eyes with BRVO without intervention, although clinically significant improvement beyond 20/40 was uncommon. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references. © 2010 American Academy of Ophthalmology.
Persistent Identifierhttp://hdl.handle.net/10722/183589
ISSN
2015 Impact Factor: 6.75
2015 SCImago Journal Rankings: 4.745
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorRogers, SLen_US
dc.contributor.authorMcintosh, RLen_US
dc.contributor.authorLim, Len_US
dc.contributor.authorMitchell, Pen_US
dc.contributor.authorCheung, Nen_US
dc.contributor.authorKowalski, JWen_US
dc.contributor.authorNguyen, HPen_US
dc.contributor.authorWang, JJen_US
dc.contributor.authorWong, TYen_US
dc.date.accessioned2013-05-28T06:15:03Z-
dc.date.available2013-05-28T06:15:03Z-
dc.date.issued2010en_US
dc.identifier.citationOphthalmology, 2010, v. 117 n. 6, p. 1094-1101.e5en_US
dc.identifier.issn0161-6420en_US
dc.identifier.urihttp://hdl.handle.net/10722/183589-
dc.description.abstractObjective: To describe the natural history of branch retinal vein occlusion (BRVO) based on the best available evidence from the literature. Clinical Relevance: Branch retinal vein occlusion is the second most frequent major retinal vascular disease. Although several new treatments for BRVO are currently being introduced, data on its natural history are sparse. Methods: English language articles were retrieved using a keyword search of MEDLINE, EMBASE, Current Contents, and the Cochrane Library to November 13, 2008, supplemented by manually searching the references of review articles published within the last 5 years. All relevant observational studies evaluating the natural history of BRVO and all clinical trials evaluating BRVO interventions with an untreated control arm were independently identified by 2 investigators. Results: Of a total of 5965 citations retrieved, 24 eligible studies were identified and reviewed, providing 1608 eyes with BRVO with data on natural history. Visual acuity (VA) was moderately poor at baseline (<20/40). Although VA generally improved, with mean improvement ranging from 1 letter at 6 weeks to 28 letters up to 24 months, few studies reported improvement beyond 20/40. Over a 1-year period, 5% to 15% of eyes developed macular edema (ME), but of those with ME at baseline, 18% to 41% resolved. At baseline, 5% to 6% of eyes had bilateral BRVO, with 10% developing fellow eye involvement over time. There were few high-quality studies on other outcomes, including development of new vessels. Conclusions: Visual acuity generally improved in eyes with BRVO without intervention, although clinically significant improvement beyond 20/40 was uncommon. Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references. © 2010 American Academy of Ophthalmology.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/ophthaen_US
dc.relation.ispartofOphthalmologyen_US
dc.subject.meshHumansen_US
dc.subject.meshRetinal Vein - Physiopathologyen_US
dc.subject.meshRetinal Vein Occlusion - Physiopathologyen_US
dc.subject.meshVisual Acuity - Physiologyen_US
dc.titleNatural History of Branch Retinal Vein Occlusion: An Evidence-Based Systematic Reviewen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ophtha.2010.01.058en_US
dc.identifier.pmid20430447-
dc.identifier.scopuseid_2-s2.0-77952890267en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77952890267&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume117en_US
dc.identifier.issue6en_US
dc.identifier.spage1094en_US
dc.identifier.epage1101.e5en_US
dc.identifier.isiWOS:000278224400006-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridRogers, SL=12768398500en_US
dc.identifier.scopusauthoridMcIntosh, RL=55166106200en_US
dc.identifier.scopusauthoridLim, L=15053336200en_US
dc.identifier.scopusauthoridMitchell, P=7402933815en_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridKowalski, JW=8243072500en_US
dc.identifier.scopusauthoridNguyen, HP=35741469200en_US
dc.identifier.scopusauthoridWang, JJ=55664024800en_US
dc.identifier.scopusauthoridWong, TY=7403531208en_US

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