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Article: Retinopathy predicts coronary heart disease mortality

TitleRetinopathy predicts coronary heart disease mortality
Authors
Issue Date2009
PublisherBMJ Publishing Group. The Journal's web site is located at http://heart.bmjjournals.com/
Citation
Heart, 2009, v. 95 n. 5, p. 391-394 How to Cite?
AbstractBackground: Retinopathy lesions are fairly common findings in clinic settings and may predict risk of coronary heart disease (CHD). Objective: To examine whether retinopathy independently predicts a risk of CHD-related mortality in people with and without diabetes. Methods: In an Australian population-based cohort of people with (n = 199) and without (n = 2768) diabetes (Blue Mountains Eye Study, total n = 2967), the presence and severity of retinopathy was assessed from retinal photographs. 12-Year cumulative CHD deaths were ascertained from Australian National Death Index records. Results: Over 12 years, 353 participants (11.9%) had incident CHD-related deaths. Retinopathy was present in 57/199 (28.6%) participants with, and in 268/2768 (9.7%) without, diabetes. The presence of retinopathy increased the CHD mortality rate per person-year by an amount (0.005) equivalent to the presence of diabetes itself (12-year CHD mortality rate per person-year of 0.010 in people with neither diabetes nor retinopathy, 0.015 in those with diabetes alone, 0.016 in those with retinopathy alone). After adjusting for cardiovascular risk factors, retinopathy remained an independent predictor of CHD death both in people with diabetes (hazard ratio (HR) = 2.21, 95% CI 1.20 to 4.05) and in those without diabetes (HR = 1.33, 95% CI 1.02 to 1.83). Moderate retinopathy was associated with adjusted HR = 6.68 (95% CI 2.24 to 20.0) in people with diabetes and adjusted HR = 2.29 (95% CI 1.10 to 4.76) in people without diabetes. Conclusions: A finding of retinopathy in people with or without diabetes may signal increased CHD risk. The increased CHD mortality associated with retinopathy in people without diabetes was equivalent to the presence of diabetes itself.
Persistent Identifierhttp://hdl.handle.net/10722/183567
ISSN
2015 Impact Factor: 5.693
2015 SCImago Journal Rankings: 2.647
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLiew, Gen_US
dc.contributor.authorWong, TYen_US
dc.contributor.authorMitchell, Pen_US
dc.contributor.authorCheung, Nen_US
dc.contributor.authorWang, JJen_US
dc.date.accessioned2013-05-28T06:14:48Z-
dc.date.available2013-05-28T06:14:48Z-
dc.date.issued2009en_US
dc.identifier.citationHeart, 2009, v. 95 n. 5, p. 391-394en_US
dc.identifier.issn1355-6037en_US
dc.identifier.urihttp://hdl.handle.net/10722/183567-
dc.description.abstractBackground: Retinopathy lesions are fairly common findings in clinic settings and may predict risk of coronary heart disease (CHD). Objective: To examine whether retinopathy independently predicts a risk of CHD-related mortality in people with and without diabetes. Methods: In an Australian population-based cohort of people with (n = 199) and without (n = 2768) diabetes (Blue Mountains Eye Study, total n = 2967), the presence and severity of retinopathy was assessed from retinal photographs. 12-Year cumulative CHD deaths were ascertained from Australian National Death Index records. Results: Over 12 years, 353 participants (11.9%) had incident CHD-related deaths. Retinopathy was present in 57/199 (28.6%) participants with, and in 268/2768 (9.7%) without, diabetes. The presence of retinopathy increased the CHD mortality rate per person-year by an amount (0.005) equivalent to the presence of diabetes itself (12-year CHD mortality rate per person-year of 0.010 in people with neither diabetes nor retinopathy, 0.015 in those with diabetes alone, 0.016 in those with retinopathy alone). After adjusting for cardiovascular risk factors, retinopathy remained an independent predictor of CHD death both in people with diabetes (hazard ratio (HR) = 2.21, 95% CI 1.20 to 4.05) and in those without diabetes (HR = 1.33, 95% CI 1.02 to 1.83). Moderate retinopathy was associated with adjusted HR = 6.68 (95% CI 2.24 to 20.0) in people with diabetes and adjusted HR = 2.29 (95% CI 1.10 to 4.76) in people without diabetes. Conclusions: A finding of retinopathy in people with or without diabetes may signal increased CHD risk. The increased CHD mortality associated with retinopathy in people without diabetes was equivalent to the presence of diabetes itself.en_US
dc.languageengen_US
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://heart.bmjjournals.com/en_US
dc.relation.ispartofHearten_US
dc.subject.meshAustralia - Epidemiologyen_US
dc.subject.meshCoronary Disease - Mortalityen_US
dc.subject.meshDiabetic Retinopathy - Diagnosis - Mortalityen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluorescein Angiographyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMicrocirculationen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPredictive Value Of Testsen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshSeverity Of Illness Indexen_US
dc.titleRetinopathy predicts coronary heart disease mortalityen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1136/hrt.2008.146670en_US
dc.identifier.pmid18697802-
dc.identifier.scopuseid_2-s2.0-61949439048en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-61949439048&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume95en_US
dc.identifier.issue5en_US
dc.identifier.spage391en_US
dc.identifier.epage394en_US
dc.identifier.isiWOS:000263434000010-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridLiew, G=12796147900en_US
dc.identifier.scopusauthoridWong, TY=35231271400en_US
dc.identifier.scopusauthoridMitchell, P=7402933815en_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridWang, JJ=8853324200en_US

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