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Article: Corneal biomechanical properties and retinal vascular caliber in children

TitleCorneal biomechanical properties and retinal vascular caliber in children
Authors
Issue Date2009
PublisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.org
Citation
Investigative Ophthalmology And Visual Science, 2009, v. 50 n. 1, p. 121-125 How to Cite?
AbstractPURPOSE. To examine the relationship between corneal biomechanical properties and retinal vascular caliber in Singaporean children in a cross-sectional study of 257 healthy subjects from the Singapore Cohort Study of Risk Factors for Myopia. METHODS. Corneal hysteresis (CH), corneal resistance factor (CRF), central corneal thickness (CCT), and corneal compensated intraocular pressure (IOPCC) were measured with a patented dynamic bi-directional applanation device. Digital retinal photography was performed, and retinal vascular caliber was measured with custom software. The central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were calculated, representing the average arteriolar and venular calibers. Spherical equivalent (SE) refraction, axial length, height, weight, and mean arterial blood pressure (MABP) were measured. RESULTS. Mean values of this study were as follows: age of study subjects, 13.97 ± 0.90 years; CH, 11.80 ± 1.55 mm Hg; CRF, 11.83 ± 1.72 mm Hg; CCT, 578.76 ± 34.47 μm; IOPCC, 15.12 ± 2.84 mm Hg; CRAE, 151.70 ± 15.54 μm; CRVE, 227.51 ± 22.82 μm. After controlling for age, sex, ethnicity, body mass index, father's educational level, MABP, IOP, and SE, there was a significant increase in CRAE by 1.40 μm (95% CI: 0.17-2.61; P = 0.03) for every 1.55 mm Hg increase in CH and by 1.68 μm (95% CI: 0.21-3.15; P = 0.03) for every 1.72 mm Hg increase in CRF. There were no significant associations between CRVE and CH, CRF, CCT, or IOP. CONCLUSIONS. Lower CH and CRF are associated with narrower retinal arterioles in Singaporean children. Copyright © Association for Research in Vision and Ophthalmology.
Persistent Identifierhttp://hdl.handle.net/10722/183563
ISSN
2015 Impact Factor: 3.427
2015 SCImago Journal Rankings: 2.008
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLim, Len_US
dc.contributor.authorCheung, Nen_US
dc.contributor.authorGazzard, Gen_US
dc.contributor.authorChan, YHen_US
dc.contributor.authorWong, TYen_US
dc.contributor.authorSaw, SMen_US
dc.date.accessioned2013-05-28T06:14:46Z-
dc.date.available2013-05-28T06:14:46Z-
dc.date.issued2009en_US
dc.identifier.citationInvestigative Ophthalmology And Visual Science, 2009, v. 50 n. 1, p. 121-125en_US
dc.identifier.issn0146-0404en_US
dc.identifier.urihttp://hdl.handle.net/10722/183563-
dc.description.abstractPURPOSE. To examine the relationship between corneal biomechanical properties and retinal vascular caliber in Singaporean children in a cross-sectional study of 257 healthy subjects from the Singapore Cohort Study of Risk Factors for Myopia. METHODS. Corneal hysteresis (CH), corneal resistance factor (CRF), central corneal thickness (CCT), and corneal compensated intraocular pressure (IOPCC) were measured with a patented dynamic bi-directional applanation device. Digital retinal photography was performed, and retinal vascular caliber was measured with custom software. The central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were calculated, representing the average arteriolar and venular calibers. Spherical equivalent (SE) refraction, axial length, height, weight, and mean arterial blood pressure (MABP) were measured. RESULTS. Mean values of this study were as follows: age of study subjects, 13.97 ± 0.90 years; CH, 11.80 ± 1.55 mm Hg; CRF, 11.83 ± 1.72 mm Hg; CCT, 578.76 ± 34.47 μm; IOPCC, 15.12 ± 2.84 mm Hg; CRAE, 151.70 ± 15.54 μm; CRVE, 227.51 ± 22.82 μm. After controlling for age, sex, ethnicity, body mass index, father's educational level, MABP, IOP, and SE, there was a significant increase in CRAE by 1.40 μm (95% CI: 0.17-2.61; P = 0.03) for every 1.55 mm Hg increase in CH and by 1.68 μm (95% CI: 0.21-3.15; P = 0.03) for every 1.72 mm Hg increase in CRF. There were no significant associations between CRVE and CH, CRF, CCT, or IOP. CONCLUSIONS. Lower CH and CRF are associated with narrower retinal arterioles in Singaporean children. Copyright © Association for Research in Vision and Ophthalmology.en_US
dc.languageengen_US
dc.publisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.orgen_US
dc.relation.ispartofInvestigative Ophthalmology and Visual Scienceen_US
dc.subject.meshAdolescenten_US
dc.subject.meshArterioles - Anatomy & Histologyen_US
dc.subject.meshBiomechanicsen_US
dc.subject.meshBlood Pressure - Physiologyen_US
dc.subject.meshCornea - Physiologyen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshEthnic Groupsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIntraocular Pressure - Physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshPhotographyen_US
dc.subject.meshRetinal Vessels - Anatomy & Histologyen_US
dc.subject.meshSingaporeen_US
dc.subject.meshVenules - Anatomy & Histologyen_US
dc.titleCorneal biomechanical properties and retinal vascular caliber in childrenen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1167/iovs.08-2352en_US
dc.identifier.pmid18775868-
dc.identifier.scopuseid_2-s2.0-58249091538en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-58249091538&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume50en_US
dc.identifier.issue1en_US
dc.identifier.spage121en_US
dc.identifier.epage125en_US
dc.identifier.isiWOS:000262199900017-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLim, L=8721287400en_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridGazzard, G=7004147260en_US
dc.identifier.scopusauthoridChan, YH=7403675912en_US
dc.identifier.scopusauthoridWong, TY=7403531208en_US
dc.identifier.scopusauthoridSaw, SM=7006402006en_US

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