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Article: Retinal arteriolar dilation predicts retinopathy in adolescents with type 1 diabetes

TitleRetinal arteriolar dilation predicts retinopathy in adolescents with type 1 diabetes
Authors
Issue Date2008
PublisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/
Citation
Diabetes Care, 2008, v. 31 n. 9, p. 1842-1846 How to Cite?
AbstractOBJECTIVE - Alterations in retinal vascular caliber may reflect early subclinical microvascular dysfunction. In this study, we examined the association of retinal vascular caliber to incident retinopathy in young patients with type 1 diabetes. RESEARCH DESIGN AND METHODS - This was a prospective cohort study of 645 initially retinopathy-free type 1 diabetic patients, aged 12-20 years. Participants had seven-field stereoscopic retinal photographs taken of both eyes at baseline and follow-up. Retinal vascular caliber was measured from baseline photographs using a computer-based program following a standardized protocol. Incident retinopathy was graded according to the modified Airlie House classification from follow-up photographs. RESULTS - Over a median follow-up of 2.5 years, 274 participants developed retinopathy (14.8 per 100 person-years). After adjustments for age, sex, diabetes duration, glycemia, mean arterial blood pressure, BMI, and cholesterol levels, larger retinal arteriolar caliber (fourth versus first quartile) was associated with a more than threefold higher risk of retinopathy (hazard rate ratio 3.44 [95% CI 2.08-5.66]). Each SD increase in retinal arteriolar caliber was associated with a 46% increase in retinopathy risk (1.46 [1.22-1.74]). This association was stronger in female than in male participants. After similar adjustments, retinal venular caliber was not consistently associated with incident retinopathy. CONCLUSIONS - Retinal arteriolar dilatation predicts retinopathy development in young patients with type 1 diabetes. Our data suggest that arteriolar dysfunction may play a critical role in the pathogenesis of early diabetic retinopathy and that computer-based retinal vascular caliber measurements may provide additional prognostic information regarding risk of diabetes micro-vascular complications. © 2008 by the American Diabetes Association.
Persistent Identifierhttp://hdl.handle.net/10722/183561
ISSN
2015 Impact Factor: 8.934
2015 SCImago Journal Rankings: 5.827
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, Nen_US
dc.contributor.authorRogers, SLen_US
dc.contributor.authorDonaghue, KCen_US
dc.contributor.authorJenkins, AJen_US
dc.contributor.authorTikellis, Gen_US
dc.contributor.authorWong, TYen_US
dc.date.accessioned2013-05-28T06:14:45Z-
dc.date.available2013-05-28T06:14:45Z-
dc.date.issued2008en_US
dc.identifier.citationDiabetes Care, 2008, v. 31 n. 9, p. 1842-1846en_US
dc.identifier.issn0149-5992en_US
dc.identifier.urihttp://hdl.handle.net/10722/183561-
dc.description.abstractOBJECTIVE - Alterations in retinal vascular caliber may reflect early subclinical microvascular dysfunction. In this study, we examined the association of retinal vascular caliber to incident retinopathy in young patients with type 1 diabetes. RESEARCH DESIGN AND METHODS - This was a prospective cohort study of 645 initially retinopathy-free type 1 diabetic patients, aged 12-20 years. Participants had seven-field stereoscopic retinal photographs taken of both eyes at baseline and follow-up. Retinal vascular caliber was measured from baseline photographs using a computer-based program following a standardized protocol. Incident retinopathy was graded according to the modified Airlie House classification from follow-up photographs. RESULTS - Over a median follow-up of 2.5 years, 274 participants developed retinopathy (14.8 per 100 person-years). After adjustments for age, sex, diabetes duration, glycemia, mean arterial blood pressure, BMI, and cholesterol levels, larger retinal arteriolar caliber (fourth versus first quartile) was associated with a more than threefold higher risk of retinopathy (hazard rate ratio 3.44 [95% CI 2.08-5.66]). Each SD increase in retinal arteriolar caliber was associated with a 46% increase in retinopathy risk (1.46 [1.22-1.74]). This association was stronger in female than in male participants. After similar adjustments, retinal venular caliber was not consistently associated with incident retinopathy. CONCLUSIONS - Retinal arteriolar dilatation predicts retinopathy development in young patients with type 1 diabetes. Our data suggest that arteriolar dysfunction may play a critical role in the pathogenesis of early diabetic retinopathy and that computer-based retinal vascular caliber measurements may provide additional prognostic information regarding risk of diabetes micro-vascular complications. © 2008 by the American Diabetes Association.en_US
dc.languageengen_US
dc.publisherAmerican Diabetes Association. The Journal's web site is located at http://diabetes.diabetesjournals.org/en_US
dc.relation.ispartofDiabetes Careen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshArterioles - Physiopathologyen_US
dc.subject.meshChilden_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshDiabetes Mellitus, Type 1 - Complicationsen_US
dc.subject.meshDiabetic Retinopathy - Epidemiology - Physiopathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluorescein Angiographyen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRetinal Vessels - Physiopathologyen_US
dc.subject.meshRisk Factorsen_US
dc.titleRetinal arteriolar dilation predicts retinopathy in adolescents with type 1 diabetesen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.2337/dc08-0189en_US
dc.identifier.pmid18523143-
dc.identifier.pmcidPMC2518356-
dc.identifier.scopuseid_2-s2.0-56149120272en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-56149120272&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume31en_US
dc.identifier.issue9en_US
dc.identifier.spage1842en_US
dc.identifier.epage1846en_US
dc.identifier.isiWOS:000258868800026-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridRogers, SL=12768398500en_US
dc.identifier.scopusauthoridDonaghue, KC=7003470857en_US
dc.identifier.scopusauthoridJenkins, AJ=7202458130en_US
dc.identifier.scopusauthoridTikellis, G=6602765289en_US
dc.identifier.scopusauthoridWong, TY=7403531208en_US

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