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Article: Traditional and novel cardiovascular risk factors for retinal vein occlusion: The multiethnic study of atherosclerosis

TitleTraditional and novel cardiovascular risk factors for retinal vein occlusion: The multiethnic study of atherosclerosis
Authors
Issue Date2008
PublisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.org
Citation
Investigative Ophthalmology And Visual Science, 2008, v. 49 n. 10, p. 4297-4302 How to Cite?
AbstractPURPOSE. To describe the prevalence of retinal vein occlusion (RVO) and its association with cardiovascular, inflammatory, and hematologic risk factors in a multiethnic cohort. METHODS. This was a population-based, cross-sectional study of 6147 participants (whites, blacks, Hispanics, Chinese) from six U.S. communities. RVO was defined from retinal photographs taken from both eyes according to a standardized protocol. Risk factors were assessed from interviews, examinations, and laboratory and radiologic investigations. RESULTS. The prevalence of RVO was 1.1% (0.9% for branch RVO and 0.2% for central RVO) and was similar across different ethnic groups: 0.9% in whites, 1.2% in blacks, 1.2% in Hispanics, and 1.1% in Chinese (P = 0.76). Independent risk factors associated with RVO were hypertension (odds ratio [OR], 2.06; 95% confidence interval [CI], 1.18 -3.59), older age (OR, 1.34; 95% CI, 1.00-1.81, per decade increase), less education (OR, 4.08; 95% CI, 2.20-7.54), hypertriglyceridemia (OR, 1.98; 95% CI, 1.10-3.56), renal dysfunction (OR, 1.85; 95% CI, 1.01-3.39), and the presence of retinal arteriovenous nicking (OR, 4.01; 95% CI, 2.06-7.81) and focal arteriolar narrowing (OR, 4.38; 95% CI, 1.44-13.34). RVO was not significantly associated with direct measures of subclinical atherosclerosis (e.g., carotid intima media thickness and coronary artery calcium scores) or markers of inflammation (e.g., C reactive protein, interleukin-6) and endothelial dysfunction (e.g., soluble intercellular adhesion molecule-1) or coagulation (e.g., D-dimer). CONCLUSIONS. The prevalence of RVO is similar across different racial/ethnic groups. In the general population, RVO is associated with hypertension, dyslipidemia, and renal dysfunction, but not with atherosclerotic disease, systemic inflammation, and hematologic abnormalities. Copyright © Association for Research in Vision and Ophthalmology.
Persistent Identifierhttp://hdl.handle.net/10722/183556
ISSN
2015 Impact Factor: 3.427
2015 SCImago Journal Rankings: 2.008
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, Nen_US
dc.contributor.authorKlein, Ren_US
dc.contributor.authorJie, JWen_US
dc.contributor.authorCotch, MFen_US
dc.contributor.authorIslam, AFMen_US
dc.contributor.authorKlein, BEKen_US
dc.contributor.authorCushman, Men_US
dc.contributor.authorTien, YWen_US
dc.date.accessioned2013-05-28T06:14:41Z-
dc.date.available2013-05-28T06:14:41Z-
dc.date.issued2008en_US
dc.identifier.citationInvestigative Ophthalmology And Visual Science, 2008, v. 49 n. 10, p. 4297-4302en_US
dc.identifier.issn0146-0404en_US
dc.identifier.urihttp://hdl.handle.net/10722/183556-
dc.description.abstractPURPOSE. To describe the prevalence of retinal vein occlusion (RVO) and its association with cardiovascular, inflammatory, and hematologic risk factors in a multiethnic cohort. METHODS. This was a population-based, cross-sectional study of 6147 participants (whites, blacks, Hispanics, Chinese) from six U.S. communities. RVO was defined from retinal photographs taken from both eyes according to a standardized protocol. Risk factors were assessed from interviews, examinations, and laboratory and radiologic investigations. RESULTS. The prevalence of RVO was 1.1% (0.9% for branch RVO and 0.2% for central RVO) and was similar across different ethnic groups: 0.9% in whites, 1.2% in blacks, 1.2% in Hispanics, and 1.1% in Chinese (P = 0.76). Independent risk factors associated with RVO were hypertension (odds ratio [OR], 2.06; 95% confidence interval [CI], 1.18 -3.59), older age (OR, 1.34; 95% CI, 1.00-1.81, per decade increase), less education (OR, 4.08; 95% CI, 2.20-7.54), hypertriglyceridemia (OR, 1.98; 95% CI, 1.10-3.56), renal dysfunction (OR, 1.85; 95% CI, 1.01-3.39), and the presence of retinal arteriovenous nicking (OR, 4.01; 95% CI, 2.06-7.81) and focal arteriolar narrowing (OR, 4.38; 95% CI, 1.44-13.34). RVO was not significantly associated with direct measures of subclinical atherosclerosis (e.g., carotid intima media thickness and coronary artery calcium scores) or markers of inflammation (e.g., C reactive protein, interleukin-6) and endothelial dysfunction (e.g., soluble intercellular adhesion molecule-1) or coagulation (e.g., D-dimer). CONCLUSIONS. The prevalence of RVO is similar across different racial/ethnic groups. In the general population, RVO is associated with hypertension, dyslipidemia, and renal dysfunction, but not with atherosclerotic disease, systemic inflammation, and hematologic abnormalities. Copyright © Association for Research in Vision and Ophthalmology.en_US
dc.languageengen_US
dc.publisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.orgen_US
dc.relation.ispartofInvestigative Ophthalmology and Visual Scienceen_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAtherosclerosis - Ethnologyen_US
dc.subject.meshCardiovascular Diseases - Ethnologyen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshEthnic Groupsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension - Ethnologyen_US
dc.subject.meshHypertriglyceridemia - Ethnologyen_US
dc.subject.meshKidney Diseases - Ethnologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOdds Ratioen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshRetinal Vein Occlusion - Ethnologyen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshUnited States - Epidemiologyen_US
dc.titleTraditional and novel cardiovascular risk factors for retinal vein occlusion: The multiethnic study of atherosclerosisen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1167/iovs.08-1826en_US
dc.identifier.pmid18539932-
dc.identifier.pmcidPMC2584770-
dc.identifier.scopuseid_2-s2.0-53449090577en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-53449090577&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume49en_US
dc.identifier.issue10en_US
dc.identifier.spage4297en_US
dc.identifier.epage4302en_US
dc.identifier.isiWOS:000259703900012-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridKlein, R=35232138400en_US
dc.identifier.scopusauthoridJie, JW=7701312737en_US
dc.identifier.scopusauthoridCotch, MF=6603036992en_US
dc.identifier.scopusauthoridIslam, AFM=16033054600en_US
dc.identifier.scopusauthoridKlein, BEK=35433541400en_US
dc.identifier.scopusauthoridCushman, M=7103113524en_US
dc.identifier.scopusauthoridTien, YW=7006578954en_US

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