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Article: Diabetic Retinopathy and Risk of Heart Failure

TitleDiabetic Retinopathy and Risk of Heart Failure
Authors
Issue Date2008
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jac
Citation
Journal Of The American College Of Cardiology, 2008, v. 51 n. 16, p. 1573-1578 How to Cite?
AbstractObjectives: The purpose of this study was to examine the association of diabetic retinopathy with incident heart failure (HF). Background: Microvascular disease might play a more prominent role in the pathogenesis of diabetic cardiomyopathy, a major cause of HF in diabetes. Whether diabetic retinopathy, a microvascular complication of diabetes, predicts HF is unclear. Methods: A population-based study included 1,021 middle-aged type 2 diabetic persons with normal renal function and free of clinical coronary heart disease or HF at baseline. Diabetic retinopathy signs were graded from retinal photographs. Incident HF events were prospectively identified from hospital stay and death records. Results: There were 125 (12.8%) participants with diabetic retinopathy. After 9-year follow-up, 106 (10.1%) participants developed incident HF events. Persons with retinopathy were more likely to develop HF (cumulative incidence of 21.6%) than those without retinopathy (cumulative incidence of 8.5%). After controlling for age, gender, race, smoking, diabetes duration, insulin use, blood pressure, lipid profile, and other risk factors, participants with retinopathy had more than 2.5-fold higher risk of developing HF than those without retinopathy (hazard ratio [HR] 2.71; 95% confidence interval [CI] 1.46 to 5.05). This association remained significant after further adjustments for glycemic control, carotid atherosclerosis, and serum markers of endothelial dysfunction (HR 2.20, 95% CI 1.08 to 4.47). Conclusions: The presence of diabetic retinopathy signifies an excess risk of HF, independent of known risk factors. This further supports a contribution of microvascular disease to the development of HF in people with diabetes. © 2008 American College of Cardiology Foundation.
Persistent Identifierhttp://hdl.handle.net/10722/183541
ISSN
2015 Impact Factor: 17.759
2015 SCImago Journal Rankings: 10.097
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, Nen_US
dc.contributor.authorWang, JJen_US
dc.contributor.authorRogers, SLen_US
dc.contributor.authorBrancati, Fen_US
dc.contributor.authorKlein, Ren_US
dc.contributor.authorSharrett, ARen_US
dc.contributor.authorWong, TYen_US
dc.date.accessioned2013-05-28T06:14:33Z-
dc.date.available2013-05-28T06:14:33Z-
dc.date.issued2008en_US
dc.identifier.citationJournal Of The American College Of Cardiology, 2008, v. 51 n. 16, p. 1573-1578en_US
dc.identifier.issn0735-1097en_US
dc.identifier.urihttp://hdl.handle.net/10722/183541-
dc.description.abstractObjectives: The purpose of this study was to examine the association of diabetic retinopathy with incident heart failure (HF). Background: Microvascular disease might play a more prominent role in the pathogenesis of diabetic cardiomyopathy, a major cause of HF in diabetes. Whether diabetic retinopathy, a microvascular complication of diabetes, predicts HF is unclear. Methods: A population-based study included 1,021 middle-aged type 2 diabetic persons with normal renal function and free of clinical coronary heart disease or HF at baseline. Diabetic retinopathy signs were graded from retinal photographs. Incident HF events were prospectively identified from hospital stay and death records. Results: There were 125 (12.8%) participants with diabetic retinopathy. After 9-year follow-up, 106 (10.1%) participants developed incident HF events. Persons with retinopathy were more likely to develop HF (cumulative incidence of 21.6%) than those without retinopathy (cumulative incidence of 8.5%). After controlling for age, gender, race, smoking, diabetes duration, insulin use, blood pressure, lipid profile, and other risk factors, participants with retinopathy had more than 2.5-fold higher risk of developing HF than those without retinopathy (hazard ratio [HR] 2.71; 95% confidence interval [CI] 1.46 to 5.05). This association remained significant after further adjustments for glycemic control, carotid atherosclerosis, and serum markers of endothelial dysfunction (HR 2.20, 95% CI 1.08 to 4.47). Conclusions: The presence of diabetic retinopathy signifies an excess risk of HF, independent of known risk factors. This further supports a contribution of microvascular disease to the development of HF in people with diabetes. © 2008 American College of Cardiology Foundation.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jacen_US
dc.relation.ispartofJournal of the American College of Cardiologyen_US
dc.subject.meshCardiomyopathies - Complicationsen_US
dc.subject.meshConfidence Intervalsen_US
dc.subject.meshDiabetes Mellitus, Type 2 - Blood - Complications - Physiopathologyen_US
dc.subject.meshDiabetic Retinopathy - Complicationsen_US
dc.subject.meshEndothelium - Physiopathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHealth Statusen_US
dc.subject.meshHealth Status Indicatorsen_US
dc.subject.meshHeart Failure - Etiology - Physiopathologyen_US
dc.subject.meshHemoglobin A, Glycosylated - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRisk Assessmenten_US
dc.subject.meshRisk Factorsen_US
dc.titleDiabetic Retinopathy and Risk of Heart Failureen_US
dc.typeArticleen_US
dc.identifier.emailCheung, N: dannycheung@hotmail.comen_US
dc.identifier.authorityCheung, N=rp01752en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.jacc.2007.11.076en_US
dc.identifier.pmid18420100-
dc.identifier.scopuseid_2-s2.0-41949083725en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-41949083725&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume51en_US
dc.identifier.issue16en_US
dc.identifier.spage1573en_US
dc.identifier.epage1578en_US
dc.identifier.isiWOS:000255353200007-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridCheung, N=8054683900en_US
dc.identifier.scopusauthoridWang, JJ=55664024800en_US
dc.identifier.scopusauthoridRogers, SL=12768398500en_US
dc.identifier.scopusauthoridBrancati, F=35378166300en_US
dc.identifier.scopusauthoridKlein, R=35232138400en_US
dc.identifier.scopusauthoridSharrett, AR=7006662570en_US
dc.identifier.scopusauthoridWong, TY=7403531208en_US

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